DAC NO.: HDAC004220
DAC name: CRC_LM_TLS
Contact person: Kuang Ming
URL: http://www.fahsysu.org.cn/node/650
Description: We provide a comprehensive comparative analysis of the immune ecosystems of CRLM with or without TLSs by spatial enhanced resolution omics-sequencing (Stereo-seq) (from 10 patients) and single cell RNA-sequencing (scRNA-seq) (from 14 patients). We disclose an important link between IgG+ PCs and TLSs, underlining the crucial role of IgG responses in anti-tumor immunity. We also find that fibroblast-derived CCL19 regulate B cell recruitment and TLSs formation, which can be a promising target to promote TLSs neogenesis and suppress CRLM growth.
