DAC NO.: HDAC004297
DAC name: CDK4/6 and CDK7 in TNBC
Contact person: Guo Xiaomao
URL: https://jamanetwork.com/journals/jamaoncology/article-abstract/2813582?resultClick=1
Description: We present a novel approach to overcoming the intrinsic resistance of TNBC to CDK4/6 inhibitors by targeting transcription regulator CDK7. This dual inhibition strategy induces a synthetic lethality effect in various TNBC models, both in vitro and in vivo, marking a pioneering therapeutic avenue for TNBC.
