DAC NO.: HDAC006403
DAC name: advanced HPSCC
Contact person: Li Guo
URL: https://health.baidu.com/doctordec/jianjie/da1e094d43cc4b7319f4
Description: Hypopharyngeal squamous cell carcinoma (HPSCC), an aggressive head and neck cancer with dismal prognosis, faces persistent chemoresistance to standard TPF (docetaxel, cisplatin, 5-fluorouracil) regimen. However, the immunological mechanisms underlying chemoresistance remain undefined. Here, we performed longitudinal single-cell RNA sequencing (scRNA-seq) profiling of paired pre-/post-TPF HPSCC specimens, mapping immune cell dynamics underlying chemoresistance.
