HERV

Disease Name	Lung Adenocarcinoma
Categories	Cancer
Description	A carcinoma originating in the lung and the most common lung cancer type in never-smokers malignant cells exhibit distinct features such as glandular epithelial, or tubular morphology mutations in KRAS, EGFR, BRAF, and ERBB2 genes are associated with this cancer.
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Publication	Reported Disease	Mapped Disease	Category	Sample Source	#Association	Method	Population
HervD_0010	Lung Adenocarcinoma	Lung Adenocarcinoma	Cancer	Tumor tissues,Lung tissues	8	RNA-seq	-
HervD_0031	Lung Adenocarcinoma	Lung Adenocarcinoma	Cancer	Primary tumor tissues	1538	RNA-seq	-
HervD_0082	Lung Adenocarcinoma	Lung Adenocarcinoma	Cancer	LUAD tissues,Lung adenocarcinoma cell line A549	4166	RNA-seq,CRISPR-Cas9	-
HervD_0103	Lung Adenocarcinoma	Lung Adenocarcinoma	Cancer	Tumor tissue	3	RNA-seq	-

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Reported Disease	Mapped Disease	Disease Category	HERV Element	Association at Omics Level	Variation	Log2FC	P value	P adj	Effected Gene	Gene Expression	Phenotype Change	Method	Sample Source
Lung Adenocarcinoma	Lung Adenocarcinoma	Cancer	THE1D-int	RNA Expression	Down	-	-	-	ZNF75D	Down	-	CRISPR-Cas9	Lung adenocarcinoma cell line A549
Lung Adenocarcinoma	Lung Adenocarcinoma	Cancer	LTR5_Hs	RNA Expression	Down	-	-	-	ZNF75D	Down	-	CRISPR-Cas9	Lung adenocarcinoma cell line A549
Lung Adenocarcinoma	Lung Adenocarcinoma	Cancer	LTR2752	RNA Expression	Up	-	-	<0.05	-	-	-	RNA-seq	Tumor tissue
Lung Adenocarcinoma	Lung Adenocarcinoma	Cancer	MER57F	RNA Expression	Up	-	-	<0.05	-	-	-	RNA-seq	Tumor tissue
Lung Adenocarcinoma	Lung Adenocarcinoma	Cancer	MER61B	RNA Expression	Up	-	-	<0.05	-	-	-	RNA-seq	Tumor tissue

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Reported Disease	Mapped Disease	Disease Category	HERV Name	Association at Omics Level	Variation	Log2FC	P value	P adj	Related Gene	Method	Sample Source	Population	Data Link

Gene Name	Ensembl ID	Gene Regulation	HERV Name	HERV Regulation	Correlation	P value	P adj