HERV

HERV Name	11q23.3_HML2
HERV Type	ERV2
Group	HML2
Alias	K(C11b), K37,ERVK-20
Position	chr11:118721015-118730174
Length	9160
Strand	-

Virus Source	Alpha-,Beta- and Delta-viruses
Earliest Shared Ancestor	Gorilla,13.35-24.18 mya
Structure variant
Region	Overlap
Nearby Genes	ENSG00000287238
Description	Human MMTV-like (HML) supergroup of class II
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HERV Name	Reproted Disease	Mapped Disease	Disease Category	Association at Omics Level	Variation	Log2FC	P value	P adj	Related Gene	Method	Sample Source	Population	Data Link	PMID
11q23.3_HML2	Head and Neck Cancer	Head and Neck Cancer	Cancer	RNA Expression	Up	1.8	1.99E-02	5.45E-02	-	RNA-seq	Tumor tissues	-	-	32872377
11q23.3_HML2	Breast Cancer	Breast Cancer	Cancer	RNA Expression	Up	3.17	<0.05	-	-	RNA-seq	MDAMB231 Breast cancer cells	-	GEO:GSE96860	35265522
11q23.3_HML2	Breast Cancer	Breast Cancer	Cancer	RNA Expression	Up	5.06	<0.05	-	-	RNA-seq	AU565 Breast cancer cells	-	GEO:GSE96860	35265522
11q23.3_HML2	Lung Adenocarcinoma	Lung Adenocarcinoma	Cancer	RNA Expression	Down	-1.77	1.40E-07	1.16E-06	ERBB2,BRAF,ROS1,CD274,MET,PDCD1	RNA-seq	Primary tumor tissues	-	-	36139593
11q23.3_HML2	Lung Squamous Cell Carcinoma	Lung Squamous Cell Carcinoma	Cancer	RNA Expression	Down	-2.79	2.16E-14	3.69E-13	ROS1,ERBB2,ALK,PDCD1,NRG1,CD274	RNA-seq	Primary tumor tissues	-	-	36139593

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Gene Name	Ensembl ID	Gene Regulation	HERV Name	HERV Regulation	Correlation	P value	P adj