ATB
ATB, is a novel cancer-related long noncoding RNA
Contents
Annotated Information
Approved Symbol
ATB
Approved Name
ATB: lncRNA-activated by TGF-β (lncRNA-ATB). [1] lncRNA-AL589182.3 [1] ENST00000493038 [1]
Characteristics
ATB is a 2 exon transcripts which strechtes over 80kb located on chromosome 14 [1] ATB is physically associated with the miR-200 family [1] [2] ATB is poly (A)-negative and mainly located in the cytoplasm [1]
Function
ATB mediates mechanisms involved in cancer progression [1] [2] [3] [4] ATB is found to be physically associated with the miR-200 family and may function as a ceRNA [2] ATB specially increases the stability of IL-11 mRNA, which depends on the binding of IL-11 mRNA [1] ATB Interacts with IL-11 mRNA and Activates IL-11/STAT3 Signaling in HCC Cells [1]
Regulation
ATB is regulated by Transforming growth factor β (TGF-β) [1]
Diseases
- Breast cancer [3]
- Colorectal cancer [3]
- Gastric cancer [3]
- Glioma [3]
- Hepatocellular carcinoma [3]
- Keloid [3]
- Lung cancer [3]
- Pancreatic cancer [3]
- Prostate cancer [3]
- Renal cell carcinoma [3]
Expression
ATB is a promising candidate among all tumour-associated lncRNAs and is overexpressed in numerous human cancers but downregulated in pancreatic cancer. Evidence regarding the abnormal expression, molecular mechanism and clinical significance of lncRNA-ATB shows that ATB is one of the most important regulatory RNAs in human cancer the lncRNA-ATB/miR-200s/ZEB axis playedan important role in TGF-β-induced EMT to promote invasion and metastasis [1][3]
Labs working on this lncRNA
- Department of Administration and Department of Aristogenesis, No. 202 Hospital of PLA, No. 5, Shenyang, 110003, Liaoning Province, P.R. China
- Department of Medical Genetics, Second Military Medical University, Shanghai, 200433, China
- Department of Hepatopancreatobiliary Surgery, Second Affiliated Hospital of Harbin Medical University, Harbin, China
References
- ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 Yuan J-h, Yang F, Wang F, Ma J-z, Guo Y-j, Tao Q-f et al. A long noncoding RNA activated by TGF-β promotes the invasion-metastasis cascade in hepatocellular carcinoma[J]. Cancer cell. 2014, 25(5):666-681.
- ↑ 2.0 2.1 2.2 Burk U, Schubert J, Wellner U, Schmalhofer O, Vincan E, Spaderna S et al. A reciprocal repression between ZEB1 and members of the miR‐200 family promotes EMT and invasion in cancer cells[J]. EMBO reports. 2008, 9(6):582-589.
- ↑ 3.00 3.01 3.02 3.03 3.04 3.05 3.06 3.07 3.08 3.09 3.10 3.11 Li J, Li Z, Zheng W, Li X, Wang Z, Cui Y et al. Lnc RNA‐ATB: An indispensable cancer‐related long noncoding RNA[J]. Cell proliferation. 2017, 50(6):e12381.
- ↑ Xiao H, Zhang F, Zou Y, Li J, Liu Y & Huang W. The Function and Mechanism of Long Non-coding RNA-ATB in Cancers[J]. Frontiers in physiology. 2018
