BCAN-AS1

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BCAN-AS1 functions as a tumor suppressor in cervical carcinoma via targeting miR-769-3p/PPWD1, providing a potential promising therapeutic target for cervical carcinoma.

Annotated Information

Name

Approved symbol:BCAN-AS1

Approved name:BCAN antisense RNA 1

HGNC ID:HGNC:55233

Alias symbol:RP11-284F21.9

RefSeq ID:XR_922175

Characteristics

Function

BCAN-AS1 directly interacted with miR-769-3p and functioned as the miR-769-3p sponge. xenograft tumor model re- vealed that overexpression of BCAN-AS1 inhibited tumor growth of cervical carcinoma invivo.[1].

Expression

BCAN-AS1 was down-regulated in cervical carcinoma tissues and cell lines. Overex- pression of RP11-284F21.9 inhibits proliferation, invasion and migration of cervical car- cinoma cells in vitro[1].

Regulation

BCAN-AS1 that was down-regulated in cervical carcinoma tissue and cell line.[1].

Diseases

  • Cervical carcinoma[1]

Labs working on this lncRNA

  • Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China[1].
  • Department of Dermatology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China[1].

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Han HF, Chen Q, Zhao WW. Long non-coding RNA RP11-284F21.9 functions as a ceRNA regulating PPWD1 by competitively binding to miR-769-3p in cervical carcinoma. Biosci Rep. 2020 Sep 30;40(9):BSR20200784. doi: 10.1042/BSR20200784.
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