CDK6-AS1

CDK6-AS1 plays a functional role in the pathogenesis and/or clinical responsiveness of B-ALL.<ref name="ref1">

Annotated Information

Name

Approved symbol:CDK6-AS1

Approved name:CDK6 antisense RNA 1

HGNC ID:40141

Alias symbols:BALR-2

RefSeq ID:NR_110086

Function

CDK6-AS1 can regulate cell survival and BALR-2 knockdown led to reduced proliferation, increased apoptosis, and increased sensitivity to prednisolone treatment.<ref name="ref1">.

Regulation

CDK6-AS1 can regulate cell survival.<ref name="ref1">

Expression

overexpression of CDK6-AS1 led to increased cell growth and resistance to prednisone treatment. <ref name="ref1">.

Disease

• B-acute lymphoblastic leukemia (B-ALL)<ref name="ref1">.

Labs working on this lncRNA

• Department of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, California<ref name="ref1">.

• Department of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, California. Cellular and Molecular Pathology Ph.D. Program, University of California, Los Angeles, Los Angeles, California<ref name="ref1">.

• Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, California<ref name="ref1">.

• Women and Child Health Department-Hematology-Oncology Laboratory, University of Padova, Padova, Italy<ref name="ref1">.

• Department of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, California. Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, California. Broad Stem Cell Research Center, University of California, Los Angeles, Los Angeles, California. drao@mednet.ucla.edu<ref name="ref1">.