COMETT
COMET (Correlated-to-MET), a natural antisense transcript that was highly expressed in carcinomas harboring BRAF V600E mutation or RET gene rearrangements and induced the downstream MAPK pathway.
Contents
Annotated Information
Name
Approved symbol:COMETT
Approved name:cytosolic oncogenic antisense to MET transcript
HGNC ID:51196
Previous name:long intergenic non-protein coding RNA 1510
Alias symbol:COMET
RefSeq ID:NR_120506
prev_symbol:LINC01510
Function
The oncogenic role of lncRNA COMET in thyroid and indicate it as a potential new target to overcome vemurafenib resistance in BRAF-mutated and MET-addicted carcinomas[1].
Regulation
Long noncoding RNA COMETT promotes the growth of colorectal cancer cells by modulating MET expression[1].
Expression
COMETT was significantly upregulated in CRC tissues and cell lines[1].
The COMETT expression level were associated with the clinicopathological grade and stage. Meanwhile, gain- and loss-of-function assays demonstrated that COMETT overexpression increased CRC cell proliferation, and promoted cell cycle progression from the G1 phase to the S phase[1].
In papillary thyroid carcinomas, COMET was part of a coexpression network including different oncogenes belonging to the MAPK pathway, and its expression highly correlated with MET expression[2].
Disease
- colorectal cancer[1].
- Papillary Thyroid Carcinomas[2].
Labs working on this lncRNA
- Department of Gastrointestinal Surgery, The Third Xiangya Hospital of Central South University, Tongzipo Road, Changsha, 410013 Hunan People's Republic of China[1].
- Department of Emergency Medicine and Intensive Care Unit, The Third Xiangya Hospital of Central South University, Tongzipo Road, Changsha, 410013 Hunan People's Republic of China[1].
- Department of Nuclear Medicine, The Third Xiangya Hospital of Central South University, Tongzipo Road, Changsha, 410013 Hunan People's Republic of China[1].
- Institute of Genetics and Biophysics "Adriano Buzzati-Traverso," CNR, Naples, Italy[2].
- Institute of Experimental Endocrinology and Oncology (IEOS), CNR, Naples, Italy[2].
- Department of Molecular Medicine and Medical Biotechnology, University of Naples "Federico II," Naples, Italy[2].
- Department of Science and Technology, University of Naples "Parthenope," Naples, Italy[2].
- Institute of Genetics and Biophysics "Adriano Buzzati-Traverso," CNR, Naples, Italy. valerio.costa@igb.cnr.it[2].
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Cen C, Li J, Liu J, Yang M, Zhang T, Zuo Y, Lin C, Li X. Long noncoding RNA LINC01510 promotes the growth of colorectal cancer cells by modulating MET expression. Cancer Cell Int. 2018 Mar 21;18:45. doi: 10.1186/s12935-018-0503-5.
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 Esposito R, Esposito D, Pallante P, Fusco A, Ciccodicola A, Costa V. Oncogenic Properties of the Antisense lncRNA COMET in BRAF- and RET-Driven Papillary Thyroid Carcinomas. Cancer Res. 2019 May 1;79(9):2124-2135. doi: 10.1158/0008-5472.CAN-18-2520. Epub 2019 Mar 12.
