DARS1-AS1
DARS-AS1, in myeloma is directly upregulated by hypoxia inducible factor (HIF)-1，play an important role in inhibiting apoptotic cell death in renal tubular cells.
Contents
Annotated Information
Name
Approved symbol:DARS1-AS1
Approved name:DARS1 antisense RNA 1
HGNC ID:40170
Previous name:DARS antisense RNA 1
RefSeq ID:NR_110199
prev_symbol:DARS-AS1
Characteristics
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Function
DARS-AS1 is required for the survival and tumorigenesis of myeloma cells both in vitro and in vivo DARS-AS1 exerts its function by binding RNA-binding motif protein 39 (RBM39), which impedes the interaction between RBM39 and its E3 ubiquitin ligase RNF147, and prevents RBM39 from degradation[1].
DARS-AS1 plays an important role in inhibiting apoptotic cell death in renal tubular cells[2].
Expression
The expression of novel lncRNA, DARS-AS1 (aspartyl-tRNA synthetase anti-sense 1), is up-regulated only under hypoxia and HIF-1 binds to its promoter region, which includes two hypoxia-responsive elements. Its expression is also up-regulated with cobalt chloride exposure, while it is not under hypoxia when HIF-1 is knocked down by siRNA[2].
Regulation
Long non-coding RNA DARS-AS1 in myeloma is directly upregulated by hypoxia inducible factor (HIF)-1[1].
Diseases
- apoptotic cell death in renal tubular cells[2]
- myeloma [1]
Labs working on this lncRNA
- DepartmDivision of Nephrology and Endocrinology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.[2]
- Isotope Science Center, The University of Tokyo., Tokyo, Japan.[2]
- Division of GenomeScience, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan.[2]
- Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan.[2]
- Division of Nephrology and Endocrinology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan mnangaku-tky@umin.ac.jp.[2]
- Department of Hematology, Affiliated Ruijin Hospital of Shanghai Jiao Tong University School of Medicine, Shanghai, China[1].
- Hongqiao International Institute of Medicine, Shanghai Tongren Hospital, Key Laboratory of Cell Differentiation and Apoptosis of the Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, China[1].
- Division of Hematology, Oncology, and Blood and Marrow Transplantation, Department of Internal Medicine, University of Iowa, Iowa City, IA, USA[1].
- Hongqiao International Institute of Medicine, Shanghai Tongren Hospital, Key Laboratory of Cell Differentiation and Apoptosis of the Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, China wuyingli@shsmu.edu.cn[1].
- Department of Hematology, Affiliated Ruijin Hospital of Shanghai Jiao Tong University School of Medicine, Shanghai, China yanhua_candy@163.com[1].
- Department of General Practice, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China[1].
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 Tong J, Xu X, Zhang Z, Ma C, Xiang R, Liu J, Xu W, Wu C, Li J, Zhan F, Wu Y, Yan H. Hypoxia-induced long non-coding RNA DARS-AS1 regulates RBM39 stability to promote myeloma malignancy. Haematologica. 2020 Jun;105(6):1630-1640. doi: 10.3324/haematol.2019.218289. Epub 2019 Jul 9.
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 Mimura I, Hirakawa Y, Kanki Y, Kushida N, Nakaki R, Suzuki Y, Tanaka T, Aburatani H, Nangaku M. Novel lnc RNA regulated by HIF-1 inhibits apoptotic cell death in the renal tubular epithelial cells under hypoxia. Physiol Rep. 2017 Apr;5(8):e13203.
