DELEC1
The DEC1 gene is a candidate tumor suppressor in 9q3
Contents
Annotated Information
Name
Approved symbol:DELEC1
Approved name:deleted in esophageal cancer 1
HGNC ID:23658
Alias symbol:CTS9
RefSeq ID:NR_163556
prev_symbol:1-Dec
Characteristics
DEC1 (deleted in esophageal cancer 1), from the commonly deleted region in a panel of esophageal squamous cell carcinomas to a approximately 200 kb genomic segment at 9q32[1][2].
Function
The DEC1 cDNA can suppress growth of some cancer cells in vitro[1].
Expression
Mutational analysis of this gene by reverse-transcriptase polymerase chain reaction disclosed significantly reduced expression of DEC1 in 8 of 13 (62%) esophageal cancer cell lines and in 16 of 30 (53%) primary squamous cell carcinomas of the esophagus.[1].
Regulation
Long non-coding RNA DARS-AS1 in myeloma is directly upregulated by hypoxia inducible factor (HIF)-1[1].
Diseases
- esophageal carcinomas [1]
Labs working on this lncRNA
- Laboratory of Molecular Medicine, The Institute of Medical Science, The University of Tokyo, Japan.[2]
- Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan.[1].
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Nishiwaki T, Daigo Y, Kawasoe T, Nakamura Y. Isolation and mutational analysis of a novel human cDNA, DEC1 (deleted in esophageal cancer 1), derived from the tumor suppressor locus in 9q32. Genes Chromosomes Cancer. 2000 Feb;27(2):169-76.
- ↑ 2.0 2.1 Miura K, Suzuki K, Tokino T, Isomura M, Inazawa J, Matsuno S, Nakamura Y. Detailed deletion mapping in squamous cell carcinomas of the esophagus narrows a region containing a putative tumor suppressor gene to about 200 kilobases on distal chromosome 9q. Cancer Res. 1996 Apr 1;56(7):1629-34.
