FAM99B
FAM99B may serve as a tumor suppressor in HCC and may provide a promising therapy target for patients with HCC.
Contents
Annotated Information
Name
Approved symbol：FAM99B
Approved name：family with sequence similarity 99 member B
HGNC ID：32369
Previous name：family with sequence similarity 99, member B|family with sequence similarity 99, member B (non-protein coding)|family with sequence similarity 99 member B (non-protein coding)
Alias symbol：DKFZp781M09150
RefSeq IDNR_：026642
LncBook ID：[1]
pubmed_id 31243545
Characteristics
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Function
FAM99B may serve as a tumor suppressor in HCC and may provide a promising therapy target for patients with HCC. [1].
EMS cooperates with the RNA binding protein RALY to stabilize E2F1 mRNA, and thereby increases E2F1 expression[1].
Regulation
Downregulated FAM99B was significantly associated with vascular invasion, advanced histologic grade, and T stage. [1].
Expression
Decreased FAM99B levels were significantly associated with poor overall survival in patients with HCC. Moreover, overexpression of FAM99B significantly inhibited cell proliferation, migration, and invasion in vitro. [1].
Diseases
- Preeclampsia (PE)[1].
Labs working on this lncRNA
- Department of Epidemiology, School of Public Health, Guangxi Medical University, Nanning, 530021, Guangxi, People's Republic of China.[1]
- Department of Epidemiology and Statistics, School of Public Health, Guilin Medical University, Guilin, 541004, Guangxi, People's Republic of China.[1]
- Department of Sanitary Chemistry, School of Public Health, Guangxi Medical University, Nanning, 530021, Guangxi, People's Republic of China.[1]
- Department of Epidemiology, School of Public Health, Guangxi Medical University, Nanning, 530021, Guangxi, People's Republic of China. xqqiu9999@sina.com.[1]
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 Mo M, Liu S, Ma X, Tan C, Wei L, Sheng Y, Song Y, Zeng X, Huang D, Qiu X. A liver-specific lncRNA, FAM99B, suppresses hepatocellular carcinoma progression through inhibition of cell proliferation, migration, and invasion. J Cancer Res Clin Oncol. 2019 Aug;145(8):2027-2038. doi: 10.1007/s00432-019-02954-8. Epub 2019 Jun 26. PMID: 31243545.
