GNG12-AS1

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Annotated Information

Approved Symbol

GNG12-AS1:GNG12 antisense RNA 1

Characteristics

GNG12-AS1 is an RNAPII Transcript with H3K36me3 Signatures of Transcribed Gene.[1]

Regulation

Neoplastic silencing of the normally active DIRAS3 allele reduces transcription of the GNG12-AS1 lncRNA in cis but does not affect its transcription on the homologous chromosome with the constitutively silent imprinted DIRAS3 allele. In addition, demethylation of a cancer cell line with loss of DIRAS3 Imprinting Leads to upregulation of DIRAS3 Expression and a Decrease in the Levels of GNG12-AS1 Transcripts.[1]

Expression

DIRAS3 and GNG12-AS1 Are Coexpressed in Several Tissues and Reduced in Breast Cancer [1].

DIRAS3 and GNG12-AS1 are coexpressed in several tissues and reduced in breast cancer. GNG12-AS1 has several splice variants, some splice variants of GNG12-AS1 are allele specific, all of which initiate from a single transcription start site. In placenta tissue and normal cell lines, GNG12-AS1 is biallelically expressed but some isoforms are allele-specifically spliced.[1]

Sequence

>gi|338827688|ref|NR_040077.1| Homo sapiens GNG12 antisense RNA 1 (GNG12-AS1), long non-coding RNA

000001 TTTCCTTCTC GACCCACTTG TTTGTATACA ACCACGCCCG GCAGGATGAC CACCAGATGA CCGGCCGCAG CAATGCCTCC 000080
000081 ACTCAGTCCC AGTTGGGCAA AGTTTCACTC CACTGCGGCG ACGTGAACAA GAATCACGGC TTCCTTATCG TACCTGCCAC 000160
000161 AACACATGGG AATTATGGGA GTACAATTTA AGATGAGATA TGGATGAGAA CACAGAGCCA AACCATATCA ACTCTATCTT 000240
000241 CATGTTTGTT TACATTTCTC TCAACTGTAT GTTTTGTGAC CCAGAATGTG ATCCTGGTAA ACATTCCATT TGAGAAGAAT 000320
000321 GTGTATTCTG CTGTTGTTGG AAGCTGCGTT GTCATTGATG AAGGAATATT TCGAAGCGCT GAACAATTCT TGATAAAGTT 000400
000401 CCGAAACAAA CAAAGCACAA TCTTCCCTCG ATTTACATGG GAGTTGCATT CCTGGAAAAT TCAGTATATT TTAAAACCAT 000480
000481 GCAAAATATC CTTTTAAAAA AATATGTAAC ATGGAGTTTA GGACCAAGGC TCAGAATATT TCCAATCCAT GGTTGGGTGC 000560
000561 GGAACCTGCG GATACAGAGG ACTGACTATA ATATCAAGAG ATCATAAGGC TGTCGGAATG GACTCTTTGT GGCAATAAGA 000640
000641 TACCATATTA TAAACAGGAC CCAAGGTCAT GCCAGGAGGC TCGTGTGGTC CCTGTTTGTC ATCCAGTCAA TACGGCCATC 000720
000721 AGCTTCTGGC CCCAGACACC TTTCCTCTGC ACTGTGGCAC AGAGGAGCAG ACTGCTTTGG AGGGCAGCTT CCTGGGAGCT 000800
000801 CCAGGGACCC TGGCCAGGCG GCCACTGCCA CTGACTTCCT CGGCTCACTG AGCCCGTGCC TGCAGCTCTC GTGTTTCCTC 000880
000881 TGTGCTGCAG TGGACGCTTA TCTTCCCCCG ATGGCACATT TCTTTGTCAC AGACAGGACC CTCACTGGCA GTCGGAGGAC 000960
000961 ATCAAGCCCT AGTACAGGAA GGGACATTTT CACACTAATC TGTGCCAGCT GGAGCAGTCC TGCCATCTGA ACATCATATT 001040
001041 TTGGAACCCT GAGAAGCTAG GATGCAGTTA ACAGCTAGAT GTCAATTCCC TGCAGGCAGA GACCAGTTCT CTGCTGCCAT 001120
001121 GTCTTTAAGG CCTGATGCAC CATAGATTAA TTCAAATCCA GTGTCTACCA CTCACTCGGC TTAATGTAAG ACAAGATGAA 001200
001201 GACTCCAGAC TTCAGAACTT CAGTGTCCGC AGATGAGGAT TTTAAATGCT TCGCCTACAA CCTCAATTGT TGTGGAGCCA 001280
001281 AAGATGCAAC AGCTTTGAAG AATAGAAGAA TTACTCTATA TTTGTCAGGA TCTACGTGGC AAACAAGCGC CACTTGGCTT 001360
001361 ACATTACTTG CCTGGCTTGG ATCCCATGGA ATGGAGGAGC ATTGGAACCA AGAGGAAAAA AATTAAAGTG CTTTGGGACA 001440
001441 GCGAGCCAAA CTCTTACATA GTATTTGAAA TGGTGTGGCA AACATGAAAT TATTTTAGGC TCAAGATTGG TGCTAGTTTT 001520
001521 TTACCCTCTT TTTGAAAAAA TAGTAAAATG CACATAAAGG GCCCTGCCAG AGGTTTAGCT CATAAAATCT GCCAATCATT 001600
001601 GGATGTGCTA ATTGGTGTAG CAATCCAGTG GTGGCCTGGA TTAGGACTCA AAAACTGACC CTTACCACCC TTGGTGTCCT 001680
001681 GCAGCAAAGA CAGCCTAAAT CGAAAAGACT GATGGAAGTA TATCAAATTA CGAATTTCTC TATCCCTGAA AAATGCCTGC 001760
001761 AATTTCTGTT TCTCCATCAC TCCAGAAATA CTCAAAACAG CAAAAATTAA ATACATATGA AGTGAACACA AAAGACCTCC 001840
001841 ACAGAAAAAT CAGTGGCTCA TCTGTTGACG CTATTGCTCA TTGCTCGGCT GGCCAGTCAT CTGGGCTAAG TTTTGACTTT 001920
001921 GGGCCAGTGC TTCAAAATCA GCAACCTTTC AGCCAAAAGA CTGTGGAATG CAGCCAAGAC CACCTGTGGA AAGTGAATTA 002000
002001 TAGCATCTTT AATTTACTAC CTTGGGCTAT GATGTCAGAA ACCCAGCATG GAGGGCGCAC CAGTTCTTGT GTGGGAAATC 002080
002081 TCTCAGAGCC CCCATGGAGG CCCCCAAAGT GGCTCTGGCA AAGCTGTAGG GGTGGAGGTA ACAAAAAAGG GGACACCTGG 002160
002161 CTCTCCTTCT TAAATCAGCT CACCATGGGC ACACATTTAT ATTGGAATTT TAGGGTCAGA AAATACCAAA ATTAAATCTT 002240
002241 CTAGAAG

Labs working on this lncRNA

  • Cancer Research UK, Robinson Way, Cambridge CB2 0RE, UK.

References

  1. ↑ 1.0 1.1 1.2 1.3 Niemczyk M, Ito Y, Huddleston J, Git A, Abu-Amero S, Caldas C, Moore GE, Stojic L, Murrell A. Imprinted chromatin around DIRAS3 regulates alternative splicing of GNG12-AS1, a long noncoding RNA. Am J Hum Genet. 2013 Aug. 8;93(2):224-35

Predicted Small Protein

Name GNG12-AS1_smProtein_203:496
Length 97
Molecular weight 11250.0757
Aromaticity 0.144329896907
Instability index 42.2989690722
Isoelectric point 9.30047607422
Runs 14
Runs residual 0.0127911416571
Runs probability 0.0759393847631
Amino acid sequence MRTQSQTISTLSSCLFTFLSTVCFVTQNVILVNIPFEKNVYSAVVGSCVVIDEGIFRSAE
QFLIKFRNKQSTIFPRFTWELHSWKIQYILKPCKISF
Secondary structure LLLLLEEEEEHHHHHEEEEEEEEEEEEEEEEEEELLLLLEEEEEEEEEEEELLLHHHHHH
HHHHHHHLLLLLEELLLLLHHHHHHHHEEELLLLLLL
PRMN LLLLLLLLLLLLLLLLHHHHHHHHHHHHHHHHHHLLLLHHHHHHHHHHHHHHHHHHLLLL
LLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLL
PiMo ooooooooooooooooTTTTTTTTTTTTTTTTTTiiiiTTTTTTTTTTTTTTTTTToooo
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