GSEC

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Annotated Information

Name

GSEC:G-quadruplex forming sequence containing lncRNA

FLJ39051[1]

Cellular Localization

FLJ39051 is a previously uncharacterized cytoplasmic lncRNA and also called GSEC(G-quadruplex-forming sequence containing lncRNA).[1]

Function

Effects of GSEC knockdown on colorectal tumor cell motility[1].

knockdown of GSEC by small interfering RNA (siRNA) can result in the decreased motility of DLD-1 cells. Similar results is obtained with the colon tumor cell line SW480.knockdown of GSEC expression by siRNA can lead to a decreased rate of wound healing. However, GSEC knockdown do not affect the proliferation or adhesion of DLD-1 cells suggest that GSEC plays an important role in the motility of colon cancer cells. In addition, GSEC can bind to the DEAH box polypeptide 36(DHX36) RNA helicase via its G-quadruplex-forming sequence and inhibits DHX36G-quadruplex unwinding activity. Moreover, knockdown of DHX36 restores the reduced migratory activity of colon cancer cells caused by GSEC knockdown.[1]

Expression

The expression of GSEC is upregulated in human colorectal cancer compared with surrounding nontumor tissues .[1]

Diseases

Colorectal cancer[1]

Sequence

>NR_033839.1 Homo sapiens G-quadruplex forming sequence containing lncRNA (GSEC), long non-coding RNA

000001 AGAAAGGGCG GGGTGGAGGA GGGGGAAGGG CGGGGGTGAT GCCGCGCGGT CGCAGGCTTG GGATGGTGTT CGCGCCTCCG 000080
000081 AGACCCGGAC AGAGGCAAGC AGGGGCGCCG TGGGTGCCAG AGAGGCGGAA GAGGAGGCCT GATGGGGATA CCTTCCTGCT 000160
000161 GTCCTTCCTG AGCACAACCT GGCTGAAAAC CTGGAGGTCA CAACAGTACA AAGAATCAAA GTCAAGATCT TGTGCCAGAG 000240
000241 AGCAAATGAA CTCTTCCTCT TGCTGAGAAA ACCCACCCTG CTCACCTAAA CCCTGGCCTT GCCTGGTAAT TCCATCCATG 000320
000321 CGCCTGGAAG GCCCCAGACA TCAAGGCTCT GAGGGGCCAG GCACGGGGAG AACCCAGCAG TGCCCTGCCC TGCAGTCTGA 000400
000401 GCTACCAGAT TCCTTGTGAA GATAATTTGA GGACCATGAC TCACCCAACC ACATTTCCTG GGGCCTCAAA TTGAAAATTC 000480
000481 AGGATGGGCT TTTCTATATG ACTGGCTGAT ATCCAACTAT GCCATGGTCT TTACATGCCA TGAACATTCT TTCCTGCCAG 000560
000561 AGTTCTAAGA ATCTGTGTTC TCTGCCTTAG ACCTTCTGCA GATGAGCCCA CAGGAAGCTC CACGTGTAGC TGAGCTACAT 000640
000641 GCACCAGGCC TCAGTTTGCC CCAAGTCCCC TGTGTACTCT CTCATGGCCT GTGGCCAAGA AATGTATTCT CTCACTTTGG 000720
000721 ACTTAGGAGT CCAAAGAGAA GCCCAGAAAC AAA

Labs working on this lncRNA

  • Laboratory of Molecular and Genetic Information, Institute of Molecular and Cellular Bioscience, The University of Tokyo, Tokyo, Japan.

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Matsumura K, Kawasaki Y, Miyamoto M, Kamoshida Y, Nakamura J, Negishi L, Suda S, Akiyama T. The novel G-quadruplex-containing long non-coding RNA GSEC antagonizes DHX36 and modulates colon cancer cell migration. Oncogene. 2017 Mar 2;36(9):1191-1199.
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