KDM7A-DT
A rapid downregulation of a long non-coding RNA, lncRNA KDM7A-DT, when PDLSCs were treated with hydrogen peroxide, which was negatively associated with PDLSC apoptosis.[1]
Contents
Annotated Information
Name
Approved symbol:KDM7A-DT
Approved name:KDM7A divergent transcript
HGNC ID :HGNC:48959
Previous name:JHDM1D antisense RNA 1 (head to head)
RefSeq ID:NR_024451
Characteristics
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Function
KDM7A-DT play a protective role in ROS-induced apoptosis, and KDM7A-DT/DNAJC10/phosphorylated-eIF2α/Bcl-2 pathway works as an anti-apoptotic signaling axis in PDLSCs.[1].
Regulation
HDM1D-AS1 regulated PDLSC apoptosis via inhibition of DNAJC10, a heat shock protein 40 family member. [1]
Expression
A rapid downregulation of a long non-coding RNA, lncRNA KDM7A-DT, when PDLSCs were treated with hydrogen peroxide, which was negatively associated with PDLSC apoptosis. [1].
Diseases
- periodontal ligament repair.[1]
Labs working on this lncRNA
- Department of Implantodontics, Stomatological Hospital of Chongqing Medical University, Chongqing, 400016, China.[1]
- Department of Endodontics, Stomatological Hospital of Chongqing Medical University, Chongqing, 401147, China.[1]
- Department of Orthodontics, Stomatological Hospital of Chongqing Medical University, Chongqing, 401147, China.[1]
- Department of Periodontitis, Stomatological Hospital of Chongqing Medical University, Chongqing, 401147, China.[1]
- Department of General Dentistry, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hanzhou, 310051, China.[1]
- Department of Endodontics, Stomatological Hospital of Chongqing Medical University, Chongqing, 401147, China. Electronic address: Gan824@126.com.[1]
References
- ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 Shi B, Shao B, Yang C, Guo Y, Fu X, Gan N. Upregulation of JHDM1D-AS1 protects PDLSCs from H2O2-induced apoptosis by decreasing DNAJC10 via phosphorylation of eIF2α. Biochimie. 2019 Oct;165:48-56. doi: 10.1016/j.biochi.2019.06.018. Epub 2019 Jul 2. PMID: 31276733.
