LDLR-AS1
A long non-coding RNA (lncRNA; LDLR-AS1) functions as an endogenous epigenetic regulator of LDLR and that the repression of this lncRNA by the action of small interfering RNAs (siRNAs) results in the activation of LDLR. [1]
Contents
Annotated Information
Name
Approved symbol:LDLR-AS1
Approved name:LDLR antisense RNA 1
HGNC ID :HGNC:54407
Alias symbol:BM450697
RefSeq ID:NR_163945
Characteristics
Please input information here.
Function
Please input information here.
Regulation
LDLR-AS1 functions as an endogenous epigenetic regulator of LDLR and that the repression of this lncRNA by the action of small interfering RNAs (siRNAs) results in the activation of LDLR.[1]
Expression
Please input information here.
Diseases
- Hypercholesterolemia [1].
Labs working on this lncRNA
- Center for Gene Therapy, City of Hope, Beckman Research Institute and Hematological Malignancy and Stem Cell Transplantation Institute, 1500 E. Duarte Rd., Duarte, CA, 91010, USA.[1]
- Department of Chemistry, Technical University of Denmark, 206 Kemitorvet, 2800 Kgs Lyngby, Denmark.[1]
- Center for Gene Therapy, City of Hope, Beckman Research Institute and Hematological Malignancy and Stem Cell Transplantation Institute, 1500 E. Duarte Rd., Duarte, CA, 91010, USA. Electronic address: kmorris@coh.org.[1]
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Ray RM, Hansen AH, Slott S, Taskova M, Astakhova K, Morris KV. Control of LDL Uptake in Human Cells by Targeting the LDLR Regulatory Long Non-coding RNA BM450697. Mol Ther Nucleic Acids. 2019 Sep 6;17:264-276. doi: 10.1016/j.omtn.2019.05.024. Epub 2019 Jun 7. PMID: 31279228; PMCID: PMC6611981.
