LINC00210
Contents
Annotation
Name
Approved symbol: LINC00210
Approved name: long intergenic non-protein coding RNA 210
HGNC ID: HGNC:37458
Previous symbols: NCRNA00210
Previous names: non-protein coding RNA 210
Alias symbols: RP11-72L13.1
RefSeq ID: NR_048550
Characteristics
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Expression
NCRNA00210 increased in A549/CDDP (all P <0.05)[2].
Highly expressed in liver cancer and liver TICs[1].
Regulation
Please input regulation information here.
Function
Linc00210 drives the self-renewal and propagation of liver TICs through activating Wnt/β-catenin signaling. Linc00210 interacts with CTNNBIP1 and blocks the combination between CTNNBIP1 and β-catenin, driving the activation of Wnt/β-catenin signaling. Linc00210-CTNNBIP1-Wnt/β-catenin axis can be targeted for liver TIC elimination[1].
Disease
non-small cell lung cancer [2]
liver cancer[1]
liver TICs[1]
Evolution
Please input evolution information here.
Labs working on this lncRNA
- Beijing Key Laboratory of Respiratory and Pulmonary Circulation, Capital Medical University, Beijing, China.
- Department of Cancer Biology Immunotherapy, The Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital, 127 Dongming Road, Zhengzhou, Henan, 450003, China.
- Department of Histology and Embryology, College of Basic Medicine, Zhengzhou University, 100 Kexue Road, Zhengzhou, Henan, 450052, China.
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Fu X, Zhu X, Qin F, et al. Linc00210 drives Wnt/beta-catenin signaling activation and liver tumor progression through CTNNBIP1-dependent manner[J]. Mol Cancer, 2018, 17: 73.
- ↑ 2.0 2.1 Yang Y, Li H, Hou S, et al. The noncoding RNA expression profile and the effect of lncRNA AK126698 on cisplatin resistance in non-small-cell lung cancer cell[J]. PLoS One, 2013, 8: e65309.
>NR_048550.1 Homo sapiens long intergenic non-protein coding RNA 210 (LINC00210), long non-coding RNA
000081 ATTAAATAGT GATGCTACCC AAATCCAGGC TTGTCCTGTG CTTGATGGCT GCTGCTATTG CTCCACAGAG ATGCCTCTTC 000160
000161 CCAACCAGAA ACTGTGTTAA CCGACTCTCA CACTGACTTC CAATCCTCAC CACAACCTTG CGAGGTCGGT ATTATGACCA 000240
000241 CTACTTTACA GGCCCTTCTG GTATGCACAG CTAACAGTCT AGTGTGCCAA GACTGTGCCA GCCTGGAGAA ACTTCGTGGG 000320
000321 CTATCTCAGG CTCCATCTAG CCTTCGACAC TCAGGCTTAT AAGGGTGAAG GAGAAACTGA GGCACAATAT CATGAGTTCA 000400
000401 CATGGAAAAA TCATGAGTAC ACATGGAAAA AAGGTAGAAT TTTTGACGTG AATTATCTCA GTTTATATAT ACCTTTTAAA 000480
000481 ACTTTTTCCT ATGTTTTCTC CTATTTACAC ACCGTCTGCC CTGTGGGCTG TGGTGCACAT TGACATGTGT TATTGCATTG 000560
000561 TCGCTATCCT ATTTTTCCAG GTAAGGATGG TGAAACTCGG AAAGGTTAAG TCACTCAGAC CCAGCATGCA GTGTCGTTTC 000640
000641 CCTCTGCCCG CTGCCTGTGC TACACATTCT GGGCGCTGTT GCTGAGCTCC GCTCAATGGC TTTACGCCTC CCTTTCAGGG 000720
000721 AAAAGCAGCT GCACTGAAGT TCTGTAAATG CTGTAATAGA AGTTGTTAAC CACTTCCACA TGATTTTTAA AGTAAATGTC 000800
000801 ACACTGCATT GTAACAGTGA GCTAACAACA CGTTAGCGGG TTCTCATTCT CATTTAATTC ACTTTTCCAA TACGGAAGTT 000880
000881 ACTGTGATGC CTGCAAGGAC GGCCACGTTC AGTGAATTAC TTGGCAGCTG GGCCATTTAT TTCTTCACTT CTCCCTTGCT 000960
000961 GCCTCCCTCG GTGGTTTTTG AAGTTTAGTT ATTGCTATGC TTCCTCTCAT GCTGCTATCC GAGGGAGAAT GGAACTGTTG 001040
001041 GTTTCAGCAG CAGTCAGATC CTCACCATTC CAGCCTGGCT GCGGAAGCGC CCACTAGTTC CCTTTGTCTG CTGCTCTGCC 001120
001121 CAGAGCTGGA AGCATAGGCT GAGCGGCTGC TGGCTGTCAG CTTGCAGCGT CTGATATTGT TAGGAGACGA ATTATGCCCC 001200
001201 TCCTGCCCCC CCACTGCCCT CAATTTGTAT GTTGAAATCC TAATCTCTAG TACCTCAGAA TGTGATCTTA TTTGGAAACA 001280
001281 GGTCCATTGA AGAGGTAGTT AGTTAAGTGG AGGTCATATT GGAGTAGGCT GAGTGAGCCG CTAATCCAAC ATGACTGGTG 001360
001361 TCCTTATAAA AAGGGACAAT GTGGATGCAG AGACACACAC AGGGAGAATA CCATGTGAAG ACTGGAGTTA TTCAGCCACA 001440
001441 ACTAAGGCAT TTCCAGAAGC CAGGAGAGAG GCTTGGAACA GATCCTTCCC TAGAGCCTTC AGAGGGTGTG TGGCCCCGCT 001520
001521 GACACTGACC TCAGACTTCC AGCCTCCAGA GGTGTGAGAT GATAAATTTC TGTTGCTTAA ATGAAAAAAA AAAAAAAAAA 001600
001601 AAAA
