LINC00266-1
LINC00266-1 encodes a 71-amino acid peptide,named "RNA-binding regulatory peptide" (RBRP) which promotes tumorigenesis. [1].
Contents
Annotated Information
Name
Approved symbol：LINC00266-1
Approved name：long intergenic non-protein coding RNA 266-1
HGNC ID ：HGNC:16202
Previous name：chromosome 20 open reading frame 69|non-protein coding RNA 266|non-protein coding RNA 266-1
Alias symbol：bA476I15.3|RBRP
RefSeq ID：NR_040415
prev_symbol C20orf69|NCRNA00266|NCRNA00266-1
Characteristics
The long noncoding RNA (lncRNA) LINC00266-1 encodes a 71-amino acid peptide.The peptide mainly interacts with the RNA-binding proteins, including the m6A reader IGF2BP1, and is thus named "RNA-binding regulatory peptide" (RBRP). [1].
Function
The oncopeptide RBRP encoded by LINC00266-1 is a regulatory subunit of m6A readers and strengthens m6A recognition on the target RNAs by the m6A reader to exert its oncogenic functions. [1].
Regulation
RBRP binds to IGF2BP1 and strengthens m6A recognition by IGF2BP1 on RNAs, such as c-Myc mRNA, to increase the mRNA stability and expression of c-Myc, thereby promoting tumorigenesis.[1]
Diseases
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Expression
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Labs working on this lncRNA
- Biomedicine Research Center, Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Degradation, State Key Laboratory of Respiratory Disease, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510150, China. [1]
