LINC00319
Contents
Annotation
Name
Approved symbol: LINC00319
Approved name: long intergenic non-protein coding RNA 319
HGNC ID: HGNC:19730
Previous symbols: C21orf125; NCRNA00319
Previous names: chromosome 21 open reading frame 125; non-protein coding RNA 319
Alias symbols: PRED49; FLJ38036
RefSeq ID: NR_026960
LncBook ID: HSALNT0289323
Characteristics
Long intergenic non-protein coding RNA 319 (LINC00319) (NR_152722), is located on chromosome 21q22.3 and has a transcript length of 2901 nucleotides[1].
Expression
LINC00319 was significantly up-regulated in lung adenocarcinoma tissues compared with normal lung tissues[1].
Reported to be highly expressed in lung cancer[2].
Regulation
Please input regulartion information here.
Function
Linc00319 promotes cell proliferation and invasion in lung cancer cells by directly binding with and downregulating the tumor suppressor miR-32.[2]
LINC00319 was also shown to regulate the miR-450b-5p targeted gene enhancer of zeste homolog 2 (EZH2) by functioning as a competitive endogenous RNA (ceRNA) for miR-450b-5p in lung adenocarcinoma, thereby inhibiting the expression of EZH2 and promoting lung adenocarcinoma cell proliferation.[1].
Disease
lung cancer [2]
lung adenocarcinoma carcinogenesis [1]
Evolution
Please input evolution information here.
Labs working on this lncRNA
- College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi 712100, China.[2]
- Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang 441021, China.[1]
References
- ↑ 1.0 1.1 1.2 1.3 1.4 Zhang ZW, Chen JJ, Xia SH, et al. Long intergenic non-protein coding RNA 319 aggravates lung adenocarcinoma carcinogenesis by modulating miR-450b-5p/EZH2[J]. Gene, 2018, 650: 60-67.
- ↑ 2.0 2.1 2.2 2.3 Zhou B, Yuan W and Li X. Long Intergenic Noncoding RNA 319 (linc00319) Promotes Cell Proliferation and Invasion in Lung Cancer Cells by Directly Downregulating the Tumor Suppressor MiR-32[J]. Oncol Res, 2017.
Sequence
>NR_152722.1 Homo sapiens long intergenic non-protein coding RNA 319 (LINC00319), long non-coding RNA
000081 CTTGGGCCGG TGTGAAGCCA CCCCCCTGCC ATGAAAAATG GCTCTTCCCT GCCACAGCCG GCCCAGCGGG AGCCAGGTCA 000160
000161 GGGCCTGGAG ACACAGCGCC CCCCACCGGA GCCACTGCCC GGCCCAGCAG CACCTGCGGA GAATCCCACC AGCTCCCACG 000240
000241 CCTCCCGCCG CGCCACCGCC CCGGCTTTCT GCAAATCCAC CTTATGGAAG CCGGATAAGC ACCTCCTCCT CTGATGCGTC 000320
000321 ACAGTCACAG GTCCTGGTGA GGAGGGAGCC ACGCCAAGCA CAGCGGCTGG AACAGGGGCA AGTGGGTGCC CACCCCGAAG 000400
000401 TGCAGGCAAT GAACTTGTGC TGTAGCCCAT GGTGAGCTGT GGGGCTGTTT GTGACTGCAG CGTAGCCAAG CCCATCCCGC 000480
000481 CTGATGCGGC CTCTTCATCC AGAGTGGGGG TGACGTGCCA GCCCCCACCT CACCGGAATG CTGGGAGGAG CGTCTCCACG 000560
000561 GAAGGAGCTC ACTTTGTCAG CTGTAATGTG CTGTGACTAT CGTAAAGTTC CTTCCGGGTG CAGAGTGATA CATGAACCCT 000640
000641 GGGGACTCAC TCCAACTTGG TATTGATTTT CTCCACGGAG GACCCAGCAG TCACGGCCCG TGTCTGCACA GCCCCTTGGA 000720
000721 TCCTGCGGAG GAATTCAGCC GGCCCCTCCC CCTGTGCCGA AAACCACGGA GGCAAAGCCA GGCCAGGGTA CAGTGAGAAC 000800
000801 ACGGGAGAGG ACTGAGAGAC CGCTGGCTGC CGAGGGAGGA AGAGCAGGAT TCGCACCCCC GTCATCGCTG GGCCCACACG 000880
000881 CCGCCGACAG CTTCCGCGTG TGGCCATCTG TCTTTCAGAA ACCCTCTGGC AGAGGGACCC AGCAGATGAC ACGGGGGCCG 000960
000961 TTCACACTCT GAAACCTGCC TGGAGTCAAA ACACTGCTGG CGAGCCTCCA CCGCAAACCC AATCCAGATG GTCTTCCCTG 001040
001041 GTGGCCCTCG GGGTGGCGGG CACCCTGCCC ACTCCCTGCC AGCCCCTGCC CGCTGGACTC CAGGCCCGGC CGAGCCCCCG 001120
001121 ACCGGTCTCC TGACCCAGCA TGCTGCTCTC CCCTGGGCCC GGCTTTCTCG CCCGCTGGGA CTCCCAGGCC CCTCCAGCCC 001200
001201 AGCCCCGAGA GCAGGAGCCC CAAGGGAGGC TTGGCGGCTG TGGAGGCGAG TGGGCCACGT GTAGCTGGGA GGCCGGCAGG 001280
001281 ACCAGGAGCC CCTCACAGCG CAGCACCCAC AGCATCACGA GCCACTTCCA CTCCTGGGTG GCCTGGGGGC CCCCACCCTG 001360
001361 CTCTGAGCTG CCCCTTGTTG TGACCTGGGG TCCCCCGTGG TGGGCCCGCC CCTTGAGCCT GGGATCCAGC CTCAGCGAGG 001440
001441 CTCCAGAAGT GTCGTCTCCG CCGGCCAGGC GTCAGCGCCT CCACCCAGGA TCACACACTC CTATCTCTGC ACTTCTGCCC 001520
001521 TCCATCCTGC TCCACGCCGC CTCTGCTTGT TATTCCAGCA CATTCCAGGG TGATGCCTGC TGAAGCCACG CAGCCAGTGC 001600
001601 CTCCACCCTA CCCCCCATCT GACCCACCGG CCCCTTCCGC ACGCTGGAAG CCTGCCCGGC CTGAAGTGTC CTCACCTGTC 001680
001681 GCCCTATCCT CCCCTCCACT CCAGCCCACC GGTGACTCAG CCCTCACAGC TCTCTCCTCC CCGAGGGAGC CGGTGACTTG 001760
001761 GCTCTGATGG TGCCGGGACC CAGCCCCGGC ATGTTCAGAA TCCTTGTCCT TTAACCTGCG TCCACATGTA GTCGCCTCCA 001840
001841 CCTCCCTGCC TGAACCTCCA GGCCCTGCAG AGCAAACACT GCTGCCTGCA GGAGACCCCT GGGGCCTTCT CCGTCCCCTC 001920
001921 ATCCTCCTAA GGAGCCTCCC CTGCCACCGT GCCAGAATGT GCCGGAGGAA CAGAGGCCCG AGCCTCCCGT GGCCCCAGCG 002000
002001 AGGCTTCCTC TGGGGAAGAC AGTGAGCCCA ACGCCCTGGC TCTCGAGGGG TGGACGGAGT CCAGCTGGCA TCGACCGGGT 002080
002081 GCCCCTCTTC ACCGGTGTCC ACAGTCCTTG AGAGCAAAGG GTTCCCAGAG GCGACCTCCC TCCTGCACAG GCATTTGTCA 002160
002161 TCCTTACCCT CTAGGACAGC TTTGCCATGT GCAGTGAACC CCTGGACAGT GTTGCGTGCC ACTTTGCCGG ATTTGGACTG 002240
002241 TATACAGACC GAAGCATGTG GCATGAAGCC TTCTGCTGTC AGCAAGTTCC TTGTCCCTCG ACAGTATGTG CCCAGGCTGC 002320
002321 CCTTCAAGGT GGCAGTGATG GCAGTTGTCT CTTGCACGCT GCGTACAGTT CTGTCACTGA CTCTTACACA CAGCCCTGGA 002400
002401 GACGGGAGAG TGCCGGGAGC ATTCTATGCA AGTGTCCTGG CCTTTGCGGG CGTCTCCACA GCACAAACAC GAGTCAGGGA 002480
002481 CCACCCCTCT TCTGCTTCCA TGATTCCACC AACTGGGTGG GGCAGAGCAG TGCCAGGGCC GGAGGCACGC CCCAGGTGAG 002560
002561 GGCAGGTGGC CATGCCAGTG AGTGCACTGC GTTCTCAGTT AATTCATCCG AAATATTTCT AAGTTTCTTG ATTATTGCAG 002640
002641 TTGCATCCCC AAGATAATGC CGCCCTCACC AAGTAGAAGG CACATGTGCT CTGATGGCCC CTCCCACACT GGGGTCAGGG 002720
002721 CACAGCAACT TAGCGAGGCG ACGTGGGGGC TCAGAGGACC TCGGACCAGG CTCGGCACAT GGGGCTTCTC CAGCCAGCCA 002800
002801 GGGGGAAGCA CCCTGCAGAC TGCTAACTTT TGCAAAATAG AGTAAAAAAG ATCAGCTAGA AAAATAAAAC AAAAAAGGAA 002880
002881 AGATATACAA AATACAAGGC C
