LINC00458

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LncRNA ES3 was significantly upregulated in HER2-positive breast tumors and may contribute to breast cancer proliferation as a downstream target of HER2. [1].

Annotated Information

Name

Approved symbol:LINC00458

Approved name:long intergenic non-protein coding RNA 458

HGNC ID:42807

Alias symbol:LncRNA-ES3|ES3

RefSeq ID:NR_108062

LncBook ID:https://bigd.big.ac.cn/lncbook/gene?geneid=HSALNG0097328

Characteristics

The long noncoding RNA (lncRNA) LINC00266-1 encodes a 71-amino acid peptide.The peptide mainly interacts with the RNA-binding proteins, including the m6A reader IGF2BP1, and is thus named "RNA-binding regulatory peptide" (RBRP). [2].

Function

LINC00458 has diagnostic value in breast cancer diagnosis. [1].

Regulation

Please input information here.

Expression

ES3 upregulation in breast cancer .[1] ES3 expression downregulated during neural differentiation.[1]

Diseases

Breast cancer.[1]

Labs working on this lncRNA

  • Stem Cell and Developmental Biology Group, Genome Institute of Singapore, Singapore.[2]
  • Department of Biotechnology, Institute of Science and High Technology and Environmental Sciences, Graduate University of Advanced Technology, Kerman, Iran.[1]

References

  1. 1.0 1.1 1.2 1.3 1.4 1.5 Keshavarz M, Asadi MH, Riahi-Madvar A. Upregulation of pluripotent long noncoding RNA ES3 in HER2-positive breast cancer. J Cell Biochem. 2019 Oct;120(10):18398-18405. doi: 10.1002/jcb.29152. Epub 2019 Jun 18. PMID: 31211468.
  2. 2.0 2.1 Ng SY, Johnson R, Stanton LW. Human long non-coding RNAs promote pluripotency and neuronal differentiation by association with chromatin modifiers and transcription factors. EMBO J. 2012 Feb 1;31(3):522-33. doi: 10.1038/emboj.2011.459. Epub 2011 Dec 23. PMID: 22193719; PMCID: PMC3273385.