LINC00858
LINC00858, a competing endogenous RNA for miR-422a to facilitate the cell growth in non-small cell lung cancer.
Contents
Annotated Information
Approved Symbol
Approved symbol：LINC00858
Approved name：long intergenic non-protein coding RNA 858
HGNC ID：HGNC:27276
Alias symbol：CRCAL-2
RefSeq ID：NR_038220
Characteristics
Long intergenic non-protein coding RNA 00858 (LINC00857, LOC170425, NR_038220), is a kind of lncRNA whose length is 2685 nucleotides and locates in 10q23.1. [1] LINC00858 was identified to sponge miR-139 to form RISC using luciferase reporter and RIP. [2] LINC00858 has been implied to function as an oncogene. [1]
Function
LINC00858 function as a competitive endogenous RNA (ceRNA), effectively becoming sponge for miR-422a and thereby modulating the expression of kallikrein-related peptidase 4 (KLK4). [1] LINC00858 facilitates tumor NSCLC cell growth in vitro. [1] LINC00858/miR-139/CDK14 regulates the osteosarcoma proliferation and invasion. [2]
Regulation
NA
Diseases
Expression
LncRNA LINC00858 was significantly upregulated in both osteosarcoma tissues and cell lines. [2] LINC00858 is highly expressed in lung adenocarcinoma (5.23-fold than normal lung tissues). [1]
Labs working on this lncRNA
- Department of Orthopedic, The 117 Hospital of The PLA, Hangzhou, Zhejiang, 310012, China
- Department of Cardiothoracic Surgery, ZhongNan Hospital of Wuhan University, 430071 Wuhan, P. R. China
- Department of Oncology, Hubei Provincial Hospital of Integrated Chinese and Western Medicine, 430015 Wuhan, P. R. China
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Zhu SP, Wang JY, Wang XG & Zhao JP. Long intergenic non-protein coding RNA 00858 functions as a competing endogenous RNA for miR-422a to facilitate the cell growth in non-small cell lung cancer[J]. Aging-Us. 2017, 9(2):475-486
- ↑ 2.0 2.1 2.2 2.3 Gu ZH, Hou ZH, Zheng LB, Wang XQ, Wu LB & Zhang C. Long noncoding RNA LINC00858 promotes osteosarcoma through regulating miR-139-CDK14 axis[J]. Biochem Bioph Res Co. 2018, 503(2):1134-1140.
Sequence
>gi|170425|ref|NR_038220.1|Homo sapiens long intergenic non-protein coding RNA 858 (LINC00858), long non-coding RNA
000081 TCTGAGTTAG GCTTGGCCAC AAGAGACAAA TTGCAAGGCA TGGAGACATT TTTCTAACAC TTGAAAATTC TATGCAAGAG 000160
000161 CACCAGGCAG CTCAGTCACC TTGTCACTTA TCTACTGGGT CACCTTGTTG GCATGGGATG CCAGCCAGGC TTGCAGCTGC 000240
000241 TCCATCCTCC CCTGAATTTG TACTTCAGCT TCTCCACTCA TGGCCTGCCC TGAGGACTTC ATGGTTCAGC ATCAGATATG 000320
000321 AAGACGACAG CCCTATAGAG ACTATTTAAC CAGCTTCTAA GGTGGTTAAA TATCTTACCA GCCTATGTAA GGCCGAATCC 000400
000401 TACTAACAAA GCACTGGTAT ATGTAATATC CCAGTGGTTT GCTTCTCTAA TTGAACCCTG ACTACTACAG AAGTCCAGAT 000480
000481 ACCACAGTCT GAGTAGTTCT TTAATCTGCT TATCTGGTGA TTCCATCACA AATGGTTCAG TTGGGCAAAA GGCTCCAGTG 000560
000561 AAGAGCTGTG AGGCTTATGT ATGGGGACTC ACCAGGGGCC AGCCCAGGCT GCCCACAAGA CCATGAGCCA CCCTGTGACT 000640
000641 GAATGAAGTG GAGAGAAGGG AAAGTAGTTA AGAAATCAAG AAAAGTGTCT TTCAGCACCA TGGCCAGAAG TTGTGCCACA 000720
000721 GAATTGGAAC AGGGAAACCC AGAGAGCCAG TGCTGTCCTA GTCCTAGTGC TGAATGATCC CATTGGTGTC CTTAGAAGGG 000800
000801 CTCTGACTTC AGCCCACCAG CAGCATGTGG ACTTATAAGC TTTCTAGCAG AGTTGGAGAT CCCCAGGAAA AAGAAATCTC 000880
000881 TTAAAATGAA ATGAAACTTC AATCAACCAA GGCTTTCTAG CCTGATGTGA GTTGTCTTTA CACACATATA CCTTTTTAAC 000960
000961 AAAGAAGAAG AAAAGAATGG ACATTGATAG AACTTGCATT CTGTGTTCAT CACCAGGATA GTTGCTTTAT AAATATCATT 001040
001041 TTGTTTTTAG TCACAACCCA ATGCAGCATT TTCCTTACTG ACAAAGAACC TGAGGCATGG AGAATTTAAG CAACTCCCTG 001120
001121 AAGGCCACCC AGCTAATCAG CAGTGGGAAA AGAATTTAAT TCTAGATCTT TCATTCTAAA GCCCAGCTCC TTACACACGT 001200
001201 TGGATGCTAC TATTTCCAAA ATGTCAACAA CACTTTGGAC TATCAACCTG TCTAAAGAGT ATTTGAAGCA GTGATGCAGG 001280
001281 CCTCTGAAGG AAAAGGTGCA CATTTTCAAC AATAAAAGAG AGACATTCCT TTAGTGTATC TCCACATTCC CTGAAGGGGA 001360
001361 GCTGGAATGA CATGACGGAC TTGGCCTCAG GGCCCCAAGC CTTCCCTGTT GCAGTCTTCA TGACACTCCT CAGAAGCAGC 001440
001441 AACTCCAGCC ATGTCTGGAA CCATTCCTTA CCAGACAGGA GGATATCATG GCCTCAACTC ATGATCTGTA CCAAGCCAAA 001520
001521 CCTCTTTTGG GGTACCCACC AAGCCTCAGG CCTCACCTTC TCTGCCCTGT TGTCCCTGCC CATCTGTCCT GGTTTTCTAC 001600
001601 TAGTTTCCAC TACTGGACAC TTGTCTGAGG CTGGGTCCCC ACCTGGATCT TGTGGCCTCT TGCCCAGGGC TTGGAGGGAA 001680
001681 GCTGCTCCCA CACTTGAAGA TGACAGCTGA GCATGGTCCT TTGTGGGCGT GCTGTCAGGA AGATGACAGT GCAATCTGTT 001760
001761 TAATGTGCCA GTTGTCTCTG TGAGTCCCTC ATCCGGATGA GCACTTGTCA CACCCCTGCA GAGCCCCAGC TGGTTCTTAG 001840
001841 AGAGGTGCTC CAGCTCTGTG ATTACCTAAT CTGGCTTCCC AATCTATCCC ACAATGTGTC ATTGCTGAGG TCCCTGTGGG 001920
001921 TCTTGCAGAT AAACTTGCTA CAGTCATCCT ACACAAAAAA GAAGCTCGTT ATCATGAAAC CGGCCTGCTT TTTAGCTCCT 002000
002001 GGGCCCTAAC TCACCCCAGA TTGCTGCCAG CTCTTTTGTT TTCCCACTTA GACCAAAGGG ATTGAGAAGC TTTCCCATTC 002080
002081 CTTGGAGCTG CCACCCTCCA TTCTAAGGCA GTCTCCCCCT TCACCCTGCT TGCTGCACCC CAGATGCTGC AAGGCCCATG 002160
002161 TGCTGTTTTT GACTTCAGTA CTTCAGATTG CTGTGGGAAC ACAGGAGGCA GCAGCCAGAT GAGAAATTGA GTCTGACTCT 002240
002241 GGAGTATTAT AAAGTCCTTA TAGTTACTGG CATTAGGTAT AGGGTCTGTA TTATTAAAGA GAAATTATTC ACCAAACACT 002320
002321 TGTTAAAAAT GGCAAGACAG TTTATTTAAG AGCATTGCAA TAGGTAAGTG CTATGGTCTC AATGTTTGTG TCTCCCTCAA 002400
002401 ATTCATAAGT TGAAACTTCA CTTCCAAGAT GAAGGAATTA GGAGGTGGGC ACTTTAAGGG ATGATTATGT CATAGGCCAG 002480
002481 AGCCCTCATG AACGAGATCA GTGCCCTTCT AAAAGAGGCA TTGGGAGAGA CCCCTCACCT TTTCCATCAT ATGAGGACAC 002560
002561 AGCCAGGAAG CATCATCCAC GAACCAGAAA ATTGGCCCTT ACCAGACACT GAATCTGCTG ATGTCCTGAC CATGGACTTC 002640
002641 TGAGCCTTCT GAACTGTGAG AGATAAATTT CTGTTGTTTA TAAGC
