LINC01021
Contents
Annotated Information
Name
Approved symbol: PURPL
Approved name: PURPL : p53 upregulated regulator of p53 levels
Previous symbols: LINC01021
Alias symbols: LOC643401, RP11-46C20.1
HGNC ID: HGNC: 48995
RefSeq ID：NR_038848
Ensembl ID: ENSG00000250337
LncBook transcript ID: HSALNT0289082
Characteristics
PURPL is a p53-dependent transcription driven by a MER61C LTR. CMS4 tumors with low PURPL expression were associated with poor patient survival[1].
Function
- PURPL contributes to cellular survival in response to genotoxic stress by suppressing apoptosis[1].
Regulation
PURPL is activated by P53 in colorectal cancer (CRC)[1].
Diseases
Colorectal cancer (CRC)[1].
Expression
In CRC patient samples, PURPL expression positively correlated with a wild-type p53-associated gene expression signature. PURPL expression was increased in primary colorectal tumors and displayed a bimodal distribution that was particularly pronounced in the mesenchymal CMS4 consensus molecular subtype of CRCs[1].
Evolution
-
pubmed IDs
26183718, 29262524
Sequence
>gi|336391099|ref|NR_038848.1| Homo sapiens long intergenic non-protein coding RNA 1021 (LINC01021), long non-coding RNA
000081 TTGCCCAATA GAGCCCTGCT CTACTGACCC TTCAATGTGC CCGTGTGCCT AAATATTCCT GGTCGTGTGA AAAGAACCCA 000160
000161 GGTATTAGCT GAACTAAGGA GCACAATTCT GCAACATTTT GGCACCCAAA CACGGGGCTT GAGAAATGAA TGCAATTGGA 000240
000241 GAAACTGGTT GTTTTACCAG GCGTTGATTG GAAATGTGTG CTTCCCTTTA AGCAGTCAAG CTCAACTTGC AGAACTGATG 000320
000321 GGAACCCCTT GGGAAAACTG GCCTCAAATG TTTGTCTACA CAGTCCACAT ACAGGGTTCT TAACCTGCGA TGAGGGAAAC 000400
000401 TTCCCAGGGC TTGTCTGGGT ATGCCCACAG TGGACTGGAG CCCAAAATGC ACACTGGAGG AAGTGGATGG AGCCACGTGG 000480
000481 ATGTCATGCC TTATGCAGGG GAGGAGCCTG CTCTCTTCAG CTCCTGTGGT AATGTGGGAA TCGATCTGTG AGCATATTTA 000560
000561 ACTATCCGGC TATTTTGGAG ATTGAAAAAA GAAGACCTGA TTTATCATGT GCAATATCTC ACACATCTGT CATTTCTATT 000640
000641 CTACCGCAAT TCGATGGAGT CTTGTTCTGT GGTCCAGGCT AGAGGGCAGT GGCATGATCT CGGCTCACTA CAAGCTCTGC 000720
000721 CTCCCGGGTT CACGCCATTC TCCTGCCTCA GCCTCCTGAG TAGCTGGGAC TACAGGCGCC CGCCACCACG CCTGGCTAAT 000800
000801 TTTTTGTATA TTTACTAGAG ATGGCTAGTG TTAGCCAAGA TGGTCTCGAT CTCCTGACCT CGTGATCTGC CCACCTCAGC 000880
000881 CTGCCAAAGT GCTGGGATTA CTGGCGTGAG CCACCGTGCC TGGCCAGCAT CCTCTAATTA TTATTCATAG TTTGTGAATT 000960
000961 TAGGCCTACG TGAATAATAA TATAATATTT ACTATGATGT TACTATCTAC CAACCTTATT TTTCTTTTCT ATAAAATAGG 001040
001041 AGCCAAAATA ATATTTATGT CATACCTTAT GAAGTTAAAA TAAAATATAA CGAATGAGGG GCTTAAAAAA AAAAAAAAAA 001120
Labs working on this lncRNA
- Experimental and Molecular Pathology, Institute of Pathology, Ludwig-Maximilians-University Munich, Munich, Germany.
References
Predicted Small Protein
| Name | LINC01021_smProtein_653:817 |
| Length | 54 |
| Molecular weight | 6173.0232 |
| Aromaticity | 0.148148148148 |
| Instability index | 66.1351851852 |
| Isoelectric point | 7.82427978516 |
| Runs | 11 |
| Runs residual | 0.0410117434508 |
| Runs probability | 0.0251240545358 |
| Amino acid sequence | MESCSVVQARGQWHDLGSLQALPPGFTPFSCLSLLSSWDYRRPPPRLANFLYIY |
| Secondary structure | LLEEEEEELLLEEELLLLLLLLLLLLLLHHHHHHLLLLLLLLLLLHHHLEEEEL |
| PRMN | - |
| PiMo | - |
