LINC01551
LINC01551 functions as an competing endogenous RNA (ceRNA) to regulate the miRNA target ADAM10 by sponging miR-122-5p and therefore promotes the development of HCC, highlighting a promising competitive new target for the HCC treatment.[1]
Contents
Annotated Information
Name
Approved symbol:LINC01551
Approved name:long intergenic non-protein coding RNA 1551
HGNC ID HGNC:19828
prev_symbol C14orf23
Previous name:chromosome 14 open reading frame 23
RefSeq ID:NR_026731
LncBook ID:https://bigd.big.ac.cn/lncbook/gene?geneid=HSALNG0100289
Characteristics
Please input information here.[1]
Function
LINC01551 promotes the development of HCC.[1].
Regulation
Upregulation of LINC01551 increased its ability of competitively binding to miR-122-5p, thus reducing miR-122-5p and upregulating ADAM10 expression, as well as promoting the proliferative, migrative, and invasive ability. [1]
Expression
High expression of LINC01551 and ADAM10 yet low-expression of miR-122-5p were revealed in HCC tissues and cells.[1]
Diseases
Hepatocellular carcinoma (HCC)[1]
Labs working on this lncRNA
- Department of Hepatobiliary and Pancreatic Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang, China.[1]
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Gao J, Yin X, Yu X, Dai C, Zhou F. Long noncoding LINC01551 promotes hepatocellular carcinoma cell proliferation, migration, and invasion by acting as a competing endogenous RNA of microRNA-122-5p to regulate ADAM10 expression. J Cell Biochem. 2019 Oct;120(10):16393-16407. doi: 10.1002/jcb.28549.
