LINC02476
LINC02476 may function as an oncogene in HCC progression and could serve as a novel diagnostic/prognostic biomarker and potential therapeutic target for HCC with MVI.[1]
Contents
Annotated Information
Name
Approved symbol:LINC02476
Approved name:long intergenic non-protein coding RNA 2476
HGNC ID:HGNC:53419
Alias symbol:LVCAT5|lnc-TSPAN12
RefSeq ID:NR_131962
Characteristics
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Function
LINC02476 knockdown inhibited HCC cell migration and invasion in vitro.[1].
Regulation
LINC02476 was significantly upregulated lncRNA in HCC. [1]
Expression
LINC02476 was highly expressed in HCC, including HCC with MVI, and its high expression was associated with unfavorable clinicopathological features and poor prognosis. [1]
Diseases
Hepatocellular carcinoma (HCC) with microvascular invasion (MVI) [1]
Labs working on this lncRNA
- Department of Bile Duct Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China.[1]
- West China-Washington Mitochondria and Metabolism Research Center, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China.[1]
- Department of Bile Duct Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China. Electronic address: nanshengcheng@163.com.[1]
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Lu J, Li B, Xiong X, Cheng N. RNA sequencing reveals the long noncoding RNA and mRNA profiles and identifies long non-coding RNA TSPAN12 as a potential microvascular invasion-related biomarker in hepatocellular carcinoma. Biomed Pharmacother. 2020 Jun;126:110111. doi: 10.1016/j.biopha.2020.110111.
