LINC02476

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LINC02476 may function as an oncogene in HCC progression and could serve as a novel diagnostic/prognostic biomarker and potential therapeutic target for HCC with MVI.[1]

Annotated Information

Name

Approved symbol:LINC02476

Approved name:long intergenic non-protein coding RNA 2476

HGNC ID:HGNC:53419

Alias symbol:LVCAT5|lnc-TSPAN12

RefSeq ID:NR_131962

Characteristics

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Function

LINC02476 knockdown inhibited HCC cell migration and invasion in vitro.[1].

Regulation

LINC02476 was significantly upregulated lncRNA in HCC. [1]

Expression

LINC02476 was highly expressed in HCC, including HCC with MVI, and its high expression was associated with unfavorable clinicopathological features and poor prognosis. [1]

Diseases

Hepatocellular carcinoma (HCC) with microvascular invasion (MVI) [1]

Labs working on this lncRNA

  • Department of Bile Duct Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China.[1]
  • West China-Washington Mitochondria and Metabolism Research Center, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China.[1]
  • Department of Bile Duct Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China. Electronic address: nanshengcheng@163.com.[1]

References

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Lu J, Li B, Xiong X, Cheng N. RNA sequencing reveals the long noncoding RNA and mRNA profiles and identifies long non-coding RNA TSPAN12 as a potential microvascular invasion-related biomarker in hepatocellular carcinoma. Biomed Pharmacother. 2020 Jun;126:110111. doi: 10.1016/j.biopha.2020.110111.