LINC02891
The lncRNA LINC02891 regulated by the oncogenic fusion protein might be functionally implicated in the biology of prevalent subtype of human leukemia. [1]
Contents
Annotated Information
Name
Approved symbol:LINC02891
Approved name:long intergenic non-protein coding RNA 2891
HGNC ID:HGNC:55221
Alias symbol:lnc-RTN4R-1
RefSeq ID:NR_038460
Characteristics
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Function
LINC02891 might be functionally implicated in the biology of this prevalent subtype of human leukemia.[1].
Regulation
LINC02891 is regulated by the oncogenic fusion protein.[1]
Expression
Sustained inactivation of LINC02891 in ETV6/RUNX1 positive cells caused profound changes in gene expression.[1]
Diseases
Pediatric B-cell precursor acute lymphoblastic leukemia[1]
Labs working on this lncRNA
- Department of Pediatric Hematology-Oncology and Stem Cell Transplantation, Ghent University Hospital, Ghent, Belgium.[1]
- Center for Medical Genetics, Department of Paediatrics and Genetics, Ghent University Hospital, Ghent, Belgium.[1]
- Department of Hemato-Oncology, HUDERF, Université Libre de Bruxelles (ULB), Brussels, Belgium.[1]
- Department of Hematology, University Hospital Brussels, Vrije Universiteit Brussel (VUB), Brussels, Belgium.[1]
- Department of Hematology, Children's Hospital, Toulouse, France.[1]
- Department of Hematology, Institut Universitaire de Cancérologie de Toulouse, University Toulouse-III Paul-Sabatier, Toulouse, France.[1]
- Department of Pediatric Hemato-Oncology, University Hospitals Leuven, Belgium.[1]
- Laboratory of Pharmaceutical Biotechnology, Department of Pharmaceutics, Ghent University, Ghent, Belgium.[1]
References
- ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 1.12 Ghazavi F, De Moerloose B, Van Loocke W, Wallaert A, Helsmoortel HH, Ferster A, Bakkus M, Plat G, Delabesse E, Uyttebroeck A, Van Nieuwerburgh F, Deforce D, Van Roy N, Speleman F, Benoit Y, Lammens T, Van Vlierberghe P. Unique long non-coding RNA expression signature in ETV6/RUNX1-driven B-cell precursor acute lymphoblastic leukemia. Oncotarget. 2016 Nov 8;7(45):73769-73780. doi: 10.18632/oncotarget.12063.
