LIVAR
Contents
Annotated Information
Name
LIVAR:liver cell viability associated lncRNA.
RP11-484N16.1 [1]
lnc18q22.2 [1]
Characteristics
The length of lnc18q22.2 transcript is estimated to be 633 bp [1].
Cellular Localization
Lnc18q22.2 is mainly present in cytoplasm [1].
Function
Lnc18q22.2 is significantly associated with NASH (Nonalcoholic steatohepatiti) grade, lobular inflammation, and NAS (AFLD activity score) [1]. In addition, lnc18q22.2 is also significantly associated with liver steatosis and steatohepatitis (including ASH (alcoholic steatohepatit) and NASH) [1]. Knockdown of lnc18q22.2 results in reduced growth in HepG2 and IHH cells and promoted cell death in Huh7 and Hep3B cells [1].
Expression
Lnc18q22.2 is predominantly expressed in liver tissue and in the HCC (hepatocellular carcino) cell line HepG2 [1].
Diseases
Nonalcoholic steatohepatiti [1]
Labs working on this lncRNA
- Department of Pediatrics, Molecular Genetics, University Medical Center Groningen, Groningen, The Netherlands.
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 Atanasovska B, Rensen SS, van der Sijde MR, Marsman G, Kumar V, Jonkers I, Withoff S, Shiri-Sverdlov R, Greve JWM, Faber KN, Moshage H, Wijmenga C, van de Sluis B, Hofker MH, Fu J. A liver-specific long noncoding RNA with a role in cell viability is elevated in human nonalcoholic steatohepatitis. Hepatology. 2017 Sep;66(3):794-808.
