NALT1

Annotated Information

Approved Symbol

NALT1

Approved Name

NALT promoted cell proliferation in vitro and in vivo. .

NOTCH1 associated lncRNA in T-cell acute lymphoblastic leukemia 1

Previous Symbols

MIR4674HG, LINC01573

Synonyms

TCONS_l2_00029132

RefSeq ID

NR_121577

Ensembl ID

ENSG00000237886

Characteristics

NALT is located in the upstream of NOTCH1, within a spacing of 10 kb..

Cellular Localization

A nuclear long noncoding RNA .

Function

NALT promoted cell proliferation in vitro and in vivo .

NALT activated the transcription of NOTCH1..

Regulation

Results provided strong evidence that the NOTCH1-dependent regulation by NALT might occurred in the stem cells in the development of T ALL .

Diseases

• pediatric T cell acute lymphoblastic leukemia

Expression

Increased expression of NALT dramatically promoted cell proliferation in cell lines via CCK8 assay and EDU stain..

Sequence

>gi|652699776|ref|NR_121577.1| Homo sapiens NOTCH1 associated lncRNA in T-cell acute lymphoblastic leukemia 1 (NALT1), long non-coding RNA

000001 AGAAGAGAGT GGCCCATTCG GTGTCCACCC GTCAGGCCAC CCAGCAGCCA GGCACGCTCA TAAGCCCGCG TTACGGATGG 000080
000081 TGCGGCCGGG TGCACAGGCC CGAGGGAAGC ACAGGCCTCG GCCTCCCAGC TCCCAACCCC TGCACCACCC ACAGCCGGGA 000160
000161 GTACCCCATG GACAGCTGTG GCCGAGGAGA AGCCAGGGAT GAGGGGGATG GGCCTCACCT CCCCACCAGC CTGGGAAGGG 000240
000241 GGTAGGCCCC TGGCAAGTAG GAGGGAAGCT GAGGCTCAGA GACATCATGA GGATGCCAGC TCAAGGCCCA GCCAGGCCTT 000320
000321 GGTCCTCAGC TGCTGTCATC CAGTAGGCTC AAGCCCAGAG GCCTCCAGGG TGTCCAGCCT CCAGGGTGCC TCCTACGCAG 000400
000401 CCTCCACGTC CCCATCCACT GCAGCCCCTG ACCATCGGGC ACACCGTGGG GCCTTCGCTG GCCGCCGGGC CTCAGGTTCT 000480
000481 GCTGCACCAA GTGATTTTTA AAGCCCCATC TGCCTTTCTC CACTTATAAA GAACTTGGGA CATTTC

Labs working on this lncRNA

• Department of Hematology and Oncology, Nanjing Children's Hospital Affiliated with Nanjing Medical University, Nanjing 210008, China.