NONHSAT119704

Please input one-sentence summary here.

Annotated Information

Name

HOXA11-AS:HOXA11 antisense RNA HOXA11AS

HOXA11-AS1, HOXA11S, HOXA-AS5, NCRNA00076

Characteristics

Bidirectional promoter with HOXA11. Multiple splice isoforms are present which share a common 3' exon (Hsieh-Li (1995), Potter (1998)), only some overlap HOXA11 (Potter (1998)). Annotated human isoform is ~1.6kb. A number of isoforms including ~1.4, ~1.9, ~2.9 and ~3.2kb transcripts have been identified in mouse (Hsieh-Li (1995)).

Function

Due to the inverse or complementary expression pattern between Hoxa11 and HOXA11as mRNA expression levels, in the developing limbs (Hsieh-Li (1995)) and adult endometrium (Chau (2002)), HOXA11as has been proposed to negatively regulate Hoxa11 mRNA levels (Chau (2002)).

Expression

More highly expressed than HOXA11 in mouse development (Hsieh-Li (1995)). Expressed in developing limbs where it showed a complementary expression pattern to HOXA11 (Hsieh-Li (1995)). Also expressed in fetal kidney (Potter (1998)), placenta, adult colon, muscle and prostate (Sessa (2007), Sasaki (2007)). Shows collinear regulation of expression like HOX PTC genes (Sasaki (2007)). Expressed in same cell types as HOXA11 in the uterus. HOXA11as was dynamically expressed in the uterus during the menstrual cycle, with a peak in the endometrial late-proliferative phase, showing a pattern inverse to HOXA11 (Chau (2002)). HOXA11as levels were down-regulated by progesterone in primary uterine stromal cells, which correlated with HOXA11 up-regulation in the same cells (Chau (2002)).

Conservation

Sequence highly conserved (Potter (1998)), found throughout mammals.

Misc

Some HOXA11as isoforms have long ORFs, however these ORFs are not conserved between human and mouse (despite high nucleotide sequence conservation) (Hsieh-Li (1995), Potter (1998)). So while HOXA11as is thought to be noncoding, a possible role for HOXA11as encoding a protein cannot be completely discounted.

Transcriptomic Nomeclature

Please input transcriptomic nomeclature information here.

Regulation

Please input regulation information here.

Allelic Information and Variation

Please input allelic information and variation information here.

Evolution

Please input evolution information here.

You can also add sub-section(s) at will.

Labs working on this lncRNA

Please input related labs here.

References

Annotation originally sourced from lncRNAdb.

Basic Information

Transcript ID	NONHSAT119704
Source	NONCODE4.0
Same with	,
Classification	intergenic
Length	1628 nt
Genomic location	chr7+:27225027..27228912
Exon number	2
Exons	27225027..27225882,27228220..27228912
Genome context
Sequence	000001 GCCACCTCAG GGGAAGCAAC AGATCGTCAC TCGGTGTTCT CACCGAAAGC ACGTAATCGC CGGTGTAACT CATGTTGGCT 000080 000081 GGGGGGCCTC CCGGCGCGCG CGGAGAGGCT GGGGTGCGCC CCCATGCAGC ATGCTTGTGC TCAATTGCAG GGTCCTCGTT 000160 000161 CTCGAGTGTG CAGAGGGCGG TGAGAGCTCA ACTCTCGTCC CCACCTCCCA CCCGCAGCTC CCCGGGTGGG TGAGGGATGC 000240 000241 CCTGGACTGG GGATAGCCAG GTGGGAGTCC GTCGCTGTGT GGCCTGTGGT CTCGGAGTCT GTTCTCCTGG AGTCTCGCAT 000320 000321 TTGCACCCCC TTCTTCGCAG TCCCCCTCCC ATAGACTTGC TCTGGGAAGC GCCTCTGCCT CCGACCCTAG CCGGAACCCC 000400 000401 TTCGGGGCCA GAGTTTGAAG CCGTGGATGT GCCTGCCTGG TGGCTTGTCC GATTTGCACG GTGACTTGAT TACACTCTCT 000480 000481 CATTCATGGT CACTTCCGAA GCGCTTTAGT GCCTTCCGTC CCTAAACCGC CAACAGCCAG AACGGCTTCT CCCCGCGGTT 000560 000561 TGTCACTGAT CCGCAGGGCC CGGAAGGGCC TTCGTCTTAC CCGGGATCCA CCTCTCCCCT CATCTTCCCT GCCTACCTCT 000640 000641 TCATCCCACC TTCTGTCCTT GGAGAAACTC CCTCCTCCTC GCTGCCTGCC GGGCTTCGGA GTGACTCGGC AGAGACAGAG 000720 000721 GCACAGGGGC TGCCCTGCTG CTCACCGGTC CACCCATCTG CCTGGTCTTC TGGAGCTGAG GACTCGGGAA ACCATGCAAT 000800 000801 TGAGGCAAGC CTTGGGCTGC TTTAGAGGCG CTGACATCCG AGGAGACTTC TCCTGGGAGG TCCAACAGCC GAGCTTAGCC 000880 000881 CACCGGGCTC TGGGAAAGAC CCGACTGAGG CTAAAGCCGC CCCGGAAGGC CAAGTCCGAG TTCCATTTCT TGAAGAGGCC 000960 000961 GGCGCGCGTA AGGCTGTGAC ATTGGCCCTG GCGACTGGCT TCCCAGGAGC TGTTCTTTCT CAGGAGCTCC ACAGCGCGGG 001040 001041 CCATCTCCAG AAAACTGTCT TCAGAGTGTA TTTCCTTTTA TCGTCAACCC AGAGCCCCAC CGCGGCTAAT GCAAGAGGCC 001120 001121 AAAAAATGTT TGGAGGAAGA AAAACAAAGG CAGGAAGTGG CGGCGGCCTG ACGGTGCGTG TGTGTCTGCA GAGAAGGGAG 001200 001201 GGAGCCGGCT CAGTCTCTTC TTGTTTTTCC AAACTTCAAG GTCCAGGCAG CCCTCTGCAG GGCCGGGCCC CATTGCTCCC 001280 001281 CGCGCGGCAT TGGAGGTGGC CGCCCGGAGA GGAGAAGGCC AACGCCTGCG CCAGGCTTGT CAGGCGGAAA CGGCTAACAA 001360 001361 GGAGATTTGG TCAGCAAAAC AGACCCAGCC TTTCCGAGGC TTCGTCTGAC TTGGCCCGAA AGGTTGGGGA GGGGGGGCTT 001440 001441 GCGCAGAGCC TCAGGGACCC TCCTCTCTGG GGACTACCAT CCCTGAGCCT TACGCTTCTT TCCACAGCCT TTGCAGGCGG 001520 001521 AATATCGGAA TAAAGTGGGT CCAGGCGCCA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA 001600 001601 AAAAAAAAAA AAAAAAAAAA AAAAAAAA

[back to top]