NPPA-AS1

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Annotated Information

Approved Symbol

NPPA-AS1: NPPA antisense RNA 1

NPPA-AS forms RNA duplexes with NPPA [1].
Splicing isoforms and expression pattern of NPPA and NPPA-AS [1].

Previous Symbols

NPPAAS, NPPA-AS

Chromosome

1p36.21

RefSeq ID

NR_037806

Ensembl ID

ENSG00000242349

Characteristics

NPPA-AS is the antisense partner of NPPA, and NPPA-AS overlaps with the intron-exon boundaries of NPPA gene in both mouse and human [1]. The predicted ORF (Open Reading Frame) within NPPA-AS is about 121 amino acids in length [1].

Function

NPPA-AS forms RNA duplexes with NPPA in vivo and modulates NPPA expression at post-transcriptional level [1]. A specific NPPA-AS isoform is capable of down-regulating the intron-retained NPPA mRNA variant [1].

Expression

NPPA-AS is expressed in many human tissues as a collection of alternatively spliced isoforms, while in mouse the expression is observed only in brain [1].

Evolution

Neither the primary structure nor the expression pattern of NPPA-AS is conserved between mouse and human [1].

Disease

Cardiovascular disease [1]

Sequence

>gi|323276587|ref|NR_037806.1| Homo sapiens NPPA antisense RNA 1 (NPPA-AS1), antisense RNA

000001 ATTCCCAGTC ACCCACTCAC TCAGAAAGCC GGGAGTCATC GGACACCTTG CTGGTCAGAG GTCCTGGGGG TGGTTTTGAA 000080
000081 CCATCAGAGC TTGGACTTTT CTGACTTCCC CAGCAAGGAT CTTCCCACTT CCTGCTCCCT GTGTTCCCAC CCTCCAGTGT 000160
000161 TGGCACAGGC CCACCCCTGG CTCCACCAGA GCCAGAAGCA GAGGTAGAAT CAGGCGGGCC CCGGGCTGCA CTCCGAGCAG 000240
000241 TGTTCCTGGC CATCTTTGCT ACTTTCCTAG AGAACCCGGC TGTTGCCTTA AATGTGTGAG AGGGACTTGG CCAAGGCAAA 000320
000321 AGCTGGGGAG ATGCCAGTGA CAACATACAG TTCATGACTA GGTTTAGGAA TTGGGCACTG AGAAAATTCT CAATATTTCA 000400
000401 GAGAGTCCTT CCCTTATTTG GGACTCTTAA CACGGTATCC TCGCTAGTTG GTTTTAAGGG AAACACTCTG CTCCTGGGTG 000480
000481 TGAGCAGAGG CTCTGGTCTT GCCCTGTGGT TTGACTCTCC TTAGAACCAC CGCCCACCAG AAACATAAAG GATTAAAATC 000560
000561 ACACTAATAA CCCCTGGATG GTCAATCTGA TAATAGGATC AGATTTACGT CTACCCTAAT TCTTAACATT GCAGCTTTCT 000640
000641 CTCCATCTGC AGATTATTCC CAGTCTCCCA GTAACACGTT TCTACCCAGA TCCTTTTTCA TTTCCTTAAG TTTTGATCTC 000720
000721 CGTCTTCCTG ATGAAGCAGG CAGAGCTCAG AGGATCTTGG CATCACCCAC CAAAGTTAGC TGAAAGCAGG GCACTCCTGG 000800
000801 ATAAAGCAGC TTCACTCAAC TCTGGGGAAT GCTACCATTT TTTTTCCAAA GTAGAAAGGA AGCACTTCTG AGCCAGTGAC 000880
000881 CACTGAAAGA TGAACACTCT TCCTGATCCT CTCCTCTAGA ATTCATCTCC TCCTGCTAGC AGCCGCGTCC TGGAGGAGCA 000960
000961 GCGGATGGGG AATCCATTCT GTTTCTTCCT GGTGTTTAGG AAGTTGCCCC ACACACAGAT TGCCCCGATG TCCAACCAGA 001040
001041 AGAAGTGAAA CTGCTGCTGG GTCTGGAGAG GTGAAGACCC GTGGCCAGCT TCTGTTGTTG CCATCGGCCA TTGCTTTTTG 001120
001121 TTCGCTTGCT TTTGGTTTTG CAAGAAGAGC GGCCTCTGTC TCTGATCTGC TTCAAATCAT CATTCCATCA GTGACAGAAG 001200
001201 TGGCTGTTCC ATCAGTGGTC GCAGCCAGTT CAGCTCCTGC ATCCATCCCC AAGTGTTCTG AGTGGAATTT GAGGCCTCCC 001280
001281 CAACCACCTA CCAAAAAAGG AGGGTGAAAT GAAAGGAAGA AGAAAAACTC AGCATTCTTT CCTCTGACAA AGAGTAAAAC 001360
001361 GACAAGGAAT ATCGGCCTGA ATTCTCTTCC CAAGAAGAAA GAAAGCACAC CAACGCAGGC ATTTGTCTTC TGTCCATGGT 001440
001441 GCTGAAGTTT ATTCACTTTC AAACCACTTT CAGTAACAGC AAATTCTTTA GAAAAGGAAA ATACAGGGAA AGGGATAAAC 001520
001521 CTCACTGACT TGGAGGAAAT CAAGAGGAGT GAGCACAGCA TCAGAAAGCC CCCTGGCCCC AGACTGCACC CGCTTTCCTG 001600
001601 GCCCTACCTT GAAATCCATC AGGTCTGCGT TGGACACGGC ATTGTACATG GGATTAGCTC TG

Labs working on this lncRNA

  • Institute of Molecular and Cell Biology, University of Tartu, 51010 Tartu, Estonia [1].

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 Annilo, T., Kepp, K. and Laan, M. (2009) Natural antisense transcript of natriuretic peptide precursor A (NPPA): structural organization and modulation of NPPA expression. BMC Mol Biol, 10, 81.
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