PAWR
Contents
Annotation
Name
PAWR
Alias
NA
Disease
Disease: acute lymphoblastic leukemia (PMID:23906015)
Dysfunction type: NA
Description: T-ALL-R-LncR1 was not observed in human normal tissues.An obvious expression was observed in some tumor tissues. T-ALL-R-LncR1 was markedly expressed in neoplastic T lymphocytes of 11 cases out of 21 children with T-ALL, indicating that T-ALL-R-LncR1 might be associated with T-ALL. T-ALL-R-LncR1 knockdown predisposed Jurkat cells to undergo pro-apoptotic factor Par-4-induced apoptosis.T-ALL-R-LncR1 knockdown facilitated the formation of a Par-4/THAP1 protein complex, resulting in the activation of caspase-3 and an increase of pro-apoptotic Smac protein in T-ALL cells
Function
Function Mechanism: NA (PMID:23906015)
Biological Process: pathogenic process
Description: therapy target
