PELATON
PELATON are a new class of multi-functional molecules that can be used to study human physiological diseases.[1]
Contents
Annotated Information
Name
Approved symbol:PELATON
Approved name:plaque enriched lncRNA in atherosclerotic and inflammatory bowel macrophage regulation
HGNC ID:50328
Previous name:long intergenic non-protein coding RNA 1272|small integral membrane protein 25
Alias symbol:GCRL1
RefSeq ID:NM_001278655
Prev_symbol:LINC01272|SMIM25
Characteristics
PELATON were found in unstable plaques.[2]
Function
PELATON could regulate gastric cell proliferation and metastasis, both in vitro and in vivo.[1] PELATON knockdown of PELATON significantly reduced phagocytosis, lipid uptake and reactive oxygen species production in high-content analysis, with a significant reduction in phagocytosis independently validated.[2]
Regulation
PELATON promoted the cell proliferation and metastasis by sponging miR-885-3p and hence, positively regulating CDK4 in GC cells.[1] PELATON as a new target for atherosclerosis prevention to prevent cardiovascular disease.[2]
Expression
Upregulation of PELATON in gastric cancer tissues and cell lines,so in breast cancer cell lines (MCF7 and T47D).[1] PELATON is a nuclear expressed, monocyte- and macrophage-specific lncRNA, upregulated in unstable atherosclerotic plaque.[2]
Diseases
Gastric cancer(GC)[1] Cardiovascular disease[2]
Labs working on this lncRNA
- Center for Tumor Molecular Biology, Institute for Translational Medicine, Qingdao University, Qingdao, 266021, China.[1]
- Key Lab for Immunology in Universities of Shandong Province, School of Clinical Medicine, Weifang Medical University, Weifang, 261053, China.[1]
- Department of Anesthesiology, PLA Army General Hospital, Beijing, 100700, China.[1]
- Department of Gastroenterology, PLA Army General Hospital, Beijing, 100700, China.[1]
- Department of Pathology, Affiliated Hospital of Weifang Medical University, Weifang, 261041, China.[1]
- Center for Tumor Molecular Biology, Institute for Translational Medicine, Qingdao University, Qingdao, 266021, China. peifli@qdu.edu.cn.[1]
- From the Centre for Cardiovascular Science, University of Edinburgh, United Kingdom (J.H., J.P.S., A.D.M., J.R., M.B., J.K., K.L.C., R.B., D.E.N., J.C.S., A.H.B.).[2]
- Maastricht University Medical Center, Maastricht, the Netherlands (M.A.C.F., L.T., E.A.L.B., J.C.S., A.H.B.).[2]
References
- ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 Lin Z, Zhou Z, Guo H, He Y, Pang X, Zhang X, Liu Y, Ao X, Li P, Wang J. Long noncoding RNA gastric cancer-related lncRNA1 mediates gastric malignancy through miRNA-885-3p and cyclin-dependent kinase 4. Cell Death Dis. 2018 May 22;9(6):607. doi: 10.1038/s41419-018-0643-5.
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 Hung J, Scanlon JP, Mahmoud AD, Rodor J, Ballantyne M, Fontaine MAC, Temmerman L, Kaczynski J, Connor KL, Bhushan R, Biessen EAL, Newby DE, Sluimer JC, Baker AH. Novel Plaque Enriched Long Noncoding RNA in Atherosclerotic Macrophage Regulation (PELATON). Arterioscler Thromb Vasc Biol. 2020 Mar;40(3):697-713. doi: 10.1161/ATVBAHA.119.313430. Epub 2019 Dec 12.
