RN7SL3
RN7SL3,transcribed by RNA polymerase III, influences transcription activity.[1][2]
Contents
Annotated Information
Name
Approved symbol: RN7SL3
Approved name: RNA component of signal recognition particle 7SL3
HGNC ID:23135
Previous symbols: RN7SL631P
Previous names: RNA, 7SL, cytoplasmic 631, pseudogene; RNA, 7SL, cytoplasmic 3
Alias symbols: 7L30.2; RNSRP3
RefSeq ID: NG_011406
Characteristics
The RN7SL3 locus differs by several single base changes from the known human 7SL RNA sequences and does not appear to be expressed at a detectable level in HeLa cells.[1] Comparison of the upstream regions revealed the presence of two conserved elements in the two human RN7SL3 genes, an ATF/CRE binding site at -43 to -50 and a TATA-like box centered around position -25.[2]
Function
Two sequence motifs can be identified in RN7SL3 at positions 10-19 and 50-60, respectively, downstream of the transcription start site that resemble putative A and B boxes. Single and multiple nucleotide substitutions in these regions also influenced transcription activity to a great extent.[2]
Labs working on this lncRNA
- Institut für Biochemie, Universität Würzburg, Biozentrum, Am Hubland, D-97074 Würzburg, Germany.[2]
- Department of Molecular Biophysics and Biochemistry, Yale University,P.O. Box 3333, New Haven, CT 06510, USA.[1]
References
- ↑ 1.0 1.1 1.2 Ullu E, Weiner AM. Human genes and pseudogenes for the 7SL RNA component of signal recognition particle. EMBO J. 1984 Dec 20;3(13):3303-10.
- ↑ 2.0 2.1 2.2 2.3 Englert M, Felis M, Junker V, Beier H. Novel upstream and intragenic control elements for the RNA polymerase III-dependent transcription of human 7SL RNA genes. Biochimie. 2004 Dec;86(12):867-74. doi: 10.1016/j.biochi.2004.10.012.
Sequence
>NR_145670.1 Homo sapiens RNA component of signal recognition particle 7SL3 (RN7SL3), small cytoplasmic RNA
000081 GGGCTGTAGT GCGCTATGCC GATCGGGTGT CCGCACTGAG TTCGGCATCA ATATGGTGAC CTCCCGGGAG CGGGGGACCA 000160
000161 CCAGGTTGCC TAAGGAGGGG TGAACCGGCC CAGGTCGGAA ACGGAGCAGG TCAAAACTCC CGTGCTGATC AGTAGTGGGA 000240
000241 TTGCGCCTGT GAATAGCCAC TGCACTCCAG CCTGGGCAAC ATAGTGAGAC CCTGCCTCT
