SIX3-AS1

Annotated Information

Name

SIX3-AS1:SIX3 antisense RNA 1

SIX3OS

Characteristics

SIX3OS has following features:(1) undergoes extensive alternative splicing, with the number of splice isoforms ranging from 1(RaxOS) to 11(Six3OS), (2)shows sequence complementarity, either in human or in mouse, to the mature sense mRNA or to their primary unprocessed transcripts, (3) the degree of sequence similarity between murine and human NATs is very low, with the exception of Six6OS (∼79% identity), and is in general restricted to segments (exons) not exceeding 150 bp in length for each NAT, (4) do not show any open reading frames (ORF) and may therefore represent non-coding RNA transcripts.

Expression

NATs associated with eye transcription factors are predominantly expressed in retina both in mouse (A) and in human.

RT–PCR experiments carry out on a panel of 10 adult human RNAs demonstrate that the SIX3OS is predominantly expressed in retina with a lower level of expression in the brain or colon in human.

Sequence

>NR_103785.1 Homo sapiens SIX3 antisense RNA 1 (SIX3-AS1), transcript variant 1, long non-coding RNA

000001 TTTTTTTTAT CTTTGCAACT CTTAATCTCG CTACCTCCCC CTCCTCTCTT CTCTCTTCTC CCTCTCTCTC CTCTTTTCTC 000080
000081 TACCGCTGTC TCTGAGACTT CTTCTTCCCT TTTTCCTAAA GAAGTTGATC CAGAAATTCG AAAAGCCCTG GGCAGAGTTG 000160
000161 TTGAATGGGA TGTGCAATTA GAGAGGGGAT TTTGTTGGGA GGCAAGAGGG TCCCCCAGGC TCCACATAGT CCAGGTCGGC 000240
000241 AGGCAAGGAA AGACGGCTGA CCAGCCCAGC GGGCGCGGTT TGCACATGGT TTGCACGTCG GGCCGCCTCT TTCTGCCTAT 000320
000321 AATTCAGCTG CCTCTCTGAG GAGTGGTGGA GGAGCTGCGG GAGCCGAGAA GCCCAAGAGC CCTCTGGACC CAGAAAAGTC 000400
000401 CTACAGATGC CCACTCCTCA CCACACAACA GAAGGAGCTC TGGTCCTGCC TGCCAGCCCC AGAGGGCACT CAAACTTTGG 000480
000481 AGGCCAGCCA CCCGGATGAA GTGAATAAGG CCTGAAAATT GCTTGTTTGC TCGTATTGTA AAATAATAAT AATTACCATT 000560
000561 ATTATTTTTA AACTGTCTAA TTTCTCTAGG GAAAGTAACA TCGAAAGCCT AAAACAGACG CCAAAAGGCC CATAGAACAC 000640
000641 AGAGGGCCCT CTCTGCCTCT GGCCACCACA GCCCCTAGGC CAGGCATGGG TATTTATTCT TAGGTATGTT GCTTTTAAGA 000720
000721 AGCTGTAATC AGCATCTTGA GCCGGGCCTC CCTTTGTGAG GCTTCTGTAA CTATGGAAGT GTGATTTACG CAGATTTGTC 000800
000801 GGGGTCAGAG ACGTCTTTCC CTGAGCACTG TGTATATTTA GACAGGACTC GGTTTGGTGT TAAAAAGTGT ATATGTTGAA 000880
000881 TGGATTCACA CACAGTAGCC AACAATGACC ACATTGTCGG CCCGTGTACA ACGCGTATTG AAACGCAGCG CCCAGACTTC 000960
000961 AACTAATCTG CCCTCAATAA AGCTGAAATA ATTATCCTAA

Labs working on this lncRNA

• Telethon Institute of Genetics and Medicine, Via Pietro Castellino 111, 80131 Naples, Italy.