SKAP1-AS1

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Annotated Information

Name

SKAP1-AS1:SKAP1 antisense RNA 1

RP11-456D7.1[1]

Function

According to the GO and pathway enrichment analyses, the target genes of RP11-456D7.1 are mainly enriched in the molecular function. In addition, RP11-456D7.1 also positively regulates CCL21, a high-affinity functional ligand for chemokine receptor 7 (CCR7) that is expressed on T and B lymphocytes and plays a key role in the inflammatory response.[1]

Expression

The expression of RP11-456D7.1 is upregulated in the mild and severe pneumonia groups compared with controled groups.[1]

Diseases

Pneumonia[1]

Labs working on this lncRNA

  • Department of Hematology, Chinese PLA General Hospital, Beijing, China (mainland).

References

  1. 1.0 1.1 1.2 1.3 Huang S, Feng C, Chen L, Huang Z, Zhou X, Li B, Wang LL, Chen W, Lv FQ, Li TS. Identification of Potential Key Long Non-Coding RNAs and Target Genes Associated with Pneumonia Using Long Non-Coding RNA Sequencing (lncRNA-Seq): A Preliminary Study. Med Sci Monit. 2016 Sep 24;22:3394-3408.