SNHG17
SNHG17 has a role in colorectal cancer (CRC) progression, depicting SNHG17 as a potential therapeutic target for CRC patients.
Contents
Annotated Information
Name
SNHG17: small nucleolar RNA host gene 17 (HGNC nomenclature).
Characteristics
SNHG17 has a chromosomal location: 20q11.23 (HGNC nomenclature).
Function
SNHG17 exerts oncogenic functions partly through regulating P57 expression. These findings represent the first reporting of the roles and mechanisms associated with SNHG17 in CRC progression, making SNHG17 as a potential therapeutic target for CRC patients [1].
Regulation
lncRNA SNHG17 epigenetically suppresses P57 by binding to enhancer of zeste homolog 2 (a key component of polycomb repressive complex 2) in CRC cells, and quantitative real-time polymerase chain reaction assays demonstrates that SNHG17 expression levels were inversely correlated with those of P57 in CRC tissues [1].
Diseases
- Colorectal cancer (CRC) [1]
Expression
SNHG17 is upregulated in CRC tissues, and that its overexpression is significantly correlated with tumor size, TNM stage, and lymph node metastasis in CRC patients [1].
| Experiment | Forward primer | Reverse primer |
|---|---|---|
| qRT-PCR | 5'-TGCTTGTAAGGCAGGGTCTC- 3' | 5'-ACAGCCACTGAAAGCATGTG- 3'[1] |
Labs working on this lncRNA
- The Second Clinical Medical College of Nanjing Medical University, Nanjing, 210000, Jiangsu, People's Republic of China. [1]
References
Sequence
>gi|388796|ref|NR_015366.5| Homo sapiens small nucleolar RNA host gene 17 (SNHG17), long non-coding RNA
000081 ATCGCACGCC ACCGCACCCC ATCTCTCGAA ATCTGCAGAC ATCTTGATTT TTCCCACGCT GTCTGTCAGG TCTCCGCCGC 000160
000161 CACTCGACGC CAGGGCGCCG GGCCTTGTGG GCTGTGCTGC ACCTCGGACG GCTTCGCACC AGCCAGCGCC CTCTCTCTCC 000240
000241 TGCAGCACTC TGATCTGCAC CCCCTGAGGG GCTTCCACTG TCCGCGGGGT GAGAATGCCC CTGGGAGTGT CACATGACTG 000320
000321 CCGCCCCATG TGTGTGAGAG GCGTCCTCTG GGAGAGCATG GATCCTGAGG TCCCAGGATT GTCAGCTGAC CTCTGTCCTG 000400
000401 TGTGCCCAGT GGCCCCAGGT GACGTGTCTT CAAGAAGAGG CTGAGCTGCG GTGCTTGTAA GGCAGGGTCT CATTCTGTCA 000480
000481 CCCAGGCTGG AGTGCAGTGG TGCAATGATG GCTCACTGCA GCCTCGACCT GGGCTCAAGT GATCCTCCAC CTCAGCTTCC 000560
000561 TGAGTAGCTG GGACCACAGA GTCATGTGCT GTTCCTGGGG CTTGGATGAT GTAGGGGAAG CAAGGTGAAA GTGGTATCCC 000640
000641 GTGGTTCCAC GTTCTGTCCT GCTGTGGGGC TGTCCCTCAC ATGCTTTCAG TGGCTGTTGC AGAGGAAGAG CCTCCGGAAA 000720
000721 TCTGCGTGGG TCTCAGCCTT AGATCCAAGG ACAGTCCAAG GAAGTCCTAA GACCATGGAG TTGGTGATCT GGGATCTGGG 000800
000801 TTTGCTGATA TTTCTCACCG TGAATCTCTT GGTGGTGTTT GTGGGCACGA GAGGGGCAGA GAATGGAGAG TGAGGCTACC 000880
000881 ACATGAAGCG TCACCAGAGC TGCTCCCTGC TGCCTGCTCA GAGCACCCCG GATCCACTGT TCAATCTGCA CAAGATTCGG 000960
000961 GGTCCAGACA TGGGAGACTT CAGCTGCCTC AGAGGACCGT GGACAGGGAA GGCCAGCCTC GCATCCCTCT GTCCATGCCT 001040
001041 GGAATGACTT TAATAACCAA GAGTTTTATT TTTGAATTTG TAGCTGTCGT TCACTTTTTA CCCACCCATT CAATAAACCT 001120
001121 TACAGAATTG CTCCA
