THUMPD3-AS1

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Neuron death is stimulated by THUMPD3-AS1 in stroke via promoting PTEN expression.

Annotated Information

Name

Approved symbol:THUMPD3-AS1

Approved name:THUMPD3 antisense RNA 1

HGNC ID:44478

Previous name:SETD5 antisense RNA 1

Previous symbol:SETD5-AS1

RefSeq ID:NR_027007

Characteristics

THUMPD3-AS1 has a chromosomal location of 3p25.3 (HGNC data).

Function

THUMPD3-AS1 is highly expressed in the ischemia-reperfusion injury model. THUMPD3-AS1 participates in the development of ischemic stroke by activating PTEN and inhibiting PI3K/AKT pathway [1]. PI3K/AKT pathway participates in the regulation of cell apoptosis, survival and proliferation via targeting downstream genes, including Bad, caspase and NF-κB [1].

Diseases

Expression

THUMPD3-AS1 is highly expressed in the ischemia-reperfusion injury model [1].

Experiment Forward primer Reverse primer
qRT-PCR 5'-GCTTTTCTCGCTATGCTGCC- 3' 5'-AGTTTGCCATTTGGGTGGTC- 3'[1]

Labs working on this lncRNA

  • Department of Neurology, Qianfoshan Hospital Affiliated to Shandong University, Jinan, China. [1]

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Miao SY, Miao SM, Cui RT, Yu AL, Miao ZJ. SETD5-AS1 stimulates neuron death in stroke via promoting PTEN expression. European review for medical and pharmacological sciences. 2018, 22(18):6035-41.

Sequence

>gi|440944|ref|NR_027007.3| Homo sapiens THUMPD3 antisense RNA 1 (THUMPD3-AS1), long non-coding RNA

000001 GGAAGCCGCC GGGGCCGCCT AGAGAAGAGG CTGTGCTTCG GCGCTCCGGC TCCTCAGAGA GCCTCGGCTA GGTGTGGAAA 000080
000081 CAGGAAGAGA ACTAGAACTG GAAGTAAAGC ATTGAAGATG TGACTGAATT GCTGCAATCT CATGATCAAA TTTGAATGGA 000160
000161 TGAGGAGTTG CTTTTTAGGG ATGAGCAAAG AAAGTGGTTT CTCGAGATGG AATCTACTGG TTGCTCCTTG AGGGCAGGAC 000240
000241 AGTTCTTATG GCTTTATCCG TTGCGTAAGC ACAGAGAGGT CTGCGAGGTC AAAACTATTG TCATGATAGC AAGATGCCTG 000320
000321 TCTTTTTCAT TTATTCTCAC GGTGTGCAGA GGCTACATGA TGTGTGATGA CATCCTCATT GATGTTAATG AATGGTGCTA 000400
000401 TACTTGAATT TTCTAAGGTG TCATTAGGTA GGTTTAGGTA TGCATACTTG TTTTTAGAAA TTATTTTTTT CCTTTTTCCC 000480
000481 ATTTTTAGAA ATCAACTCAT TTTTTAGGTT ATGCCTTCAG TAATCTTTGC AACCTCAATA TTGTGTAATG GTTACTTTAA 000560
000561 AATACTGTAG TTTTCTTTGT GCCTAAGTAT AAACATAAGT ACATTTTGTT GTTTTGTTTG CAATAGTGGT TTAAATATTT 000640
000641 TCCCAAAATA TCCAAATTTA AAAATTCTAC AACTTTAGAA TTTAATAAAT TTATTCTAAA ATATTTATAT ATTTTTTCAT 000720
000721 TTAAGAATGG ATCGGCTTAA AAAGACTGCT TCTCATTTAC TTACTGGCTA TACCATCTGT ATACTAATAA AAAACAAGAT 000800
000801 TTGATTTGGA AGGACTGACT CAAACTAACG AAAATATGAA ACCTGTCTTT CTGCTTTGGA GATATTTACC TAATCATGTT 000880
000881 CTGCAGTAGA ATAATTTAGT TCTTTTGTCT TTTTTTGGAG ATGAGGTCTT GCTGTGTTGC CCAGGCTATT CACAGCTGCC 000960
000961 ATCATAGTGA ACTACAGCCT GAAACTCCTG GGTTCAAGAG ATCCTTCTGC CTCAGCCTCC TGAGTAGCTG GAACTATAGG 001040
001041 CATGCGCCAC CAAGCCTGGG CTTTTAAAAA AATTTTAAAA AGAATTTTGA GACAGGATCT TGCCATGTTG CTCAGGCTAG 001120
001121 TCTTCAACTC CTAGCCCTGA GTGATCTTGC TTTGGGCCTC TCAAAATGTT GAGTTAATAG GCGTGAGCCA CCATACCCAG 001200
001201 CCAAAAATTT TTTTAGAGAT GGGAATGGAA TGATCTTGAA TAGTGTTGGT GCCACCTATG TTGTGGCATC ATTTTGAAAC 001280
001281 CAATCATTCA GAGTGCTTTT TTTGGTAAGG CATTATTTTT TAATGCAGGT ATGCCACTAC TGGGAAAAAA AAAAAAACAG 001360
001361 GTTTTAAAGC TAGAAATGAA AAGCTACTTA AGTATCTTAA AGGATAAGTT ACTTTATTAT ACACTAGAAA CATACACAAT 001440
001441 AGCTGAAAAA CTTAAAAAAT CTCACACTGC TGAATGTCTC TGCTGGCTGA AGTGTAAGTA AAAGATCATA GTAGTGCCGC 001520
001521 TGTTGAGTGA TAAAGCAACT TGTCATTAAA GATGTGTGTG CAGACATGGA TTCTGAGTTA ATATCTCATC TGTAGAAGTA 001600
001601 TATATTTGTC CCTTGCTTTG GGATTGGTTT CTGGACAGCA CTCCCCCACC CTTGCTGGCC ATTTGCCAAG GACACCAAAA 001680
001681 CCCAAGGATG TTGAATTCCC TTTTATAAAA TGGCGCTGTA TCTGCATACA ACTTACACAC ATCCTCCCAT ATACTTTAAA 001760
001761 TCATTTCCAG ATTTCTTATA CTTCATACAA TGTGAATGCT ATATAAATAG TTGTTACATT GTGTACTTAT ATTTGTACTA 001840
001841 TTGTATTAAA TATTCTCAAA TATTTTCAAG CAAAAAA
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