UICLM
UICLM induced its biological effects by regulating ZEB2, as the oncogenesis facilitated by UICLM was inhibited by ZEB2 depletion[1]
Contents
Annotated Information
Name
Approved symbol：UICLM
Approved name：up-regulated in colorectal cancer liver metastasis
HGNC ID：54869
Alias symbol：CROCC2-AS1
RefSeq ID:NR_033841
Characteristics
location:2q37.3 UICLM has no protein coding capability.[1]
Function
Ectopic expression of UICLM promotes CRC cell proliferation.[1]
Regulation
UICLM induced its biological effects by regulating ZEB2, as the oncogenesis facilitated by UICLM is inhibited by ZEB2 depletion[1]
Expression
UICLM (up-regulated in colorectal cancer liver metastasis) is significantly up-regulated in cases of CRC with liver metastasis.[1] UICLM expression is higher in CRC tissues than in normal tissues, and UICLM expression is associated with poor patient survival.[1]
Disease
Colorectal cancer (CRC)[1]
Labs working on this lncRNA=
- State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, PR China.[1]
- Department of Oncology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, PR China.[1]
- Department of Molecular and Cellular Oncology, the University of Texas MDAnderson Cancer Center, Houston, TX77030, USA. [1]
References
- ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 Chen DL, Lu YX, Zhang JX, Wei XL, Wang F, Zeng ZL, Pan ZZ, Yuan YF, Wang FH, Pelicano H, Chiao PJ, Huang P, Xie D, Li YH, Ju HQ, Xu RH. Long non-coding RNA UICLM promotes colorectal cancer liver metastasis by acting as a ceRNA for microRNA-215 to regulate ZEB2 expression. Theranostics. 2017 Oct 17;7(19):4836-4849. doi: 10.7150/thno.20942. PMID: 29187907; PMCID: PMC5706103.
