UNC5B-AS1
UNC5B-AS1 plays an oncogenic role in breast cancer cells through activation of the AKT/mTOR signaling pathway, being a novel RNA oncogene. [1][2]
Contents
Annotated Information
Name
Approved symbol:UNC5B-AS1
Approved name:UNC5B antisense RNA 1
HGNC ID：45096
Alias symbol：UASR1
RefSeq ID:NR_038453
LncBook ID：HSALNG0078695 pubmed_id 30805847|31205563
Characteristics
location:10q22.1[1] UNC5B-AS1 is 647bp in length consisting of two exons. This lncRNA is an antisense of intron 1 of unc-5 netrin receptor B (UNC5B) gene.[2]
Function
The lncRNA UNC5B-AS1 promotes proliferation, migration, and invasion in papillary thyroid cancer cell lines.[1] UNC5B-AS1, plays an important role in tumourigenesis and metastasis of PTC.[1]
Regulation
UNC5B-AS1 activated AKT and AKT-mediated mTOR signaling pathway to stimulate cell proliferation and growth.[2]
Expression
Upregulated UNC5B-AS1 correlated with lymph node metastasis (P < 0.001), tumor size (P = 0.002) and histological type (P = 0.013).[1] Ectopic expression of UNC5B-AS1 promoted proliferation and clonogenic growth of breast cancer cells MCF7 and MDA-MB-231.[2]
Disease
Papillary thyroid cancer[1] Breast cancer[2]
Labs working on this lncRNA=
- Department of Thyroid and Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang, People's Republic of China.[1]
- Department of Cardiac Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People's Republic of China. [1]
- Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University. 283 Tongzipo Road, Changsha 410013, Hunan, China.[2]
- College of Bioscience and Biotechnology, Hunan Agricultural University, Furong District, Changsha 410128, China.[2]
- Department of Medical Microbiology, Immunology & Cell Biology, Southern Illinois University School of Medicine. 913 N. Rutledge Street, Springfield, IL 62794.[2]
- Department of Pharmaceutical Engineering, School of Chemical Engineering, Xiangtan University, Xiangtan, 411105, China.[1]
- Biotechnology Department, College of Science, Baghdad University, Baghdad, Iraq, 10071.[2]
- Laboratory of Hepatobiliary and Pancreatic Surgery, Affiliated Hospital of Guilin Medical University, 15 Lequn Road, Guilin 541001, Guangxi, China.[2]
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 Wang Y, Bhandari A, Niu J, Yang F, Xia E, Yao Z, Jin Y, Zheng Z, Lv S, Wang O. The lncRNA UNC5B-AS1 promotes proliferation, migration, and invasion in papillary thyroid cancer cell lines. Hum Cell. 2019 Jul;32(3):334-342. doi: 10.1007/s13577-019-00242-8. Epub 2019 Feb 25. PMID: 30805847.
- ↑ 2.00 2.01 2.02 2.03 2.04 2.05 2.06 2.07 2.08 2.09 2.10 Cao Z, Wu P, Su M, Ling H, Khoshaba R, Huang C, Gao H, Zhao Y, Chen J, Liao Q, Cao D, Jin J, Zhang X. Long non-coding RNA UASR1 promotes proliferation and migration of breast cancer cells through the AKT/mTOR pathway. J Cancer. 2019 May 12;10(9):2025-2034. doi: 10.7150/jca.29457. PMID: 31205563; PMCID: PMC6548165.
