VPS13B-DT
VPS13B-DT , a oncogenic lncRNA in IL-11/STAT3 signaling, constitute a potential target for gastric cancer intervention.[1]
Contents
Annotated Information
Name
Approved symbol：VPS13B-DT
Approved name：VPS13B divergent transcript
HGNC ID：54375
Alias symbol：OLC8
RefSeq ID：XR_928448
Characteristics
location:8q22.2[1]
Function
VPS13B-DT facilitates GC progression.[1]
VPS13B-DT facilitate migration and viability of MKN1 and AGS cells. In vivo experiments also confirme an oncogenic role for VPS13B-DT.[1]
Regulation
VPS13B-DT associate with IL-11 transcripts. The VPS13B-DT-IL-11 binding greatly impaired the degradation of IL-11 mRNAs.Enhanced expression of IL-11 could increase STAT3 activation to favor gastric cancer development. [1]
Expression
VPS13B-DT is significantly overexpressed in gastric cancer specimens and cell lines.[1]
Disease
Gastric cancer [1]
Labs working on this lncRNA=
- Department of Gastroenterology, Panyu Central Hospital, Guangzhou, Guangdong, China.[1]
