ZEBTR
ZEBTR, a lncRNA, promotes the proliferation and invasion of pancreatic cancer cells.
Contents
Annotated Information
Name
Knockdown of ZEBTR inhibited proliferation, colony formation, migration, and invasion of Pancreatic cancer cells[1].
The expression profile, cellular location, and distribution of ZEBTR[1].
Approved symbol: ZEBTR
Approved name: ZEBTR : ZEB1 transcriptional regulator RNA
HGNC ID:53967
Alias symbols: LncRNA-BX111
Entrez Gene: 113391337
Characteristics
Function
- ZEBTR promotes the proliferation and invasion of pancreatic cancer cells. Mechanically, BX111 activated transcription of ZEB1, a key regulator for epithelia-mesenchymal transition (EMT), via recruiting transcriptional factor Y-box protein (YB1) to its promoter region[1].
- In addition, ZEBTR contributes to the hypoxia-induced EMT of pancreatic cells by regulating expression of ZEB1 and its downstream proteins E-cadherin and MMP2[1].
Regulation
ZEBTR transcription is induced by hypoxia-inducible factor (HIF-1α) in response to hypoxia[1].
Diseases
Pancreatic cancer [1].
Expression
ZEBTR is overexpressed in human Pancreatic cancer[1].
Evolution
Sequence
>BX111887.1 BX111887 Soares_testis_NHT Homo sapiens cDNA clone IMAGp998N224461; IMAGE:1755477 5', mRNA sequence
000001 GCGCCCCACC CCGAAGCCCG GGCTGCGAGG CGGAGTCAGG GCCCCCTCAG CTCCACCCCG AAGCTTGGCA TGATTTGCCA 000080
000081 TTTTACTGCT CCTCTGGAAT CTGTGCTTCC TCCCGAGCGC AGGAGGTTCC CCTGCCGCGG CTGCCGGCCC CAGGACCTGG 000160
000161 ATGGAGATCG CCCGAGGAGA ATCCGTTCTC CTGGTCACAC TACAGAGGCC TAGGGGGACG AGACCTGCGG GGCCTGTCCG 000240
000241 GACCCGAGGC GGCGCTCGGG ATGGTCTCCC GTGGAGCAGA AACGCCGTTT CCTGGTATTT ACAACCCTCC CGACTCCCGG 000320
000321 GGAGAGGGCG GCATAGGCAG CCAATCAGGA TGCAGTCGTC TCTAAAGGTC AGGGTGACAC ACATTTCCCA AGATCATTCA 000400
000401 CGGACTTCGC CCTTCGATGC CTTGTTCTCA TGACAAAACC TGGCTGCCAG CACTTAATGT GATTTCCCCC CATCTCTGGC 000480
000481 AACTGAGAGA ATAAAAAACT
000081 TTTTACTGCT CCTCTGGAAT CTGTGCTTCC TCCCGAGCGC AGGAGGTTCC CCTGCCGCGG CTGCCGGCCC CAGGACCTGG 000160
000161 ATGGAGATCG CCCGAGGAGA ATCCGTTCTC CTGGTCACAC TACAGAGGCC TAGGGGGACG AGACCTGCGG GGCCTGTCCG 000240
000241 GACCCGAGGC GGCGCTCGGG ATGGTCTCCC GTGGAGCAGA AACGCCGTTT CCTGGTATTT ACAACCCTCC CGACTCCCGG 000320
000321 GGAGAGGGCG GCATAGGCAG CCAATCAGGA TGCAGTCGTC TCTAAAGGTC AGGGTGACAC ACATTTCCCA AGATCATTCA 000400
000401 CGGACTTCGC CCTTCGATGC CTTGTTCTCA TGACAAAACC TGGCTGCCAG CACTTAATGT GATTTCCCCC CATCTCTGGC 000480
000481 AACTGAGAGA ATAAAAAACT
Labs working on this lncRNA
- Department of Pancreatic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Shi-jiang Deng, Heng-yu Chen, Zeng Ye, Shi-chang Deng, Shuai Zhu, Zhu Zeng, Chi He, Ming-liang Liu, Kang Huang1, Jian-xin Zhong, Feng-yu Xu, Qiang Li1, Yang Liu1, Chun-you Wang and Gang Zhao. Hypoxia-induced LncRNA-BX111 promotes metastasis and progression of pancreatic cancer through regulating ZEB1 transcription. Oncogene. 2018 Nov;37(44):5811-5828.
