ZKSCAN2-DT
ZKSCAN2-DT promote the HCC tumourigenesis and progression via various related genes.[1]
Contents
Annotated Information
Name
Approved symbol：ZKSCAN2-DT
Approved name：ZKSCAN2 divergent transcript
HGNC ID：53912
Alias symbol：CTD-2547G23.4
RefSeq ID：NR_170220
Characteristics
location:16p12.1 ZKSCAN2-DT depletion in Huh-7 cell line led to S phase arrest.[1]
Function
ZKSCAN2-DT play a key role in the progress of HCC through four hub genes, SRC, CREBBP, ADCY8 and PPARA.[1]
Regulation
Please input information here.
Expression
The increased expression levels of ZKSCAN2-DT are associated with the neoplasm histologic grade and vascular tumour cell type. The expression of ZKSCAN2-DT is significantly downregulated in ZKSCAN2-DT knockdown cells.[1] The relative expression level ofZKSCAN2-DT in HCC is consistently higher than that in adjacent non-cancerous tissues.[1]
Disease
Hepatocellular carcinoma(HCC). [1]
Labs working on this lncRNA=
- Department of Medical Ultrasonics, First Affiliated Hospital of Guangxi Medical University, Nanning, 530021 Guangxi Zhuang Autonomous Region People's Republic of China. [1]
- Department of Pathology, First Affiliated Hospital of Guangxi Medical University, Nanning, 530021 Guangxi Zhuang Autonomous Region People's Republic of China. [1]
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 Wen DY, Lin P, Liang HW, Yang X, Li HY, He Y, Yang H, Chen G. Up-regulation of CTD-2547G23.4 in hepatocellular carcinoma tissues and its prospective molecular regulatory mechanism: a novel qRT-PCR and bioinformatics analysis study. Cancer Cell Int. 2018 May 11;18:74. doi: 10.1186/s12935-018-0566-3. PMID: 29780284; PMCID: PMC5948809.
