View source for GNG12-AS1

==Annotated Information==
===Approved Symbol===
GNG12-AS1:GNG12 antisense RNA 1
===Characteristics===
GNG12-AS1 is an RNAPII Transcript with H3K36me3 Signatures of Transcribed Gene.<ref name="ref1" />

===Regulation===
Neoplastic silencing of the normally active DIRAS3 allele reduces transcription of the GNG12-AS1 lncRNA in cis but does not affect its transcription on the homologous chromosome with the constitutively silent imprinted DIRAS3 allele. In addition, demethylation of a cancer cell line with loss of DIRAS3 Imprinting Leads to upregulation of DIRAS3 Expression and a Decrease in the Levels of GNG12-AS1 Transcripts.<ref name="ref1" />
===Expression===
DIRAS3 and GNG12-AS1 are coexpressed in several tissues and reduced in breast cancer. GNG12-AS1 has several splice variants, some splice variants of GNG12-AS1 are allele specific, all of which initiate from a single transcription start site. In placenta tissue and normal cell lines, GNG12-AS1 is biallelically expressed but some isoforms are allele-specifically spliced.<ref name="ref1" />
===Sequence===
>gi|338827688|ref|NR_040077.1| Homo sapiens GNG12 antisense RNA 1 (GNG12-AS1), long non-coding RNA
<dnaseq>TTTCCTTCTCGACCCACTTGTTTGTATACAACCACGCCCGGCAGGATGACCACCAGATGACCGGCCGCAGCAATGCCTCCACTCAGTCCCAGTTGGGCAAAGTTTCACTCCACTGCGGCGACGTGAACAAGAATCACGGCTTCCTTATCGTACCTGCCACAACACATGGGAATTATGGGAGTACAATTTAAGATGAGATATGGATGAGAACACAGAGCCAAACCATATCAACTCTATCTTCATGTTTGTTTACATTTCTCTCAACTGTATGTTTTGTGACCCAGAATGTGATCCTGGTAAACATTCCATTTGAGAAGAATGTGTATTCTGCTGTTGTTGGAAGCTGCGTTGTCATTGATGAAGGAATATTTCGAAGCGCTGAACAATTCTTGATAAAGTTCCGAAACAAACAAAGCACAATCTTCCCTCGATTTACATGGGAGTTGCATTCCTGGAAAATTCAGTATATTTTAAAACCATGCAAAATATCCTTTTAAAAAAATATGTAACATGGAGTTTAGGACCAAGGCTCAGAATATTTCCAATCCATGGTTGGGTGCGGAACCTGCGGATACAGAGGACTGACTATAATATCAAGAGATCATAAGGCTGTCGGAATGGACTCTTTGTGGCAATAAGATACCATATTATAAACAGGACCCAAGGTCATGCCAGGAGGCTCGTGTGGTCCCTGTTTGTCATCCAGTCAATACGGCCATCAGCTTCTGGCCCCAGACACCTTTCCTCTGCACTGTGGCACAGAGGAGCAGACTGCTTTGGAGGGCAGCTTCCTGGGAGCTCCAGGGACCCTGGCCAGGCGGCCACTGCCACTGACTTCCTCGGCTCACTGAGCCCGTGCCTGCAGCTCTCGTGTTTCCTCTGTGCTGCAGTGGACGCTTATCTTCCCCCGATGGCACATTTCTTTGTCACAGACAGGACCCTCACTGGCAGTCGGAGGACATCAAGCCCTAGTACAGGAAGGGACATTTTCACACTAATCTGTGCCAGCTGGAGCAGTCCTGCCATCTGAACATCATATTTTGGAACCCTGAGAAGCTAGGATGCAGTTAACAGCTAGATGTCAATTCCCTGCAGGCAGAGACCAGTTCTCTGCTGCCATGTCTTTAAGGCCTGATGCACCATAGATTAATTCAAATCCAGTGTCTACCACTCACTCGGCTTAATGTAAGACAAGATGAAGACTCCAGACTTCAGAACTTCAGTGTCCGCAGATGAGGATTTTAAATGCTTCGCCTACAACCTCAATTGTTGTGGAGCCAAAGATGCAACAGCTTTGAAGAATAGAAGAATTACTCTATATTTGTCAGGATCTACGTGGCAAACAAGCGCCACTTGGCTTACATTACTTGCCTGGCTTGGATCCCATGGAATGGAGGAGCATTGGAACCAAGAGGAAAAAAATTAAAGTGCTTTGGGACAGCGAGCCAAACTCTTACATAGTATTTGAAATGGTGTGGCAAACATGAAATTATTTTAGGCTCAAGATTGGTGCTAGTTTTTTACCCTCTTTTTGAAAAAATAGTAAAATGCACATAAAGGGCCCTGCCAGAGGTTTAGCTCATAAAATCTGCCAATCATTGGATGTGCTAATTGGTGTAGCAATCCAGTGGTGGCCTGGATTAGGACTCAAAAACTGACCCTTACCACCCTTGGTGTCCTGCAGCAAAGACAGCCTAAATCGAAAAGACTGATGGAAGTATATCAAATTACGAATTTCTCTATCCCTGAAAAATGCCTGCAATTTCTGTTTCTCCATCACTCCAGAAATACTCAAAACAGCAAAAATTAAATACATATGAAGTGAACACAAAAGACCTCCACAGAAAAATCAGTGGCTCATCTGTTGACGCTATTGCTCATTGCTCGGCTGGCCAGTCATCTGGGCTAAGTTTTGACTTTGGGCCAGTGCTTCAAAATCAGCAACCTTTCAGCCAAAAGACTGTGGAATGCAGCCAAGACCACCTGTGGAAAGTGAATTATAGCATCTTTAATTTACTACCTTGGGCTATGATGTCAGAAACCCAGCATGGAGGGCGCACCAGTTCTTGTGTGGGAAATCTCTCAGAGCCCCCATGGAGGCCCCCAAAGTGGCTCTGGCAAAGCTGTAGGGGTGGAGGTAACAAAAAAGGGGACACCTGGCTCTCCTTCTTAAATCAGCTCACCATGGGCACACATTTATATTGGAATTTTAGGGTCAGAAAATACCAAAATTAAATCTTCTAGAAG</dnaseq>

==Labs working on this lncRNA==
* Cancer Research UK, Robinson Way, Cambridge CB2 0RE, UK.
==References==
<references>
<ref name="ref1"> 
Niemczyk M, Ito Y, Huddleston J, Git A, Abu-Amero S, Caldas C, Moore GE,
Stojic L, Murrell A. Imprinted chromatin around DIRAS3 regulates alternative
splicing of GNG12-AS1, a long noncoding RNA. Am J Hum Genet. 2013 Aug.
8;93(2):224-35
</ref>
</references>