Difference between revisions of "ATB"

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(Created page with "==Annotation== ===Name=== ATB ===Alias=== NA ===Disease=== Disease: breast cancer [http://www.ncbi.nlm.nih.gov/pubmed/25871474 (PMID:25871474)] Dysfunction type: regulation...")
 
 
(One intermediate revision by the same user not shown)
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==Annotation==
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''ATB'', is a novel cancer-related long noncoding RNA
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===Name===
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==Annotated Information==
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ATB
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===Approved Symbol===
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''ATB''
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===Approved Name===
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''ATB'': lncRNA-activated by TGF-β (lncRNA-ATB).  <ref name="ref1" />
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lncRNA-AL589182.3  <ref name="ref1" />
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ENST00000493038  <ref name="ref1" />
  
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===Alias===
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===Characteristics===
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NA
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''ATB'' is a 2 exon transcripts which strechtes over 80kb located on chromosome 14  <ref name="ref1" />
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''ATB'' is physically associated with the miR-200 family  <ref name="ref1" /> <ref name="ref2" />
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''ATB'' is poly (A)-negative and mainly located in the cytoplasm  <ref name="ref1" />
  
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===Disease===
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===Function===
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Disease: breast cancer [http://www.ncbi.nlm.nih.gov/pubmed/25871474 (PMID:25871474)]
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''ATB'' mediates mechanisms involved in cancer progression  <ref name="ref1" /> <ref name="ref2" /> <ref name="ref3" /> <ref name="ref4" />
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''ATB'' is found to be physically associated with the miR-200 family and may function as a ceRNA  <ref name="ref2" />
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''ATB'' specially increases the stability of IL-11 mRNA, which depends on the binding of IL-11 mRNA  <ref name="ref1" />
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''ATB'' Interacts with IL-11 mRNA and Activates IL-11/STAT3 Signaling in HCC Cells  <ref name="ref1" />
  
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Dysfunction type: regulation
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===Regulation===
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''ATB'' is regulated by Transforming growth factor β (TGF-β)  <ref name="ref1" />
  
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Description: LncRNA-ATB promotes trastuzumab resistance and invasion-metastasis cascade in breast cancer.
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===Diseases===
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*Breast cancer <ref name="ref3" />
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*Colorectal cancer <ref name="ref3" />
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*Gastric cancer <ref name="ref3" />
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*Glioma <ref name="ref3" />
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*Hepatocellular carcinoma <ref name="ref3" />
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*Keloid <ref name="ref3" />
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*Lung cancer <ref name="ref3" />
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*Pancreatic cancer <ref name="ref3" />
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*Prostate cancer <ref name="ref3" />
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*Renal cell carcinoma <ref name="ref3" />
  
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===Expression===
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''ATB'' is a promising candidate among all tumour-associated lncRNAs and is overexpressed in numerous human cancers but downregulated in pancreatic cancer. Evidence regarding the abnormal expression, molecular mechanism and clinical significance of lncRNA-''ATB'' shows that ''ATB'' is one of the most important regulatory RNAs in human cancer the lncRNA-''ATB''/miR-200s/ZEB axis playedan important role in TGF-β-induced EMT to promote invasion and metastasis <ref name="ref1" /><ref name="ref3" />
  
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===Function===
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==Labs working on this lncRNA==
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Function Mechanism: NA [http://www.ncbi.nlm.nih.gov/pubmed/27176634 (PMID:27176634)]
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*Department of Administration and Department of Aristogenesis, No. 202 Hospital of PLA, No. 5, Shenyang, 110003, Liaoning Province, P.R. China
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*Department of Medical Genetics, Second Military Medical University, Shanghai, 200433, China
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*Department of Hepatopancreatobiliary Surgery, Second Affiliated Hospital of Harbin Medical University, Harbin, China
  
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Biological Process: pathogenic process
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==References==
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<references>
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<ref name="ref1"> Yuan J-h, Yang F, Wang F, Ma J-z, Guo Y-j, Tao Q-f et al. A long noncoding RNA activated by TGF-β promotes the invasion-metastasis cascade in hepatocellular carcinoma[J]. Cancer cell. 2014, 25(5):666-681.
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</ref>(1)
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<ref name="ref2"> Burk U, Schubert J, Wellner U, Schmalhofer O, Vincan E, Spaderna S et al. A reciprocal repression between ZEB1 and members of the miR‐200 family promotes EMT and invasion in cancer cells[J]. EMBO reports. 2008, 9(6):582-589.
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</ref>(2)
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<ref name="ref3"> Li J, Li Z, Zheng W, Li X, Wang Z, Cui Y et al. Lnc RNA‐ATB: An indispensable cancer‐related long noncoding RNA[J]. Cell proliferation. 2017, 50(6):e12381.
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</ref>(3)
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<ref name="ref4"> Xiao H, Zhang F, Zou Y, Li J, Liu Y & Huang W. The Function and Mechanism of Long Non-coding RNA-ATB in Cancers[J]. Frontiers in physiology. 2018
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</ref>(4)
  
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Description: biomarker
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</references>

Latest revision as of 03:17, 14 November 2018

ATB, is a novel cancer-related long noncoding RNA

Annotated Information

Approved Symbol

ATB

Approved Name

ATB: lncRNA-activated by TGF-β (lncRNA-ATB). [1] lncRNA-AL589182.3 [1] ENST00000493038 [1]

Characteristics

ATB is a 2 exon transcripts which strechtes over 80kb located on chromosome 14 [1] ATB is physically associated with the miR-200 family [1] [2] ATB is poly (A)-negative and mainly located in the cytoplasm [1]

Function

ATB mediates mechanisms involved in cancer progression [1] [2] [3] [4] ATB is found to be physically associated with the miR-200 family and may function as a ceRNA [2] ATB specially increases the stability of IL-11 mRNA, which depends on the binding of IL-11 mRNA [1] ATB Interacts with IL-11 mRNA and Activates IL-11/STAT3 Signaling in HCC Cells [1]

Regulation

ATB is regulated by Transforming growth factor β (TGF-β) [1]

Diseases

  • Breast cancer [3]
  • Colorectal cancer [3]
  • Gastric cancer [3]
  • Glioma [3]
  • Hepatocellular carcinoma [3]
  • Keloid [3]
  • Lung cancer [3]
  • Pancreatic cancer [3]
  • Prostate cancer [3]
  • Renal cell carcinoma [3]

Expression

ATB is a promising candidate among all tumour-associated lncRNAs and is overexpressed in numerous human cancers but downregulated in pancreatic cancer. Evidence regarding the abnormal expression, molecular mechanism and clinical significance of lncRNA-ATB shows that ATB is one of the most important regulatory RNAs in human cancer the lncRNA-ATB/miR-200s/ZEB axis playedan important role in TGF-β-induced EMT to promote invasion and metastasis [1][3]

Labs working on this lncRNA

  • Department of Administration and Department of Aristogenesis, No. 202 Hospital of PLA, No. 5, Shenyang, 110003, Liaoning Province, P.R. China
  • Department of Medical Genetics, Second Military Medical University, Shanghai, 200433, China
  • Department of Hepatopancreatobiliary Surgery, Second Affiliated Hospital of Harbin Medical University, Harbin, China

References

  1. ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 Yuan J-h, Yang F, Wang F, Ma J-z, Guo Y-j, Tao Q-f et al. A long noncoding RNA activated by TGF-β promotes the invasion-metastasis cascade in hepatocellular carcinoma[J]. Cancer cell. 2014, 25(5):666-681.
  2. ↑ 2.0 2.1 2.2 Burk U, Schubert J, Wellner U, Schmalhofer O, Vincan E, Spaderna S et al. A reciprocal repression between ZEB1 and members of the miR‐200 family promotes EMT and invasion in cancer cells[J]. EMBO reports. 2008, 9(6):582-589.
  3. ↑ 3.00 3.01 3.02 3.03 3.04 3.05 3.06 3.07 3.08 3.09 3.10 3.11 Li J, Li Z, Zheng W, Li X, Wang Z, Cui Y et al. Lnc RNA‐ATB: An indispensable cancer‐related long noncoding RNA[J]. Cell proliferation. 2017, 50(6):e12381.
  4. ↑ Xiao H, Zhang F, Zou Y, Li J, Liu Y & Huang W. The Function and Mechanism of Long Non-coding RNA-ATB in Cancers[J]. Frontiers in physiology. 2018
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