NONHSAT089783

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Annotated Information

Name

LUST: LUCA-15-specific transcript.

Characteristics

~1.4 - 2.4 kb. Intronic, unspliced and transcribed antisense to the putative tumour suppressor gene RBM5/LUCA-15/H37, spanning introns 6 to 4 ((Rintala-Maki 2009)).

Contains SINE elements.

Expression

Originally cloned from an human bone marrow library ((Sutherland 2000)), this transcript is abundant in skeletal and cardiac muscle (as detected by Northern blot) ((Rintala-Maki 2009)).

Function

• Transfection of Jurkat T cells with a 326 bp fragment of LUST (originally termed Je2) suppresses CD95-mediated apoptosis ((Sutherland 2000)).

• Ectopic over-expression of LUST affects splicing of RBM5: it correlates with elevated expression of the full-length RBM5+5+6 splice variant, and with reduced expression of the truncated RBM5+5+6t isoform, which is cytotoxic ((Rintala-Maki 2009)).

Transcriptomic Nomeclature

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Regulation

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Allelic Information and Variation

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Evolution

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Labs working on this lncRNA

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References

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Basic Information

Transcript ID	NONHSAT089783
Source	NONCODE4.0
Same with	,
Classification	antisense
Length	1386 nt
Genomic location	chr3-:50137036..50138421
Exon number	1
Exons	50137036..50138421
Genome context
Sequence	000001 AAATGCCGCC ACAGACTTTC ACTATGTTCT CTTCACTGTC AAATGGAGAG TTTGATATAC TAAGCTTACT CTCAATGGAC 000080 000081 ATAATAGGAA TATAACAAAC TAGAAAAAAG GGAAACATTA AGATGTTTTA GTGATTACCA GACAGGTATT CAGTAGTTAA 000160 000161 CAAAGCCCTG CCAGGTAGGT AGCCATGTTT AAAGGCAGAA CAAATTCTAT AATGAAGTCC TTGGTACTGT ACTTATTCTA 000240 000241 GTAACATCAA TTTTAATATA TACAAAGCTT TTTTTTTAAA AAAAAGTCAC TCCTTTGGAA CAAACCACTC CTTCAACCTT 000320 000321 TTTTTAAAAT TGTACAGACT TGTTCCATTT TCATGAATAT CTAGACTTGG TGAGTGAAGC AACCTGATTG GCTTCCATCC 000400 000401 AGCTGGTAGC ATCTTGCAAG TGATAAAACT CCACGAAGGC GAAACCACGG CTTACACCTA GAGACAGCAT TCAGATATAG 000480 000481 ACGGGATACT TGTGTTAGTC AGTTCCTTTA TAACAGGTGA ATCTCTCTCC CACTGCTTCA ACACTGCGTG ACAAAGCCAA 000560 000561 TTGGGAAGCA GCTTTACAAA TGTGACTTGA CTTGGGGATC TTCTTGATAC TTTGCCATGG CAAGGAACAA GCCGCCTGAA 000640 000641 CTAAATGCCA CTCCATTTGA TTCCACGCTT AAAGTAACCA TGCAACCGAC TATAGTCAAA AAAAAAAAGG AGTTTATAAA 000720 000721 TCATTACTTA CCTAAGGAAA AAAAAGTCCC TAAAACAAAG TTTAAAAAAG TTCCTCAGAT GCTAACATGG TTTTCAAAGA 000800 000801 GTCACATTCC TTAGCCATGG CAAACCTTTC ATTCTGAATT CATGTGCTTG AAGACTGGGG GAATCAGGAT GTTCTTTAGG 000880 000881 GACTGAGGTG GGAATGGGGA AGAGAACAAT AATATCAGGA ACTAAGCAAG CTCTCACCTG TTTTCCTCTT CATCAGCCTC 000960 000961 ACATCCGCAG GCTGAGGGCC TTCGAAGGAC TCCATCATTT CTCGAATCTG CACAGGGTTT TACATTATTT ACAGTTAAAG 001040 001041 CTTTTGCCAC ACACTATTCC CCATGGAATA GGAATTACAT CAACTGTTTA ATTAGCCAAG TTTTTTTTTT TTTTAAGATG 001120 001121 GGAGTCTCTG TCTCTCACTC ACTTGATTGC CCAGGCTGGA GTGCAGTGGC ATGATCTCAG CTCACTGCAA CCACCACCTC 001200 001201 CTGGGTTCAA GCAATTCTCC TGCCTCAGCC TCCCGAGTAG CTGGGATTAT AGGTGTGCAC CACCATGCGT GACTGATTTT 001280 001281 TTTTTTTTTT TGAGACGGAG TCTCGCTCTG TCACCCAGGC TGGAGTACAG TGACGTGATC TCGGCTCACT TCAACCTCCA 001360 001361 CCTCCTGGAT TCAAGCGATT CTTCTG

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