Difference between revisions of "LIVAR"
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Lnc18q22.2 is mainly present in the cytoplasm.<ref name="ref1" /> | Lnc18q22.2 is mainly present in the cytoplasm.<ref name="ref1" /> | ||
===Function=== | ===Function=== | ||
| − | + | [[File:Lnc18q22.2.JPG|right|thumb|400px|'''Association of lnc18q22.2 expression with different degrees of NASH'''<ref name="ref1" />.]] | |
Lnc18q22.2 is ignificantly association with NASH (Nonalcoholic steatohepatiti)grade , lobular inflammation, and NAS (AFLD activity score). In addition, lnc18q22.2 is also significantly associated with liver steatosis and steatohepatitis(including ASH (alcoholic steatohepatit) and NASH) in 44 independent liver biopsies. | Lnc18q22.2 is ignificantly association with NASH (Nonalcoholic steatohepatiti)grade , lobular inflammation, and NAS (AFLD activity score). In addition, lnc18q22.2 is also significantly associated with liver steatosis and steatohepatitis(including ASH (alcoholic steatohepatit) and NASH) in 44 independent liver biopsies. | ||
The silencing of lnc18q22.2 expression results in reduced growth in HepG2 and IHH cells and promoted cell death in Huh7 and Hep3B cells .<ref name="ref1" /> | The silencing of lnc18q22.2 expression results in reduced growth in HepG2 and IHH cells and promoted cell death in Huh7 and Hep3B cells .<ref name="ref1" /> | ||
Revision as of 02:13, 12 September 2017
Contents
Annotated Information
Name
LIVAR:liver cell viability associated lncRNA.
lnc18q22.2[1]
Characteristics
The total length of the lnc18q22.2 transcript on chromosome 18 is estimated to be 633 bp.[1]
Cellular Localization
Lnc18q22.2 is mainly present in the cytoplasm.[1]
Function
Lnc18q22.2 is ignificantly association with NASH (Nonalcoholic steatohepatiti)grade , lobular inflammation, and NAS (AFLD activity score). In addition, lnc18q22.2 is also significantly associated with liver steatosis and steatohepatitis(including ASH (alcoholic steatohepatit) and NASH) in 44 independent liver biopsies. The silencing of lnc18q22.2 expression results in reduced growth in HepG2 and IHH cells and promoted cell death in Huh7 and Hep3B cells .[1]
Expression
Lnc18q22.2 is predominantly expressed in liver tissue and in the HCC (hepatocellular carcino)cell line HepG2.[1]
Diseases
Nonalcoholic steatohepatiti[1]
Labs working on this lncRNA
- Department of Pediatrics, Molecular Genetics, University Medical Center Groningen, Groningen, The Netherlands.
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Atanasovska B, Rensen SS, van der Sijde MR, Marsman G, Kumar V, Jonkers I, Withoff S, Shiri-Sverdlov R, Greve JWM, Faber KN, Moshage H, Wijmenga C, van de Sluis B, Hofker MH, Fu J. A liver-specific long noncoding RNA with a role in cell viability is elevated in human nonalcoholic steatohepatitis. Hepatology. 2017 Sep;66(3):794-808.
