Difference between revisions of "LINC00319"
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===Expression=== | ===Expression=== | ||
| + | LINC00319 is up-regulated in human primary lung adenocarcinoma tissues<ref name="ref1" />. | ||
===Regulation=== | ===Regulation=== | ||
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Linc00319 promotes cell proliferation and invasion in lung cancer cells by directly binding with and downregulating the tumor suppressor miR-32.<ref name="ref1" /> | Linc00319 promotes cell proliferation and invasion in lung cancer cells by directly binding with and downregulating the tumor suppressor miR-32.<ref name="ref1" /> | ||
| + | |||
===Disease=== | ===Disease=== | ||
lung cancer <ref name="ref1" /> | lung cancer <ref name="ref1" /> | ||
| + | |||
| + | lung adenocarcinoma carcinogenesis <ref name="ref2" /> | ||
===Evolution=== | ===Evolution=== | ||
Revision as of 05:30, 12 August 2019
Contents
Annotation
Name
Approved symbol: LINC00319
Approved name: long intergenic non-protein coding RNA 319
HGNC ID: HGNC:19730
Previous symbols: C21orf125; NCRNA00319
Previous names: chromosome 21 open reading frame 125; non-protein coding RNA 319
Alias symbols: PRED49; FLJ38036
RefSeq ID: NR_026960
LncBook ID: HSALNT0289323
Characteristics
Functional domains of 7SK RNA((Diribarne 2009))
Expression
LINC00319 is up-regulated in human primary lung adenocarcinoma tissues[1].
Regulation
Function
Model of hLarp7 recognition of the 7SK 3′end and mechanism of assembly of core 7SK RNP((Eichhorn 2018))
Linc00319 promotes cell proliferation and invasion in lung cancer cells by directly binding with and downregulating the tumor suppressor miR-32.[1]
Disease
lung cancer [1]
lung adenocarcinoma carcinogenesis [2]
Evolution
Please input evolution information here.
Labs working on this lncRNA
- College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi 712100, China.[1]
- Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang 441021, China.[2]
References
- ↑ 1.0 1.1 1.2 1.3 Zhou B, Yuan W and Li X. Long Intergenic Noncoding RNA 319 (linc00319) Promotes Cell Proliferation and Invasion in Lung Cancer Cells by Directly Downregulating the Tumor Suppressor MiR-32[J]. Oncol Res, 2017.
- ↑ 2.0 2.1 Zhang ZW, Chen JJ, Xia SH, et al. Long intergenic non-protein coding RNA 319 aggravates lung adenocarcinoma carcinogenesis by modulating miR-450b-5p/EZH2[J]. Gene, 2018, 650: 60-67.
