Difference between revisions of "LINC00319"
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Linc00319 promotes cell proliferation and invasion in lung cancer cells by directly binding with and downregulating the tumor suppressor miR-32.<ref name="ref1" /> | Linc00319 promotes cell proliferation and invasion in lung cancer cells by directly binding with and downregulating the tumor suppressor miR-32.<ref name="ref1" /> | ||
Revision as of 05:39, 12 August 2019
Contents
Annotation
Name
Approved symbol: LINC00319
Approved name: long intergenic non-protein coding RNA 319
HGNC ID: HGNC:19730
Previous symbols: C21orf125; NCRNA00319
Previous names: chromosome 21 open reading frame 125; non-protein coding RNA 319
Alias symbols: PRED49; FLJ38036
RefSeq ID: NR_026960
LncBook ID: HSALNT0289323
Characteristics
Long intergenic non-protein coding RNA 319 (LINC00319) (NR_152722), is located on chromosome 21q22.3 and has a transcript length of 2901 nucleotides[1].
Expression
LINC00319 was significantly up-regulated in lung adenocarcinoma tissues compared with normal lung tissues[1].
Reported to be highly expressed in lung cancer[2].
Regulation
Function
Linc00319 promotes cell proliferation and invasion in lung cancer cells by directly binding with and downregulating the tumor suppressor miR-32.[2]
LINC00319 was also shown to regulate the miR-450b-5p targeted gene enhancer of zeste homolog 2 (EZH2) by functioning as a competitive endogenous RNA (ceRNA) for miR-450b-5p in lung adenocarcinoma, thereby inhibiting the expression of EZH2 and promoting lung adenocarcinoma cell proliferation.[1].
Disease
lung cancer [2]
lung adenocarcinoma carcinogenesis [1]
Evolution
Please input evolution information here.
Labs working on this lncRNA
- College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi 712100, China.[2]
- Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang 441021, China.[1]
References
- ↑ 1.0 1.1 1.2 1.3 1.4 Zhang ZW, Chen JJ, Xia SH, et al. Long intergenic non-protein coding RNA 319 aggravates lung adenocarcinoma carcinogenesis by modulating miR-450b-5p/EZH2[J]. Gene, 2018, 650: 60-67.
- ↑ 2.0 2.1 2.2 2.3 Zhou B, Yuan W and Li X. Long Intergenic Noncoding RNA 319 (linc00319) Promotes Cell Proliferation and Invasion in Lung Cancer Cells by Directly Downregulating the Tumor Suppressor MiR-32[J]. Oncol Res, 2017.
