Difference between revisions of "NONHSAT017524"
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ID Kcnq1ot1 | ID Kcnq1ot1 | ||
Name Kcnq1ot1: Kcnq1 opposite transcript 1,LIT1: long QT intronic transcript 1 | Name Kcnq1ot1: Kcnq1 opposite transcript 1,LIT1: long QT intronic transcript 1 | ||
| − | Characteristics 91 kb, unspliced; imprinted (paternally expressed), it is transcribed from intron 10 of the maternally expressed Kncq1 (KvLQT1) gene from a CpG island that is the imprinting control region (IC2) ([www.ncbi.nlm.nih.gov/pubmed/10393948 (Smilinich 1999)]). This imprinted region contains at least eight genes that are expressed exclusively or preferentially from the maternal allele ([www.ncbi.nlm.nih.gov/pubmed/21345374 (Kanduri 2011)]). | + | Characteristics 91 kb, unspliced; imprinted (paternally expressed), it is transcribed from intron 10 of the maternally expressed Kncq1 (KvLQT1) gene from a CpG island that is the imprinting control region (IC2) ([http://www.ncbi.nlm.nih.gov/pubmed/10393948 (Smilinich 1999)]). This imprinted region contains at least eight genes that are expressed exclusively or preferentially from the maternal allele ([http://www.ncbi.nlm.nih.gov/pubmed/21345374 (Kanduri 2011)]). |
| − | Expression Nuclear localised. <br /> Expressed in most human tissues.<br />Mouse RNA found to be highly unstable with a half-life <2 hr in N2A (neuroblastoma) cells ([www.ncbi.nlm.nih.gov/pubmed/22406755 (Clark 2012)]). | + | Expression Nuclear localised. <br /> Expressed in most human tissues.<br />Mouse RNA found to be highly unstable with a half-life <2 hr in N2A (neuroblastoma) cells ([http://www.ncbi.nlm.nih.gov/pubmed/22406755 (Clark 2012)]). |
| − | Function PSummary: Kcnq1ot1 has a role in the organization of a tissue/lineage-specific nuclear domain involved in epigenetic silencing of the Kcnq1 imprinting control region. <br />Genes imprinted by kcnq1ot1 include Kcnq1, Cdkn1c, Slc22a18 and Phlda2, which are ubiquitously imprinted and Cd81, Osbpl5, Tssc4, Tspan32 and Ascl2, which are only imprinted in placenta (reviewed in [www.ncbi.nlm.nih.gov/pubmed/21345374 (Kanduri 2011)]. An expansion of the Kncq1ot1 imprinted domain to include splice variants of Th and Ins2 was recently described ([www.ncbi.nlm.nih.gov/pubmed/21576366 (Jones 2011)]).<br />Kcnq1ot1 silences genes by coating chromatin and recruiting repressive chromatin remodeling complexes such as G9a, PRC1 and PRC2 ([www.ncbi.nlm.nih.gov/pubmed/18848501 (Terranova 2008)], [www.ncbi.nlm.nih.gov/pubmed/18951091 (Pandey 2008)], [www.ncbi.nlm.nih.gov/pubmed/15516932 (Umlauf 2004)], [www.ncbi.nlm.nih.gov/pubmed/21172659 (Zhao 2010)]) .<br />Kcnq1ot1 transcript has a modular structure, the silencing element (that mediates the epigenetic silencing and directs the imprinted locus to a heterochromatin environment in the perinucleolar region) appears to be a short <1kb conserved sequence near the 5' of the transcript ([www.ncbi.nlm.nih.gov/pubmed/18299392 (Mohammad 2008)]).<br />Kcnq1ot1 forms a silenced subdomain ([www.ncbi.nlm.nih.gov/pubmed/18848501 (Terranova 2008)])([www.ncbi.nlm.nih.gov/pubmed/19144718 (Redrup 2009)]) commonly localised to the perinucleolar region during S phase ([www.ncbi.nlm.nih.gov/pubmed/18299392 (Mohammad 2008)]). The silenced subdomain may be important to the maintenance of transcriptional repression.<br />Kcnq1ot1 interacts with Dnmt1 and recruits it to somatically acquired differentially methylated regions (DMRs) of imprinted genes ([www.ncbi.nlm.nih.gov/pubmed/20573698 (Mohammad 2010)]).<br />In vivo knockout study shows that paternal inheritance of a deletion encompassing an 890-bp (Delta890) silencing domain downstream of the Kcnq1ot1 promoter leads reduced interaction with DNMT1 and to selective incomplete relaxation of the imprinting of imprinted genes in a tissue-specific manner ([www.ncbi.nlm.nih.gov/pubmed/20573698 (Mohammad 2010)]).<br /> Delta890 showed altered DNA methylation at somatically acquired DMRs but not in histone modifications of the ubiquitously imprinted genes. Thus, it has been proposed that the ubiquitous and placental-specific imprinting of genes within the Kcnq1 domain might be mediated by distinct mechanisms, and Kcnq1ot1 RNA might mediate the silencing of ubiquitously imprinted genes by maintaining allele-specific methylation through its interactions with Dnmt1 ([www.ncbi.nlm.nih.gov/pubmed/20573698 (Mohammad 2010)]). | + | Function PSummary: Kcnq1ot1 has a role in the organization of a tissue/lineage-specific nuclear domain involved in epigenetic silencing of the Kcnq1 imprinting control region. <br />Genes imprinted by kcnq1ot1 include Kcnq1, Cdkn1c, Slc22a18 and Phlda2, which are ubiquitously imprinted and Cd81, Osbpl5, Tssc4, Tspan32 and Ascl2, which are only imprinted in placenta (reviewed in [http://www.ncbi.nlm.nih.gov/pubmed/21345374 (Kanduri 2011)]. An expansion of the Kncq1ot1 imprinted domain to include splice variants of Th and Ins2 was recently described ([http://www.ncbi.nlm.nih.gov/pubmed/21576366 (Jones 2011)]).<br />Kcnq1ot1 silences genes by coating chromatin and recruiting repressive chromatin remodeling complexes such as G9a, PRC1 and PRC2 ([http://www.ncbi.nlm.nih.gov/pubmed/18848501 (Terranova 2008)], [http://www.ncbi.nlm.nih.gov/pubmed/18951091 (Pandey 2008)], [http://www.ncbi.nlm.nih.gov/pubmed/15516932 (Umlauf 2004)], [http://www.ncbi.nlm.nih.gov/pubmed/21172659 (Zhao 2010)]) .<br />Kcnq1ot1 transcript has a modular structure, the silencing element (that mediates the epigenetic silencing and directs the imprinted locus to a heterochromatin environment in the perinucleolar region) appears to be a short <1kb conserved sequence near the 5' of the transcript ([http://www.ncbi.nlm.nih.gov/pubmed/18299392 (Mohammad 2008)]).<br />Kcnq1ot1 forms a silenced subdomain ([http://www.ncbi.nlm.nih.gov/pubmed/18848501 (Terranova 2008)])([http://www.ncbi.nlm.nih.gov/pubmed/19144718 (Redrup 2009)]) commonly localised to the perinucleolar region during S phase ([http://www.ncbi.nlm.nih.gov/pubmed/18299392 (Mohammad 2008)]). The silenced subdomain may be important to the maintenance of transcriptional repression.<br />Kcnq1ot1 interacts with Dnmt1 and recruits it to somatically acquired differentially methylated regions (DMRs) of imprinted genes ([http://www.ncbi.nlm.nih.gov/pubmed/20573698 (Mohammad 2010)]).<br />In vivo knockout study shows that paternal inheritance of a deletion encompassing an 890-bp (Delta890) silencing domain downstream of the Kcnq1ot1 promoter leads reduced interaction with DNMT1 and to selective incomplete relaxation of the imprinting of imprinted genes in a tissue-specific manner ([http://www.ncbi.nlm.nih.gov/pubmed/20573698 (Mohammad 2010)]).<br /> Delta890 showed altered DNA methylation at somatically acquired DMRs but not in histone modifications of the ubiquitously imprinted genes. Thus, it has been proposed that the ubiquitous and placental-specific imprinting of genes within the Kcnq1 domain might be mediated by distinct mechanisms, and Kcnq1ot1 RNA might mediate the silencing of ubiquitously imprinted genes by maintaining allele-specific methylation through its interactions with Dnmt1 ([http://www.ncbi.nlm.nih.gov/pubmed/20573698 (Mohammad 2010)]). |
| − | Conservation Patches of highly conserved repeats in 5' side of transcript, which contains the silencing domain (www.ncbi.nlm.nih.gov/pubmed/18299392 (Mohammad 2008)]). Promoter control elements are highly conserved between mouse and humans, including CCAAT elements that are targets of NF-Y regulation (www.ncbi.nlm.nih.gov/pubmed/15459184 (Pandey 2004)]), as well as the position of CpG islands in the imprinting control region ([www.ncbi.nlm.nih.gov/pubmed/15590939 (Paulsen 2004)]). | + | Conservation Patches of highly conserved repeats in 5' side of transcript, which contains the silencing domain ([http://www.ncbi.nlm.nih.gov/pubmed/18299392 (Mohammad 2008)]). Promoter control elements are highly conserved between mouse and humans, including CCAAT elements that are targets of NF-Y regulation ([http://www.ncbi.nlm.nih.gov/pubmed/15459184 (Pandey 2004)]), as well as the position of CpG islands in the imprinting control region ([http://www.ncbi.nlm.nih.gov/pubmed/15590939 (Paulsen 2004)]). |
| − | Misc (Syndromes and diseases associated, eg Beckwith-Wiedemann syndrom, and cancers (see references list):<br />Associated with multiple balanced chromosomal rearrangements in Beckwith-Wiedemann syndrome (BWS) and an additional break-point in embryonal rhabdoid tumours; in particular, aberrant methylation of the CpG island associated with Kcnq1ot1 promoter is strongly associated with cancer risk and specific birth defects in BWS ([www.ncbi.nlm.nih.gov/pubmed/10393948 (Smilinich 1999)])).<br />For review on Kcnq1ot1 mechanism of action see ([www.ncbi.nlm.nih.gov/pubmed/21345374 (Kanduri 2011)]). | + | Misc (Syndromes and diseases associated, eg Beckwith-Wiedemann syndrom, and cancers (see references list):<br />Associated with multiple balanced chromosomal rearrangements in Beckwith-Wiedemann syndrome (BWS) and an additional break-point in embryonal rhabdoid tumours; in particular, aberrant methylation of the CpG island associated with Kcnq1ot1 promoter is strongly associated with cancer risk and specific birth defects in BWS ([http://www.ncbi.nlm.nih.gov/pubmed/10393948 (Smilinich 1999)])).<br />For review on Kcnq1ot1 mechanism of action see ([http://www.ncbi.nlm.nih.gov/pubmed/21345374 (Kanduri 2011)]). |
</tab>| | </tab>| | ||
}} | }} | ||
Revision as of 12:29, 6 October 2014
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Contents
Annotated Information
Transcriptomic Nomeclature
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Function
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Regulation
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Expression
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Allelic Information and Variation
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Evolution
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You can also add sub-section(s) at will.
Labs working on this lncRNA
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References
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Basic Information
| Transcript ID |
NONHSAT017524 |
| Source |
NONCODE4.0 |
| Same with |
, |
| Classification |
antisense |
| Length |
59461 nt |
| Genomic location |
chr11-:2661768..2721228 |
| Exon number |
1 |
| Exons |
2661768..2721228 |
| Genome context |
|
| Sequence |
000001 AGGCAGAACG GTCGCCGCGT CGCCTCAGCA CGGACCTCCA GGGAGCTCCT CAGCAAGATC CTGCCAGGGC GCCCCTCAGC 000080
000081 GCGATTCTGC CGGGGTGCCT CTCAGCGTGG TCCTCCCCGG GGCTCCTCAG CACGATTCTC CCGGTGCGCC CCTCAGCGCG 000160 000161 GTCCTCCTCG GTGCGTCAGT CATCGTGGTT CTCCCCGGCG CGCCCCTCGG CGCGGTTCTC CTCGGGGCTC CTCAGCGCGG 000240 000241 CGCTCTTCTG GGGGCTCCTC GGCGCAGTTC TCCCCGGGGA CTCCTCGGCG CCGTTCTCCT CGGGGCACCC GGGGCTTTTC 000320 000321 GGCGCGGTTC TCCCCGGGGG TTCTTCGGCG CGGTTGTCCC CGGGGGTTCT TCGGCGCGGT TCTCTCCGGG GGCCTCTCGC 000400 000401 CGCGGTTCTG TTCTCCCCGG GGGCTCCTCA GCATGGTTCT CCTCCGCGCG GTCCTCCCTG GGCCTCCTCA GCGCGGCACT 000480 000481 CTCCTGGGGG CTCCTCAGCG CGGCACTCTC CCCGGGGGCT CCTCAGCGCG GCACTCTCCC GGCGGCTCCT CAGTGCGGTT 000560 000561 CTCCCAGACT CTCCTCAGCG CGGCCCTCCC CATCTCTCTG GGAGGGTTTG AACACGGTCA GCACGGACCT GGGCGGACGG 000640 000641 CGCGGGACGG GTGATCACTG GCGTTGCTGA GGTGAGCTGT GTGCCCCGCG GCCGTCCCAG ATCACAGGCG TCAGCAGTGC 000720 000721 AGCCTGGCCT GGGCAGTGCG CTCCCATCTG CACCTTATGG ACAGCGTGGC CAGGGTCGAG GTCCGAGTTC CTGGCCGCGT 000800 000801 CCCAAGGATC GGATTCCGGG TCTATAGTTC TCATGGTGGT TCAGAGTGGG CTGAATTGGG ATTGGAGTCT GGAATCCGCA 000880 000881 TCGTGGTTCT GAGTCCGCGC TATTGGGATG GAAGTTGGGA ATCCATGTTG TGGTTTTGAG TCAAAGCCCG AATTGGGACC 000960 000961 GGAGTCGGAA ATCCACTTAG TGGTTCTGAG TCAGGGCCCG AATTAGGATC GGAGGTGGGA ATCCCCGTTG TGGTTCTGAG 001040 001041 TTAGGTATCC TAGTTGGGAT CAGAATTCGG GTCTAGGGTC CACATCCTGG CTGGGAGTTT GCCTGAGTTG GGATCTGAGT 001120 001121 AGTTGGGGTC CCAGTCAGTC CGGGTCTGGA GTCCGCATGG TGGTTTTAGG TAGGGCCTCA TTAGGGACAG AGGATCGGGA 001200 001201 GTCTGAGTTG GGGACCTGAA TCCCGGTCTG GAGTCTGCAT CATGGCTCTG AGTTGAGATC CAAGGGAGGT CCGAGTTGGC 001280 001281 GACTGGAGTC AGGGTCTGGA GTCTGTCTTT GGGTAGAGGT TCTGAATGGG GGGCTCTGAG TTAAGAGATT GGGATTGGGG 001360 001361 TTAGAGGTCT CAGTGGGGTA TGGGAGTCAG GAATTGAAGT CGAAGTTCTG CCTCTAGGTG GGGATTCTGA GTCAGGAATT 001440 001441 AGGGGGCGAA GTAAAGGTTG CAGTCTGAGT TGGGGGTGGT GATCACCTGC CAGGTGAGAG GTAGTGGTAG AAGTCTCTTG 001520 001521 GTCATATTGG AGATGAGAGT TGATCAGATG CAGGTCTCAG TCTGGGTAGT AGGCTTGAAG GGCCACCACT ATGTTCAGAT 001600 001601 CCCAGTACCC CACTGTGGTC CCTGAGCAGG TCAAATAGCC TTTTATATAA AATTGAGAGT AAGAGTGCCT TCCCACAGCA 001680 001681 CTGTTCTGGT TATGAAAGAG AATAATTCAT CCAGGTAGAA TAGTTCTGTC TTAGATTATC ACAAAGTATA AAAACTTTCC 001760 001761 TGATAATATC CACATTTGAT GTGCATTTAC CAGTTCTTTC TTTACTGTGG TGCCCCTTTT GCTAGACCAA AAGCTCCCAA 001840 001841 CGAGGAACTC TGTTTTGTTT TCTGCTGCCT GCTCTGTACC CAGCCAAGAG CCTGATACAC AGCCTTACTC AGTCAGTACT 001920 001921 TGAAGGAAAG CAGGCAGGCA GGATTAACCA GATTTCTATG GTGTCTCAAA TGATCCATTT CTGCACCTGT TTTCCAGATA 002000 002001 CTCAGTAGGA GAAAAATTTA AGGATTGAGT TGCTTGATTA TGGGTGTATT TTAATGTGTT TCCTAACATG CTGAGGAGAA 002080 002081 AAGTGGGTCT GTTTCAGGAT TTATGCTCCA GCTAGAGGGA TTTTTTAAAA TTGCGAATCA GAGCATGTCC AAATTCAGAT 002160 002161 AGAAAGCACA AGAAAACTAT AAAGAATTTC CCTTATGAAT GTAGATGCAG AAGTTCCTTG TACAATGCTA GCTAACTGAA 002240 002241 TCCAATAATA TGTATTAAAC AACAATTCTT AAACAAGTGG GATTGCTCTT AGGAATGCAA AGATGATCCA ATATCAGAAA 002320 002321 CTTTATCCAT GTAATTCACA TTAAGAGGCT ACAGGAGAAA AACCATATGG TTCCCTCAAT AGAGGCAGAA AAAAATGATG 002400 002401 TGATAAAGTT TAACGCCTAT GTGTGATTTT GGGGTAGTGG AGTACACCAC TTAGCAAGCC AGGACTAGAG AGGAACTTCT 002480 002481 TCAACTTGAT ACAAGTTATA AACCAAAACT TAACTTTTCA GTAAACTTGA TAGAGAAATT AAAAGTGTAT CATTCTCTTT 002560 002561 AAGATAAGGA GTAGGCCAAG GATGTCATCC TGGCCATACC CTAATACAAG AAAAAGAAAT GGGGATGTGA GGATCAGGTA 002640 002641 GGAAGTGATA AAACTTAGTG TAGCTCATAG GGTTGATGGT CTCCATAAAG ATTCTCAAAC ATTTTGGTGT TACGACTTGT 002720 002721 TGTATTCTTA AAAGTTATTG AAACCCCCAA AGGGCTTTTC TTGATAGAGA TTCTATCTGT TGATAGTTAC CATCTTAGAA 002800 002801 GTTAAAACTA AGAAATGTTT AAAGCAGAAC TATACAAGCA CATATTCCAC TGGGGTCATG GTGTGCTGCC TCTGGAAAAC 002880 002881 TCTTTATCTT TGTGAGAATG AAAGAAAAGG CAAATAATGT CGAGTATTAT TATGAAAATG TTTTTGACCT TTCCTGAAAG 002960 002961 GGTCTGGGGG GCTCTCTGGA ATCCCCAGAC TACACTTTGA AAATTACTGG GCTACATGGA AAAAAAAAAT TAAGGAACTT 003040 003041 AACAACTAAA GAGAGATTTC AGATTTCAGA GAGGTTTTGG ATATAAGATC AGTGTACTCA AAACAAAAAA CAAAAACAAA 003120 003121 CCACATTTCT TTATGCCAAT AGCAACTGAC TAAAAAAAAG CATAATAGAG ATTAGGACAG CAATCAGAAT AGCAGCAAAA 003200 003201 TTTATACCAG TCTAGGAATT AACAAAGACG ACGACTTTTA TGGAAAAAAT TTTAAAACTC TATTGGAGGA TATAGAGGGA 003280 003281 GATCTTTCCA TATGCAGAGA CATTTTATTT TCTTGAACAG GGCAACTTGG CATTAGAATG ACGTCAGGAT TTTCCAAATC 003360 003361 TGTTAAGTTC AACAGGACTC CACTCAAACT TCCAGTTGGA GGGCTTGAGT AATTTAACAA ACATATTCTA AAATGTATGT 003440 003441 GGAAGAAAAA TATTTGTAAA TGCCAACTGA ACTTTTGAAA AGGAGAGCAG AGGACTTCTG CTGGCAGATA CCAGGGCACA 003520 003521 CGCCAACTTC AGCAATCAGA GCGGTGTGGT GACAGAGGCC CAGAAGAGAG CTCAGAGGTA ACTCCAAGTC TAGAGGAAGG 003600 003601 GGACATGTGA TAAAGGTGGC ACCACATATC AGTGGGGACT GTTCAGAAGA TGATGTTGGA AAGCCAGCCC TAAAATGGAG 003680 003681 GAATAGGAAT ATGGATTCCT AACTGAGCCC CTAGGAAAAG TAGACTCCAA ATGGACTAAA TATTTGAAAG CAAAAGGTAG 003760 003761 TTGCCATTTG TTTAATAGGA GAAAAAATGA ATAATCTCCA GGGCCAGGGT GGCCGTGGGG TTCTTAAACA GGATCCAGAA 003840 003841 AGCACAAACC TCAAGACTAA AATGTATGAA CTTGAATGCA TTAATGATTA TGGATTAAGG ATTTCTGTTA AATAAATCCA 003920 003921 TCATGGCAAG GGTCAAGACT GTTTTCATAA TAATACTAAG GAAACAATTT GCGTTTTTCA CTTTTACACT CATGAATGTA 004000 004001 ACTTTGCCAT GACTCATTAC AAGATATTTG AAACAATTAA AGCTGAGGAG GGAACAACAG CTAAAATATA CCAGAAAGCA 004080 004081 CCACAAATCA TTAAGAAAAA GGTAGGAAGA TTGCCAGTTT GCAGGAGGGT TAACAAACAG ATGAAAATTT GCCCAAGCTA 004160 004161 ATCAGTTATC AGAGAAATGT AAATGAAAGC AACAGCTATT CTTCATAGGA GAAGCATTAG AAAGTAGGAT AAGGCCAAGT 004240 004241 GTTGGCAGAA GGCAAGGAAC AAGCCTCCCT GTGTGCTGCA GGTGGGGACG GAGACAGGCA CAGACGTTCT GAAGAGCTGG 004320 004321 CCAACACTTC TTCCTCAAAT AAAATATTTT ATACCTGTGG CCCAGCAGTT TCCCTCCTAA GTAAACATGC TGGAGCAGTT 004400 004401 CTCACCCAGA ACAACGAGAG GCTGTGTGTG TGCATGCTCA GGGCAGCATG GCCCATAGGG GTGGGCAGTT GGAGCTGGTC 004480 004481 ACTGTGGTTA GGAGCAGGGG ACTAGATGTA CACTTCACAA GATAGAGACG CGTGGAAACA CAGTGCTGAG TGACACAAAT 004560 004561 GCCAAACAGA AAGAGGGCCT CAGTACATGA CTGTGTATTT AAATTAAAAT TACACACCAC CCAGACACGC AGTACTAGGG 004640 004641 AGTGCTCGTG AGTGCACACA CACACACACA ATGATATAAA TAAATTACCC TGGAGAAGCT GTTTGTGTAG GGAGGAGAGC 004720 004721 AAGGATAGAG GCTAGAGATG AAGTGGAAAA GCATGGAGAG GAAGAGAGCG GTGACTTTAT GCAGACCCTT ACAGGGTGAC 004800 004801 AGTGTTTCAT AGGCTGAGGG CTGTGATCAA CTCTGTGCAG AGTCCCAAAA GCCAAGAACC AACGAATGAA TGTGCCTCCA 004880 004881 TGACTCTCCT GCCAGATACC CTCTAGTGGC TTCTATTTCT AGGAAATAAA ATTCAAATTC CATCAGGTTT TTACAAGATC 004960 004961 TGCCCTGCTT ACCTCTCTGA CCACTGTCCT CCCTCACTGA GCTTTGGCTC TGCCAGCCTT CTTCTTCTTT GTTAAATCTG 005040 005041 CCAAGTATCC CTCCTGCCCC AAGGCCTTCA CCACCTCTGC CTGGCTTGTC TTTTCTGGTG ATCTTCCCTT GACAATTCCT 005120 005121 TCTTCTTATT TAAATCTCAC AGGAAATTTT GCTCTGACCT GCCATATCTG TCATCCCCTT CAGTCACTCA CTAGCTGACG 005200 005201 ACTACCTTTC GAGTCTCTGC AAAGCACAGG CTACGCTTTT CTAGTTCCTT AGACATCTAC TTATTTGTTG GCTGCCTATC 005280 005281 TCTTCCACCG GAAGAGAGGC CCCAAGAGAG CATATCTGTC TTCCGTATAG GGTCCGCACA TGGTGGGTGT GTCACAGATT 005360 005361 TCTGTTGAAT GGTTTCATTC ATTTATTGAA CGAAGGAAGA GGCCAGGCCA GGAAAGTGTG CCTCCATTTT CACAACTCAG 005440 005441 TGAGAAAGCA AATAGCATGT CAAAATCTGA CCCCTTGCAA CCAGGGTTTC TTAGCCAGCC ACACTGGTAA TGCTTGGGAC 005520 005521 AGGATGTATC TTTGTTGTGA GGGGCTGTCA TTTATATTGT AAGATGTTTA GCACCCTGCC TGGTCTCTAC CTAGTTGATA 005600 005601 TTAGTAATTC TCCCATAGTC ATGATAGCCA AAAATATCTC CAGACATTGC CATATGTCCC CTGGGGGGCA CCGCAGATGA 005680 005681 CAACCACTTC CTTAGAACAG CTCTTGGGAC TGGGATGGTG TCTCTGCTGT GGCTCTTTAA AGGCAGCAGG CCCTGGCTTG 005760 005761 CATCCTGCCA CATCTAACAC CTATAGCCTC ACCACCTCGG TGAGAAAGAC CCTGGCCCAG GCCTGGCCAA TCAGAGTACC 005840 005841 CTCTTCCCTG GTCAGCAGTA TAATTTGTTT GGCAAGCACT TCCAGTCCCA CAACCTATGG GCTGCCACCC AGAGGTTTAG 005920 005921 TTGGAACTAC GTGTCAGCTG CCGTCCCTCA GCCATCTATG GCATGGGCAC CTGTGGCTTG ACCAAGTTGG AGGTGGCCTA 006000 006001 GAGAGGCCGG GCTGGGCCTG CTCACCTTCT CCAGTTAGTG CAGACTGATG AATGAGTGGT TCTCAGCGGA TACCGGATCC 006080 006081 AGGTTTGCAG TACACTCCAG GAGGAGGACG AGTAGGGTTT CCCTCAGAGC AGGCCTGGAT GGGAGGGCAA GGGGTGGCCT 006160 006161 CTAATACTGC CTTTCCTTCC GGTGCCTTTA TCAGCCTGTG CCATGCTCCT CTGAACTGGC CGGCCCCAGC ATGTCCAGGT 006240 006241 TACTGGCAGG AGCCTGTATA ACCCAGGGTT CCAGTCACAC CAGCCAGGAA GGCCCATGAG GCTGGAGCGC ACCCAGTCTC 006320 006321 TGGCTGCTCT GTCTGCGGAA CTAAAAGCCT TTCTCCCAGA GCCTTTCCTA CGGCTGGGCG AAGCTCTTGT TTGCAATTTA 006400 006401 AATGTGGCCT CATTTATGGA AGAATCCCTG CTCCTCCGAA AAGCCTTGGG CTCAACCTCC CTAGCAGCCC GGGCCTCAGC 006480 006481 CAGGAGAAGA AATGGATCTA AAAGGCCTTT CTCCTGCTAA TTGTAGCAAT TAGCATTAGA GAATGGGGAC TCGATGGGGG 006560 006561 GCCAGCGCCT GGCAAAACAA GCTTATTCCC AGCTTAGGCC CAGGCCCAGC TCCACACACT GCTGCTTGGC CAGACTCGGC 006640 006641 CCCCACCCAG GGTCTGGTTG GCTTCAGGGC AGGGAGAGAG GGCCCAGGCC TGTGGGTGCT AAGAGCAGTT GTGGAGGGTG 006720 006721 TGCATCTGAG TTGTTAAGCC TGGTAGCTGT ACAGGTAGCC CTGGGCTATG ACTTGTGGTC CTCTCAGAAA AGGGTCTGAC 006800 006801 TGGAACGCAG AGCCAGACCA GATATTCATG AGTGGATCAC AGAGTGTAGA CTGAGGGCTA TCTGGTGATT GACAGAAAGT 006880 006881 AGTCTTGGGG CAAATGACTC TTAAAGAGTA AGGAGCCATT CCCCTCTATG GCTAACTGGA TGCCTTTCTC TCCCCCTGCT 006960 006961 CCAGAAAGGA CTTCCTGTTC CTTCACTGAG CGTGCTTGCT TATGAGGCTT CTGGAAACCA GGAGAGTTCA GTGGGCCTCA 007040 007041 TTATTGAGCG TATGGGCAGG ACAACCTGCT TGGGACATAG GCCATGCTAC AGTTGATTTT AGCCAGCTTG CTGCATCTAC 007120 007121 ACAGCACAGT GCCTTCCCAG GCAGTGAATT ATGTCTAACA GGCAGGGGAA TGATCATTGC CTCATGTTAG GGATGCAGTC 007200 007201 ATTCAAGAAA TATTTGTCAA ACACTCAGCA GGTACTAGAC CCTGGCCCAG AGGGAGGGAT TTGATAGGAG CAGGGACCTG 007280 007281 CCTACCCTCC CAGGGTTAGT GGACAAAGGG GAGAAAGACT AACTAATGTT GAAGGACCGT TTGCACCCTG AGGGGAGTGC 007360 007361 TGAGGCCTGG GAGCACAGCA GGTGTATAGC AGGAACCCAC TGGAACTAGC CTGGGGTCTG AAAAACTCCC TTGGGGAAAG 007440 007441 TGGCAGGGGC AGGCCAAGGG CCCTCTGGTG GTAGGGAGCC TGTGAGCACC TGGGATGGAA AGAAGCCAAG CATCTGAACT 007520 007521 ACCAGAAAGG CAGCTGCAGG ATTAAGCAAG ACCCACAGGT CTCTAAACTT TGAAAGGATG TCTGTCCACT GAGTAGATAA 007600 007601 TTGATTGGAA TGGGGCAGGG GATGTGAGAA TGCCAGTTAG GAGATGCCTG CAGTACAGAG AAATGGTGGC CTATCAGGAC 007680 007681 AGTGGCAATA GGGATGGAGG GAAGCAGGGA ACCTCTAGAA CTATGGATGG GTGAAGTAAG CCTGGCTTGG TGATGGGCTT 007760 007761 GAGGTGATGG GCAGGTGGTG AGGAAGCGGG TGTATCGGAA ATGACCCCAG AACTTCTGAC TTGTGCCACT GAAAGGATGG 007840 007841 GTGACACTGA AAGGACAGGG GCCTTCAGTA GAGTGGGCTA TAAAATGATG GAGGCTGTGG AGAGGAGGTG GGGGCAGGTG 007920 007921 ACTGGAATGT GGGTCTGGCT GGGTTGGAGA GACATTTGGG GGGTCAGGGC CTCACAGGTG GTCTGGAAGC CCTTGGTGCT 008000 008001 GAGGGAACAG CTTAGGGAAA TGGTTTGCAT AGAGAAAGGC ACTGGCATTT AGTGGCCATG CCAGAAGGGA AAACCTGCCA 008080 008081 AGGAGACTGA GGATAGAGCC AGAAAGATGG CAAGAAAGCC AGGAGAACTG GAGGGATGGA AAAGAGGACC TAGGGGTCAT 008160 008161 GGTCCTGGCA GAGGTCACAT TGGATCCAGT GCTTGTGATT CTCTGATTGC TGGCAGTGGA TGGCCACTGG CCTGCAAATG 008240 008241 GCCCTAGTGG AATGTCCCCT GCCTGTGTGG CTCCCTGTGG GCTGCCTCTC CCCTGGACAG ATGGGGAGAG ACCCCTTCCC 008320 008321 CACCTGGTTC TCTGTTTCAC CCTTGGAACT GTGGCGGTAA AGAGGACCTC CCCACAGTAC GTGCAGGGAA CAAGCTAGGT 008400 008401 TGACTCCCTC AGGGAGGCCT CGTCCTTGCT GAGGTATTTC ATAACCTCAG GATAGAGAAA TCCCCCCAAC TTTAATGCAA 008480 008481 AGCCAAGCAA GCTGAAAAAT GGCCTTGAAT AGGCTGAGAT GAAAAAACAA AGAGGCTGTC AACATCAGAG ACTCAGTGGG 008560 008561 GGCAGGGAGC TTCAGTGGAC TCCCCACAGA CAGCAGTTCC TGGGCTTCTA TGCCCAGACC CAGAGGCCTG AGCCCAAGAT 008640 008641 GTCAGGATGG GTGGTCACTG TAAGTGCAGT GGATTGTAGC TCAGGGGTGA GACATCGCCT TTTTCTTGTC AGCTCTCCTT 008720 008721 CCTGATTAGT GGCTCAAACA GCCTTCCGAG ACTCAAGGGG TTAACTGCAG ATCCTCTAAC TCCTCCACTT GCTAATTTTT 008800 008801 AAACACAGCT GAGCTCTGAG CACCCCTCCC AAGGCTGTGA GAGGCCAGAG GCCAGCACAG ACTCTGCACC AGGTCTGCAC 008880 008881 AGCCTCCACC CCTACTGTTG TCAGGAATCT GCAGGCATCT AGAACAAAGG TGCCTCCATT ATTTCCCTCA CCCAGCATAT 008960 008961 CCTGATACCT GAGCCAAGAG TTCACCCAGA GCTTTTGCCC ACTTCATTGA TGGTCTGGTG GGCTTTTGTT GACACATACC 009040 009041 CGTGACTCCC AAATGAACCT TTCAGGTTGG CTTAAAGCCG CTGGGACCTA CACATGACAA AACCCAGACG GAAACAGTGG 009120 009121 CTTACACTCC TGTGTCCCTA AAGGTACCTG TTCCTAACAG TGGGAGTGCC AGAGCCTGGA AGCTGGAAGC CAAGGAGACA 009200 009201 GGGACCTCCC TCCTGCTGAC CCCCTGCCAG GCCACATCCA CCTAAGGGAT TTGGGATCAT ACTCCATCTT CAACCACTGG 009280 009281 GATCAAATGG AAAGCCCTCA GGAATTCTGA GAGACAGCCC CTATACCTAT GTGCACTGAC ACACATACAC TGACAAATAC 009360 009361 GCATTCTGAC ACATATATGA ACATGCACAT ATGTGTGCCC CACTCCCTGC CAGGAGGTGG GTTCTGTCCC ATCTTTGACA 009440 009441 TGTTACTTCT TGTCCTTCCC TAGGCCCAGT GGCACTTTCT TTGTGATAGG TGCTGAGACC CCCCCGACTG GGCCCAGTGG 009520 009521 CTGTTCCCAG GACCCAGTCT CTGCTCTTAT CTTAACCCAG CTCTAGCTCC CAGGACCCCA GCCTTTCGCA GGGAGAGAGA 009600 009601 TAGCTCTTTT GGTCTGGCAC ATGTTCCATG CCAAGTAGTG GAAACAGCAG CTGCAGGGCA GCCTCAGACT TGACATCATT 009680 009681 TAATCCTTGT GACAATCCTA CAGGGAGGAA GACACTACAC ATATGTGCAG ATGCAGCAAG GAGCAGCTCA GCCACATGGA 009760 009761 ATGACTTGCT TGAGGTCACC AGGCACTTGA CACAGCAGAG TTTAGCCCAG TCTCTGGAGA GACCAGCCTT CCACATCCTG 009840 009841 TCATGCTGGG GAGGGCTGCC CGCTTTTTGT CCCTGCTCCC CCAGTTCTAA CCCCGGAAGA GCGATTGTCC CTGCTGTGCC 009920 009921 TTCAGCCCAG ACAGAAGCAG GCTAGGAGAG GGGAGGAGAG GCAGGGCTGG CCCTCGGAAG GCTCACCTTC CTCAACAGTT 010000 010001 CTCTGCTTGG GCAAAGGTCT TCCAAGCAGC CAGGCTCTGA GGCTAGTCAC TGTCATCGTT GGGTGAGGCA GCCTGGGAGT 010080 010081 ACCAGAAGTT GGAGCAGGTG GGAACCTTCC CCAGGGATGG GGCTGGATAG GCAGGGGTGG GTGCTAAGTG GCAGGCCACA 010160 010161 ACCAGGCACC TGGGAGGGCC AAGCACCACA CTGAGAACGC AGTGCTTCCC CTCCCCTCCT AGGCTGCTCA GGAACCCATC 010240 010241 AGTCTCCTGT AAACAAATGA GACTAAGTCT CTGGCACTCT AGGCCCAGGT GCAAAGGACA GCTGCCCCTG CAGCTACTCA 010320 010321 CTCTGCCCTG GCCCTCTCAG GAGGCTTGTG ACCTCTGCAC CTGCTGGCTT GTTTTGTTCC TAAAATACCC GGATCCTTGA 010400 010401 GAATCTAGAA GACACCACTG CTAACAGATT TCCACATCAT TCATTCTGTT CTTCCTGTGC AAGCTTCATG CTGGGACAGG 010480 010481 GACCATAAAA CAAGGTGACC CAAAACCTTC AGCAGAATGC AGGTAGGCAG AGCAGAGGTC TCTGGGAGTG TCATTCCAAG 010560 010561 GCAGTGTCTT CCTCCTCCCC TATGCTCCCC ATTTCCCAAG AGTGGGCTTC TTCCACCCCA CTCAAGCACC TCTTCCCAAG 010640 010641 GCTGACCTAA AGGCCTCAAG CTCTGCGGAT AGGGGCAGTC CTGAGGTGGC ATTGAGTCTT AGGGTTGGAG TGGGAGATAT 010720 010721 CTGTGCAAAG GCTGATAGGA ACGTCCTCCA AGGGCTGACT TCAAAGCTTG GCCTAAACCA CTGCATCAAA GTCAGCAAGC 010800 010801 TGAGCTGTTT GCACAGAAAA GGAGGAGGAG CAGGCCCTTG AGCCACCTGT AGCTCTCCTT AGGGTCTCAG GCTTTCACAC 010880 010881 CAGGGCAGGC CTTGGGCCAG ACTACCCAAC TTCCAGGCCG GATGTGCCAC CGGGGAGGAG GAGGTAACTG CCCCTCAAAA 010960 010961 CCCTGCAGCC CAGGGCTCCA GGATTCCAAC CCAGGGACCT GCAGGCTCCC CTGCTCTCCA GATCAGACCC CTACTCTCAG 011040 011041 AGCCCTAGGC CCAGTGGGTG ACAGCCTGTG AGACAGGCCT GTGTGGGGTG GCCCTAGCCC CACCTCAGCT TCCAACCTGA 011120 011121 CCTTGCTGCA TGACCTCTGG CCCAGCCCTC TCCACCTGGA GTGCCATCTC TCTTTGTGGG ATGGGCCAGG TGGGCTGTGT 011200 011201 GTGGGGGAGG GCAAGTATAT AGGTGTGGTA TAGGTGGAAA CTGCCACAGT AACCAGCAGC AGCTCAGAGC CGGGCCACCC 011280 011281 AATTTGTATG CCAGCCCCAG CTGGGCCTAG GCACGTGGTG TGTGGAAATG AACGAAGCAG GCAGCCCTAT GTTTAGGAGG 011360 011361 CAGGTCCAGA GCTCACCCAG GCACAGCACA AGATGAGTGC CTGGCCTCAG TGAGCGAGCA CTGGCTGCTA TGAGGCTGTG 011440 011441 GTGTGGAACC TTGACACTAG GGCCACTGGC CTGGCTGTGT GACCTCTACC TCATCACCCA GAGCAGGGCA ACCAGAGGCA 011520 011521 GAGCCTCAGT GTGGTGTTCT CCTGTGAAAT AGTGATGGCA CAGGCAGGGG CTGGGGCCCA GTGCCTACAC AGAGGATCAG 011600 011601 CAAAGGATGG CAGTTATTGA AACCTCTACG GGGAAGTTCC CCAGACACGA GAGGAAGACC CCCATGGAAG CTGTGTGTGT 011680 011681 GACGTGCTTA GATTTTCCAG AGTCTTCATT TTCCTTGTCT AAACAGAGGT CATGGCGCCT CCCTCTCAGA TCAAACAGCC 011760 011761 CTGTATGAGT GGCTACAACC TTTGGTGGGC TCAGTGCAGC CCCTCCTGCC CCCTTGCTTG GGAGCTGTCT GCAGAGGCCT 011840 011841 AGGGAGCTGC GTGGGGTCTC TCCACCTCAG CCTGTATCCC CACCCCCACC AGGTCCCCTG CCTGACTCCA GCATACCCAG 011920 011921 GCCCTAGAAG CACCAACTCC ATGGCTGCAG CTGAGTGGAG TGTGTGCCTG CCCAAGCCTA GAGGGGTGCT GACCCCTCCC 012000 012001 TCGCACGAGG AGACATCAAA GGGAAGCAGG AAGCAGCGGC CTGGCTGACC CACAGCGGGT GGGAGAAGTG CAGCCTCACA 012080 012081 ACTGCTGGGG ATTTTCCATC CCACCAGGAT TTCCGCGGGA CACCCCAAGT CCAGCCTTTG AGGCTCCTCA GGAACCAGAG 012160 012161 TTTGGCCTGG AGCCAGTTGG GGCAGAGGAG GGGGGCCAGG CTGGGTGGCT TAGGGGTGTG GTTAGGCCTG CTAAGGGGCT 012240 012241 CCTCTTCTCA GTCTCCCCAT GATTTGCTGG TTACTGGCTT GAAATCTGGG CCCAGACCCA TTCCAACACT GAACCCTGAG 012320 012321 CTCCCTGAGA CCTGGCTGGC AAGGACAGGT CCCAATTTTT ACAGGGGCCT GAGAGGAATG GAGAAGGGAT CTCTGCCCCT 012400 012401 TCCTTTCTCA GTCACACCTC CTTGACAGGG GGTCATCAGA GTGGGCTGTG GTAGGTGCAC CAGGGAAGGG ACCATACAGA 012480 012481 GGAGGCTGGT CTCAAGTCCT AGGGTGCCTG GGATGGCCCT ATTGAAATGC TGCAGCAGCT CTTGTGCAGG CAGGGATCTG 012560 012561 TATGGACAGC TGGGTGGACA CAGGTGCCTA CTGACCTCCC AGATCCTTCA GCAGAGCTCA GCCCTGAGTG ACAGCCCAAG 012640 012641 GCAGACCTGG CTACCTCAGC CTCTGGCTCA CAGCCCTCAG CCAGAGCCCT GAGAGGCCTG GGATCTCAAA GCTGCAAGGT 012720 012721 GGGAGGCCAG AGGAGAGAAG CCCGGAGCTG GTAGTGATGC TGGCTGAGTG AAAATTGCAC ATTTCCCAAC AGTGTGATGC 012800 012801 TCCCTATCCA GCCTGGGCTT TTGGCAGACT TCTGTGCTTT GTGGAGGAAG CTGGCTCAGA TTCCTCCCCT CCCTGTGCAG 012880 012881 TTTGTGTGTC AAGGTGTACT TGTCACACCC AACTCAGGAT ATCTTGCATC ACTTTGTGGG TCCTTGTCCC CCAGAGCTGG 012960 012961 GACTGCTGAG TTTTAGCCCT AAGCTCTTGC TCCCATCTTA GCAAGTCAGG GCCCAGTGTT GTCCTTGCCT CTGCATCAGG 013040 013041 ATGGTAAGCT GGGCATGCTC CGCATCACGG AGACCTGCAT GGACCTGGAT TGGGTTGCCT CTATCTTCAG GCTGGTCACT 013120 013121 GGGCAGACAC AAACCAGGGC CTCTGGCCAG AGGGGACAGT GGCTCTGAGT TACTTGTGCT GCTCTTTAGG GGTGAGCAGG 013200 013201 GGCTGCTTGT GCATCATAGT GTATCACAGG GGATGCACAT TTACAATTGA AAGCTACTGG TCCTGGGTAG AAGTGGGGCC 013280 013281 GAGTAGGACT TCCCAGCCTT GAACATGGGT TTGTCATCCA ACTGGGACCC ACACTTGATC CAGCGGCCAT GCTCTGTGCA 013360 013361 GCCTGGGCCT GAGGGCAGCC ACGCTCATGT GAAAAGTGCT AGTAGCCAAG CTGCCATTCT AGTCACCACA GCTGTCCTTG 013440 013441 CAGGAGCACA TTGCCCAGGG CTGGGAGCTG TCATTTCCGT GACGGGAGTG AGACTCAACA CTGGGTGAGG GTGGGGGTAT 013520 013521 CTGTTGGGAA TTATTTCAAA ACAATTGTGG AAACTTGGCA GTGGAGGGGC TCTGGGCATA GGTATCCACA ATATCCTAGT 013600 013601 CAGGGGTTGG GGTACCCTGG CTCTGCTGAT AAGCCCAAGT GAGCATACTC CTCCCCCAGC TTGGAACAGG TGGGACGGGC 013680 013681 CAGGTGACAC TAGTGTGGTC TGTGGTCTGG CCTCCCAAGC CAGTGGCAGT ACTGGGGTGG CAGACATTTG CTGTGTGCTA 013760 013761 TCCCAAGGCC TAAAGGTCAC ACAGCTAGGT TGGAGCAGGG TTTTGGGCAG GATGAGTAGG CATTGCTGTG CTCTCAGAAA 013840 013841 GGCGAAGCAA ACCCCAGAAG CAAGGGGGCG AGACAGGGCA AAGGCCTACA CTTTGCCATC AACTCAGGCC TACTCAATGC 013920 013921 TGGCCCTGTC CTTCCCCTGC CCCTGCCCCA TCAGATGGTG CGAGCTGGCG GGGCTTAGAG TGAGCCCCCC TGACTCTTCT 014000 014001 TGGTGTGGAG TCTGAGGCCC AGAGTGTACA GGCCTCATCC GTGTGACCCA GCAGGAGGAT GGGAGAGTGG GCCCAGAACT 014080 014081 TGGTCAGGCT CATCCGTGGA GAACAAGTTC TTCCCTAGTC TAGTTGTGGT CTGAGTCCTG GGTGAAGCAG GAGGCAGCCT 014160 014161 GGGAAACAGC CTCGTTCTAG TAGGAATCGC ATTCTCAGGA ACGCTGACTG TGCAGGGCCC TTTCTCACTG CCACCTGGGA 014240 014241 GGATGCCTGC CTGCTGGCCA TTTCGGCGGA CTGTCAGAGC ACCCTCCCTG GGGTCCCAGA CCGAAGGCCT GAAGTCCACA 014320 014321 TGGGACCCCT GAACTTCTGG TACCTGTGTG GGCTTGTCCC CTCAACCCTG AGTGGAATGG CAACAGCCAG CTGCAACCCT 014400 014401 CCTAGCTTCC TGTCATGTGC TGTATGGAAG GGCCAAGAGC TGTAGTCATC TGCAGATCCT CCCACTGCAC CTGTAGGACT 014480 014481 AGCGTCTCCT GTCTGGATGT GAGCAACTTG CTGGTGGCCT GTGAGATGGG AGTTGCACTG GGCTTCTGGA TAAGGGCTTC 014560 014561 TCGTTCAGGT GACAATTCTA TGTGAAGGAG ACCCATGGAA ACACATCTAT CCCCTGCCCA TGTACCAGGC AGAGATGGTA 014640 014641 CCTGCCCATG TACCCTCCAT GACATGGCTG GGTCCCTGAA ACATCAGACA GATCGATACT CTGTGTGCAT GTTTGTGGGC 014720 014721 AAGACACAGT GGCACGTGTG CCCTGGAGTT TGGTAATGGG AGGACTGAAG TAGTGCCTCC GTGTGTGAGC TGTGCCAGCC 014800 014801 ATCCCCACGA AGGGGGCATT CCATGCAGAT GGGGATCCTC TCCAGGCAGC TTCTTCCACA CCTGATTAGC TCTGACCATC 014880 014881 AGACCCCCCG TGCCAAAAGG GCCCCTTCCC TGGAATCTGT AATTCTCACA GGCTGTCCCA TACATTTTAA ATCCAGGAAA 014960 014961 TGTGCTCACC CATGAGACAG GGATGGCAAG AAGATATGAA TGAAAAGCAA CCAGTCCGTA AAATTGGAAG CCATTTCACT 015040 015041 CCTTACCAGG TACAAAGATA ACATGCTGCA TGGATCAGGG ACACAAACTT ACCTACCTTA TGATGTAGTG AAAGAATCTA 015120 015121 AAACTTTTGT CTCAGCAGAC TCCCTGGAGG AAGCCAATAA CAGGAGGCCT TGACTAGGAG ACCTCAAGCC TTGGAATGTG 015200 015201 CCCAGACCAG TGGGGAGGGA AGGCTGGGAG GCAGTCCTCC CTTACCCCTT TTCTCCCAGG CAGACCTACC CTGGGTTCTC 015280 015281 TCCAGGCCCC TCCGCCTGAG CAAGTGCTCA GTTGGCCACT AGCTCCCTGC ACATCCAACA AGCCTTTCTT TCCTGTTCCT 015360 015361 TCTTCAAGGA AGGCTTAGCC TCAAATCCAG GGCCACAGAC AAAGGACAGT CACTCTCCTC TGCCAGAAAG TCATTTATGG 015440 015441 GACATGGAGA AAGCATCAAA TATATTGCTT TTCCAACACC TAACAGTGGA ATAGGAGGAA TAGAAGGAGA ACTCAGCCAG 015520 015521 AAAGTTCTGG AGCATAGTCT TTTTGCCAAA AGAACACGTT TTCAAATGAA AGAGGTGGTG CTGGGGCACT GAGGAATCAG 015600 015601 GGGGATGGAC CCCACTGGAG CTTGTCTCAT GCTGGCAGCA AGTCCCAGGC CTCAAACACA TACCTGGGCC ACCTCAGGAG 015680 015681 AGAGACTGCA GGGAAGAAAT GAGTTGCAAT GCTCCAGCCT AACCAACTCC CCTTTTGTTA ATCCAATCCC AGAAGGTACT 015760 015761 GGGTAGGGTC AGTTAACAGA CAGCTGCCTG TCTCCTGGCA GAGTCTGACC AAGCCCCAGT GGGCGCTTCT CTTCCTAAGT 015840 015841 CCTCTGGTGT ACCCCATTCT TCAAGGGAAA CGGTCCCCTT AAGAATCTAT GTGAAAGGGT TCTGAAATTG CTGTACCAGT 015920 015921 TAATGAATTA TTTACTCTAA ACAATGTCTT GATAAAGGGG GAGGATGAAG TTAGCTGATG TTGACTAAGG AGAGACGGAG 016000 016001 TTGCCAAGGA AATTCTTCTA AATGAAAAAA AAAAAAAAGT AAAAGCAGTC AGCTGGTTTT GTCTGACTAT GAAACGTGTC 016080 016081 ACAGAGCATG CACCTTTGGC CATCTTTTGC ATTTATGATT TGGAAGAGAG ATGTAGCAGT GAGTGTGGGG CCAGGGAGGG 016160 016161 GAATCCAACA AAGCCATTCT GCAAGCTAGT GGCTGGGATT TTGGGGTATA GAGTAAGAGC AGCCAGCCTT AGAGGCCCAT 016240 016241 GTCATCTGGG CTGCCTCAGA GCTAAAGCTA GGTAACCAGA GGGAGTAAGG AAAGGCCTGA GTCCCAGGCT AGGCTTTTCA 016320 016321 CAGTTGTATT GAGATGGGAA AGTAAGGGAT GTTCCTTGCA GCAGATGCAG GGCCCAGTTG TCTAGAGCAG TATTTGAAAT 016400 016401 GAGTTGGCAT TTCAGGGCAG TGTTTGTGAT GCCAGTCAGT AGGTAGGGGC TTCTACCTCT TTTTTAGAAA TGTTTACTCT 016480 016481 GAACTAAGCT CTATGCTTTA ACAAGTTATG TTTTAATAGG AAAACTGTCA TTGATGGAAT CATATGTAAT TCCTACATTT 016560 016561 TTCCAGTTAC CCATTCCTGG GGAAAGCTTA GCCATTGGAC AAACCACCCA GAGCCCCAGG AACCTGCATT TGCAGACAGC 016640 016641 AGTGGCAGGC ACAGTGGCCT AGTGTTGAGC GGGGGAAACC TGGCCTCTAT GTGTCTGGTT TTGCAAACTA AAACGCCATT 016720 016721 GCCCATACTC AGGCTGACAG GTTCTGGAGG TGCCATGGAC TCCTGCTCTG TATCTCACCT CTAGTTCCAT CACAATGCAT 016800 016801 GAGCTGTCAG TGGGAGCCTT TTAATGCAGA TGCTAATACC CATTCCTAAT GCTAGCCCAT CCCCACACCC TCCTGAGTTG 016880 016881 GTGCGATATA TCCTGGGAAC AAGAAAATCT GAAGGCTCCT GGTCCTCAGG CTAGCAAGAG CCTTGCCTGT AAGAAGTGGG 016960 016961 AGAAGGTCAC CTCTCTCAGG AGGCAGAACT AAGGCTGCAC AGCACAAGGG AGATGTCTGA ATGCACAGTC TGGGTGGCAG 017040 017041 AAGGACTCCT GTCCTTTCTT CCACACAGAC CTGAGCACCT CTCCAGGTGC CACCATTTTC TGTCTGGGAA CATCTGCTAT 017120 017121 CCCCAAGCCT CAGTTTCCTG GTCTACAAAA CTGAGATGGT CTCTTCTATA CAAGGCCCCA GGAGGATCAC TGCAAGTCAC 017200 017201 TGCATTTCAT GGTGCCCAGA TTTCCCTGCA TTTCTAGAAT GTCAACAGAG ATGAGTGGGC TCAAGGGGAA GAGATTCTTT 017280 017281 ATGACTAGAG ATATTCTGGT CAACTTTGGA CCCCAGCTTC TATGGACAAT AGCATGTGGA CATGAGCCCT GGGGAAGCAG 017360 017361 GGATGACTGA GCCTGAAGAA GAGCTCTCAA GCCTTACACT CTCCAGACCA GCCTTGGGTT GCCTGAACCC CAGCATAGCC 017440 017441 TTATGGAACC CCTGCCAGGG TCCTAGCACC TGGTTTGACC TGGGCACAAG TACTCACTCA CTCACTCACT CACTCACTCA 017520 017521 CTCGTCAAAC ATTCACTGAG GGTCCGTGAC AGGCTCCATA TGGATTAAGC ACTGAAGATA AAACACTGAA TAGAAACAGC 017600 017601 CAGCCTATAC CCTCATGCTC CTTGAATGTG ATAGAAGGAG CCAGCCAGTA AACCCTTTAC CACAAATAAA CACACAGTTA 017680 017681 CACATTAAGA ATGGGAGGGG AGGTATGTGA TTTTTTACAG CCCAGTCTTA AGCTTTAGAA ATTGGCTCCT CTGAGGAAGG 017760 017761 GACATTTCAG CTAAGAACCA CAGGATAAGA CAGTCCTGGC CTGGGGAAGG GGAGAGAAGG TCAGGAGAGA GCTTGATATG 017840 017841 TTTAATACTG AAAGAATATT TGATGAGCTG GGACATCTCC TGCAGATCCA CGGCTCCCTA GCTTTGTGAC CCTGGGCCCT 017920 017921 AGACTCAATC CCTCAACCCT TAGGAGATTA TCTATAAAAC AGGAGTGATA ATATTCTTGT GTTAAAAGCT GCTGTGAGGA 018000 018001 TTAGTGAAAT GATGTCTATA TTTGCCTGGC AAACAGGAAG TGTAAGTAGT AGTATCATTT GAAGATTATT CTTCAGCCTA 018080 018081 AACGTGTGTT CATTATGGCC GGTGTGTTTT CTCCCCACCT AGATGGTAGT GCTGGGCCTC CTTTGGAGTA CCTTGATGTT 018160 018161 TGGGGAGCAT GGATGATATG ACCATAACCT GAGAAGGCAG GGACTGTACC CATTCTGGTC CTCCCAGGTC CCAGGGCCCC 018240 018241 CACAGTGCCC TGGTGTGTGA TCAGTGCCCA CAATACTGAA TAGAGGAACA GACACATGGG AAGCAACGGC AGCCTGGTCT 018320 018321 TTAAGGGTGA GGGAGCACCT TCTCCTGAGA GAGGGAGAGA TAGGTTGGGG GAGGTTGGGT GGGGGTGGGG AGAGCGAGTG 018400 018401 AGCAAGCAAG CTAGAAACTT CCTGAAAAGG GAAGTTACTC TAGAAAAGGG TAAGTTCCTT CCAGGCATCA TGGGCTGGCT 018480 018481 TAACCTGGAC CAGTTTGACT TTACTAAGTC CCATTTCTCA TCTAGGGAGC CTGAGGCCAT TAAGGTTATC TGGTCCCAAA 018560 018561 ATCCCCTAGA GCTGTCACAG GGATCCCCAT TCTTTGCCTT TAGTCACCCC AGCCCCAAGA GCCATCCTCC ACATGGAGTG 018640 018641 AGCAGGGAGC TACAAGGAAA AGACGGTCAC AGTTGGAGAG AGACAGAGAA CCAGGTGGGC TGGTAGGACA GGAAGGTATA 018720 018721 GGGAGAAAGT GAAGCTCTCT CCTGGGGAGG CAGGAATACT CTCCTGCTTC CTTCTACCCA CTCTTCATAG AACACAAACA 018800 018801 CTGCAAAAAT GACTTTTTCC AAACCCTCTT AGCATTCAGA AGTAGAATTG CTATGTAAGA ATTTTTTCAT AGGTGCTTTT 018880 018881 TTGGGGGGCA TCTATTTAAA AAATAACCAC ATCATTAGTG AAATCTTCCA AAGTCTCTTT TTGGAGCCCA CATTTCACTA 018960 018961 ATGTCCACAT CTGAGGAGGC TTTCATAATA AAAGAACACA TACCTATTTC ACCTATGATG GTCAGTGCAA TCTTGAAAAC 019040 019041 ACTAGTAAAT AGTGTCCATC AGCTTTAAAA ATACAAACCC AAATTGGGTC ATACCAAAAT GCAAGGATAC ACACAATAAC 019120 019121 CTGGGTGAAT CTTCAGGGAA TTGTGCTGAG TGAAAAGAGC CGATCCCAAA AAGGTGATTT GCTATGTGGT TCCATTTATA 019200 019201 TAATTTTCTT GGAATGATAA AGAAATGAAG AATAGGTTAG TAGTTGTCAG GGGCTAAGGA CAGGGTAGGG TGGGAGGGAA 019280 019281 TTGGGGGTAG CTATAAAAGG GGGACATGAG GGATTCTTGA AGAGTTAGAA ATGTCCTGTA GTGAGACTAT CAATGCAATA 019360 019361 TCCTGGTCAG AATATTGTAC TACAGTTTTG CAAGATGTTA CTATCGGGGG AGACTAGGTA AAGGAGTATG TAAGATTTCT 019440 019441 CTGTGTTGTT TCTTAGAACT GCATGAGAAA TGTACAATTA TCTCAAAATA AAAATTTATT TTAAAAAATG CCCAAATTAA 019520 019521 AAAAAAATCA GTAGTCCTCC TAAAAATACC CAGAAATGAA TTTTAGAATG TCCAAAATCC ATACAAAGAT CTAAAAAAAT 019600 019601 ATGGAAGGAT GTTGCAATGG ATTTGAACAT GTGGGTAAAC TGCTTCTATT TGTGGCTGGA AAGACTTTTT TTTTGAGGTG 019680 019681 GGGAAGGCAA TTCTTCATCA GTTAATCTAA ATTGAATGAA GTTTCAATAA CAAATGCCAA TGGGATATGA ATATACACAC 019760 019761 AGATAGACAA CTTTTTTTTT TTTTTTTTTT TTAATTAGGC AAGCTGAGGC CAGGTGCATT GGCTCACGCC CGTAATCCCA 019840 019841 GCACTTTAGG AGGCTGAGGC GGGCAGATCA CTTGAGGTCA GGAGTTTGAG ACCAGCCTGG CCAACATGGT GAAACCCTGT 019920 019921 CTCTAATAAA AAAAAAAATT AGCCAGTCAT GGTGGCAGAT GTCTGTAGTC CCAGCTACTA GGGAGGCTAA GGCAGGAGAA 020000 020001 TTGCTTGAAC CCAGGAGGTA GAGGTTGCAG TAAGCCGAGA CTGTGCCACT GCATTCCCGC CTAGGTGACA AAGTGAGACT 020080 020081 CTGCCTCAAA AAAAATAAAA ATAAAAAAAA AATTAGGCGT GCTAGTTCTA AGTTTATATG AAAAAAATGC ATGTCCTATA 020160 020161 AAATTCAGAA GTAGCAGCAG TCTGGCCCCT TGTGCTCCTC TAGCCCTCAA CTGGCCTAAC AGGCCCTAGT GTGCAGCAGG 020240 020241 GACTATTTTC CCATCATCAC TGTCCACAGC ATCTGGACAA GAATACAGAG AACGGCTGAT TTAAAAAAAA TCTAATCTGG 020320 020321 GATCCTATGC ATCCTAAATA ATCTTATGAG GATGCACTTG TATTTTTTCT GATGCTGATA CTATTCATTC CAACTCGCCT 020400 020401 CCCCATCAGC TTTGTCAGGC ACTGTGAATT GCATGGTACA CATGATTACA ATGGATGGAA TGGCCATCAT GAGGTATAGC 020480 020481 AATACATTTA AGTAACACTG TGTCACTACT ATAGGACAGG CACTTTTCTG CATACTTTAT ATTATTAATT TGTGTAATCC 020560 020561 TCCTAACAAC CCTCTGAGGA AGGTACTCTT ATGATTCCCA TTTTACAAAT AAAGAAACTG AGACTAAGTG ACTCACTCAA 020640 020641 GGTGTAGCAG GTAGAAAGTA GTGGAATTAG GATATGAGTT CAGACTCCAG ACCCTGTTAT TAGCCCCTGT CTTTGGCTAT 020720 020721 GGATTAGTAA AGGAGAGCAC AGCCAAGGGT GGGACAGGCA GCTGTAGTCC TCTGGACCAG CTTCACATGG ATGGGGCTGC 020800 020801 ATTGTTACAG GTGGCCTAAC TCAGACATGG AAACTGAGTC GCTGCTGCCC AACTCATGCC ATGAAACCAT TTTGGCCTGC 020880 020881 ACAGCTTATA ACAGCACTCT AGCTCTAGCT ATGACACTTT ATGGTGTTAG TGGGTTTTTT TGGTGGTTGG TATGGAGGAG 020960 020961 GGGCTGGGCT ACAAGTTTTA GATTATGTTT CTTATTGCGG GTTTTTAAAA ATTCTTGAAT TAGGCCTATT TGCTCTTTTG 021040 021041 TTCTCTATTG AGTTAGCAAA TTCAGTTTTT CCAAGATGCC CTGAAAGTAT GATCATACAT GTATACGAAA TGGTCCTTGG 021120 021121 GTCCAGCTGG CAACTCCTGT GCACCCCCGA CCTGGATTCT GCCTTCCTTG AAGTGAGCCT TGGAAGAAAC AAGTGCTCAT 021200 021201 GCTCCCTGAC ATTATTAGCT GCCACGATGA AGCCTCAGTC CCAAACACCC CAGCTTCCTG TCTAACTCAA GAGCTAATCC 021280 021281 TGTGTTTAAA TCTTAAGAGT GTTTAGATCT TAGGCCATGC CATGAATTCC CCTGGTTGAC TGCATTTGTG AAAATGAGCT 021360 021361 TCCCATTATT GGCTCTTAAG TAATGGAGAT GAGGGGGAGT CCTGCTACAC AGATAAGTGC ATCATAAAGT TACATAATTA 021440 021441 AAATAACTGA GCTCTGGCCT ATCAACAGGC CCATCAGCAG TCCAGAATAG AGTCTAGAAA TGGACACAAA TTAAATGAGA 021520 021521 GTTTGAAATA TGATAAAGGT AGCAGTTGAA ATTAGTAGAG AGATGATGAT GTACTCAAAT AAATAGTGTT GGACAACTGG 021600 021601 ACAAATATAT GGGAAACCAA ATTGGATTTA ATTACTCTGT CAAAATCCCG ATAAAGCAAG GATTTAAATG TAAAAAATGA 021680 021681 AATAAAAAAT GATAGAAGAA AACATGGAAG AATTTATTAA AACAATTTCA GGATGAGAGG TTATTTCAGA ATTTAAGATA 021760 021761 AGGACCTCAA ACCATAAAAG ACTGACACAG CTGACTATGT GAAATTAAAA AAATTCTGCC ACCAGAAAAA TATTATAGAA 021840 021841 AAAGCCAAAA CACCTAAGGA AAATGAGGAT AAAATATTTT CAATGAATAT GACAAAGCAA GTTTCTACAA ATCAGTAAGA 021920 021921 CAAGGTATTT TACAAAGTCC AAAGGGTATG AAGAAATAGT TCACAAGAAA GAAAAACAAA TGATTTTAAG CATTTGGAAA 022000 022001 GATAAAAACC TCATTTCCAA CAAAAGAAAT GTAAATTAAA GCTCCAGTGT ACCATTTCTC ATCTATGAAA TGAATGAAGA 022080 022081 TAAAAACCTG AGTATACACT TGGTAAGGGT GGGGGAAGAA AGTGCATTTG TGCAGTCAAA GTGATGTAAA TGGTACAGCC 022160 022161 CTTATTTGGC AGTATCTATC ACAACATAAA TGAACATTTT AATCCTGCTG GAAATGGGGG GAAAGGGAGG ATCTCTTAAA 022240 022241 GTAAATCCAC TGAAAACGGA GACCAAAATT TTACAATAGA GATATTTGAT TGGGAAGTTA ATTTGAAAAA TAACAGTAGT 022320 022321 TAAAATATTA TTTTATCTCA TATGCAATAA CAGTTGTTAG AGTTACAATT ATGTACACGT TTTAGAAAAA AACAAATCCA 022400 022401 GAGGGGATTT TGGTTTGTCT TTTGTAAAGC ATTATATGGT AACATCTGAG GGCATCTTTT ATACTTGGCA GAGGATGTTG 022480 022481 GCAGCACTTC CACAGAGAGG ATCATTTTTT GTAGAAGTAT GGCATGGTTT CACTGCTTGA CCAAGAGGCC ACCTGCATCA 022560 022561 ATTATCATCT CCCCTGCTGT CCTCTGAAAT GCTTATCTAG GCATCGATCT TGGTTTCCTC TTCAACTGAT TAACTAACTG 022640 022641 GTCTACTCTG CCCAGTCTCT ATTTGAGAAA TCATTTGACA TCATTTTCTT TAACTTGATG AAATCTCCTA TTTTGACAAG 022720 022721 ATTTACAGTT CCTCTTTATA AGTTCCTCTT TACTTTGTGT GTGCTTTATA TTGTCTTTGG TTGACAAGAG ACAGCCAAAG 022800 022801 AGGTCAGTCA GCAGAGATAC AAGTAGGGAT AAGATGGATA GGGAGAAACA ACAGTGTTCA ATAGGGAGGG ATGTTTCAGG 022880 022881 GAAACTAATT TCATAAGTGG TCATTTCAGT AGTGAATATA TTTGAATGGT TAATGGCTGC TGTTTTTTAG CTGCCCTACA 022960 022961 TATCCATCAA CAGAGGATCT GTTCCATAAA TCATGGCACA ATGAAACTCT GCAGCTGTTA ATGAAAAGGA GATTTGCTAG 023040 023041 ATGTCTTAAT ACAGATCCAT CTCCAGAACA TACCAGTGTC TTCCTTTTAA GTGGTGCACA CTGGGGCTGA ACACTTACTA 023120 023121 AGAAATGAAA GGGCTCCCCA GTCAAAGCTG ACAGGTGTCA TTACAACATG ACCCCTGTGG TAGATCCCAG CACAATACAC 023200 023201 TGGCCATCAC TCCATTCTCT TCAAATGTCC TAGGGTTGCT TCATACAGCA GACCATCGTA CCCAAAGCCA CTATGCATAT 023280 023281 GACTTGGTTA TCTCCTGCCA GGCTGTAGTC CAGTTAGTGC TCCCTTGGAA ATACTCAAGA CCTTAATGAA CTATCTATCT 023360 023361 GTGAATCTGT GAAGCTACCC ATTTCTTAGA GGCCTCTTTG GAGAGCTGGC TGTTGAATAC CCAGTATGAT GGTCCTTAGC 023440 023441 CTTCTTAGAC CTTTCCTGTA CCACTACCTC TATGCCTTTT GCCAAGTCCA AGTGTTCACC AGAAATGGAA CTGATGCCAG 023520 023521 AAAGACTACA GCTAACAATC TGAGCAGAAC AGTGAGCATG TCCTATCTGG GAAAAGCCCA GCCCATTGGG CTAAATCTCT 023600 023601 AGCTGAACAC AGAGACTATG CTCCTTCCAA TTATACTGGA AGCCCAACCA TGAGAAAACA GCACTTCAAC TACACTGTTC 023680 023681 AGAGCCATCA CCTGTTCACA CGTGTGTCTG TATACATGTA AACACACATT TTGCAATAAA AATGCTTCTC AGATGTACTG 023760 023761 CACCATAATA AATCAGCATT GTATGTACAG CTCAAAAAGA AGTATGGCAT ACCTATGGAA GAAGTCAAAG GCAAAGTGTA 023840 023841 GAAAAATACA TACAGTATGC TACCATTTGT ATAAAAAGGA GCCGTATCTA CTAAGTACAT GCACACACAG ACACACGTAT 023920 023921 ATTTGTTTAT ATAAAATACG TCTGGAAAGA TGCAATAGGA AAGTGTTGAG TGGTAACCTT TAGGGAAGGA AACTTGGGAA 024000 024001 TTAGGGTTGG GTGGGGAGAG TGTTATTTTT CACCCCTTTT GTACTCTGAA TTGGTTTTAC CATGTGTGTA AAGACTGTTG 024080 024081 TATGATTTTT GTAGCACAAC CCTTGAATAC ATAAAGCACG ATTGGCTCCC CAGAAGGCAG GTGTTGGCCA GGCAGTGGAT 024160 024161 GCACGGTAGG GCAGTGTGCA GCCCTGCATG CACGTGGCTG GTATGCCCTG CGGGCAGCAG CTCCCCGCAC ACAGTGCTGT 024240 024241 GAGTCTCTGG TTCATGTCAC TCTGTGGAGC AGGGGCTGCT CCAGCACAAA GAGGTTTTTG ACAGGGAAAG GCAGAGCCAG 024320 024321 AGTCAGGGCA GGCCCTGGGC GGGCTCCTAG AGAGCCCAAC CACCCTCTAA TAAGGGGTGC TCTCCACCCT ATCTGAGGAG 024400 024401 CAATTGGGAT CTCCTAGGAA GTGAAACTGT TACGTATGTC TTATTACAGA ATTTCCAGTG GAGTGATTCT GGAAGAAATG 024480 024481 TGTATGGCAT GTTGTGACTG CTATGTCTCA TGAAATATTT ACGTTTTTAT GTAACTTTTT TCCATTTTCA GATCATCTTT 024560 024561 TATTTTAACG CAAAATGACA ATATATTTTT CAATTAATTT GCCCAATATC TGTGTTTAAA TGTTTTCTAA TGCACACACG 024640 024641 TGTTTTAAAC TCATTAAAAA AATATGACTT AGATCCCATC CCACTTTCAT GTTTTATATT GCCAAAACTC TGCTTTTGGG 024720 024721 AGAGGTGAGT TATCTTCACT TCTGAAACAG TACTGCTTGG GAGCTGGTTT GGCCCTGGCT ATTCTGGGGA AATGACACAA 024800 024801 TATTGACCTA GAGGGGCCCT AATCTTTCCC CGCTAGAGCA CTACCTCTAA TAGGGTGAAG GATGGGAGAA AGAGGCTAGT 024880 024881 GAACCCACCT TCAGGTCTGT CCACTCAGGA CATGCCCACA CTAGCCTCTC CAGGGGCTCT GCCCTTGGCA TCCCCGTCCC 024960 024961 CCACCTGGGC TCTGGCAGAG AAGTCAGGCG GGAAGAAGCC GGCTGAGTGC CCGCCACTGT AAGAGGAAAC GAAGAGAAAC 025040 025041 AGCTCCAGTC AGCCCCAGAA GCGAGGCCTG GAAAAACTCT GCAGCTGGAG CTAACACAAA GGACTTTTCA GACCCTGCAG 025120 025121 CCAAGGTGCC CAGTGAGCTT TTTTTTTTTT TTTTTTTTTT TTTTTTAAAA AACAGCTATT AGGGTGACAA GCCTTTCCAA 025200 025201 AGGCCAGCAG TTGGCGAGAG TTTCCAGGAA GCTGGTCTGG CACTGGGCTG GGATTGGAGC AACTTTAACG AGTTAAGTTC 025280 025281 AGAAGGAAGG AGTCATCAGG AAAGGTTTAA GGTTCAACAA ACTTTTCAAA TTATTTTGCA AAAAGTTCTG GCTTTCCAAT 025360 025361 TCAAAGGCAT GTTTCGCTGT GACTGTTTTA AGCCAGAGCC TATTTAAAAG GCAACACAAC TAGCATGCTT CAGATTCACT 025440 025441 CACTCGAGGT ATTTGTCTAA ATCCTCCGAA TGGGCTTTGC AAGTGCCATC TAGTGCCTAG TAACACTGGG GCCATCTTAC 025520 025521 ACATCTCGAC AGGCAGCCCT CCTCCCCACG TGCCTCCCCC CAGCCTCTGT GGTCGTGTGC GCGCGGGCGC GCACACACAC 025600 025601 ACGCACGCAT GCACCTTCCC TAAGCAGGAA GCTGCTCTTT GCCAAGAGCG AATGGAATTC AGATTTCCAG AGGGTGTCCT 025680 025681 TGGCCTCCAG CTCTACGGCT GCATGATGAA GAAAGGTCCT AGTGTGTGTG CCGGGGGCTG GGAGAGAGGG GCCTCCAGCT 025760 025761 CTGCTCACAT CTATCTGGGC CCCAAGAAAA ACCCACAACT GGCTGTGCTC TCCCCAGCCA CACCCAGCCT TGGTCACATT 025840 025841 CCTTCCCTTC CTGAGCCCAC ACTGGGTGGC CCCGGCAAAC CAGCTTCCAC ACCTCCCTCC CCACCGGCAG GGAGACCTAG 025920 025921 CCCAAGCCCC CATGGGGCAG CCAGCAAGTA CAAATGAGGG GCTGCACCCC AGGCCCAAAG AGCCAGAAAG CACGGAGGGC 026000 026001 CCTCCCCCCA CCCCACCCCC AATGCTGGGC ATCCCCTTGT GGCTGCTGTC ACTCATGGGG AAAGAGACAC ACTCCCTTGT 026080 026081 CTAGCACCCG GTGAGCTGAG CTCCCATCCC TTCCTGTGCC TGCTTTCAGG AAGTCCCTCT TCATATCCAA CCTTGACTCT 026160 026161 CCTGGCTGTG GTGCTTGTGG GCCTGGGATT GAAGGGCCAT CACTGCCCTT TGCACCAGAG CTTCCCAACA TACCAGCAAG 026240 026241 AAGGGACTGT ACCCCTTCCC CTGTCCAGTC TGGGCCTTCC AAGCCCTGAG ATTCAGCAAC CTCAGGAATT AAACATTTAT 026320 026321 AGGAAAACAC CTATGCAGAC AAGGGACATG AGTCAGGGTG GTCATCAGCA GTAGCAAGGT GGGTAGGCTG GTCACGTTTA 026400 026401 GCTTCTCTTT AGCCCAAGTA ATAGGGTCTT CCACCTGCAT GGCCAGGGAG GGGATAGGCT GAGAGCAATC TTTCTACAGG 026480 026481 CTGTCAGCAT CAACAAGTGG TTGTGATGAG CAGGAGTCTG TATGGCTTTT CAGGTGTTCC GGCTCAAGGA GGCCCAACAC 026560 026561 CAAGTTGGAA CCTCCAGGCC TGGTGCCTAG GCAGAAGGTG GGCTAAACAA AGGCCAAGGG GAGCTCTGCT CTGTCACTTC 026640 026641 CCTTTGTTTG CTAATGAGAC TGTTTCCAAA AGCTGGCCTG GTAGCCTGTG GGATTGTTTC TCTCAAGATT TCTTCTAGGG 026720 026721 GAGAAGGTGG CTGAGGCTTT GCAGTCTGCA TCACCCAGTC CCCAGAATCT ACAGGGGACT CAGCTTGCCT AGTCACAGTT 026800 026801 CGGCTTTTGG CCTTGGCTCC AGGGCCCATT CTGATCCTCG TGCTTGGGTC AGGGATGGTC AGCACCCCTG CCCTGATGCT 026880 026881 GCCTGCTGGG GTCTCCTGCT GAGTACCGTG AAGGCCTACT GTGGCCTGAG AAGCCAACTT CACTGTCCCT TTTGGCCAGC 026960 026961 CCTAGACCCT ATATTTGTTC AAGTAACACA TTGATTCACT GGCTTCTCCT TTAGGCAAGG CCTGCAGGGG ACTCAGCTGG 027040 027041 GGTTCATGAT TCCTTGCCAC CTGTGGTGGG CCTGCATGGC CAGCCCAAGG CCTCAAGTGC CACATACTGC TCCCCTGACA 027120 027121 GTCAGGTGGC TAGGGTATGA CACTCAAGAA AATGCCCAGG CAGAACCCAG AGTTGGGGTC ACTTGGTCCA GCCCTTCTGA 027200 027201 AGGGGACTGG TTGGATCTGT TGCGGGGAGG AGACAGGCCA TGCTGGACCA GCAAAAAAGC ATAGAACTTG GAGTCTGGAA 027280 027281 CCTGACATCT GGCCTTGGCT CTGCCATCAG CTGGCTGTGT CCACTGGGCA AGGTCCTATC ATATCTGGTC TCAGTGCTTC 027360 027361 CATTTACCCA GAGTCCTTCC ATCACCTGAC ACCTACAGGG ATGCTTTCCC AATCAAAATT CAGGCCATGT GGTTTGATAA 027440 027441 GGCCACCTTC CAATGTGGAA GACAGGCTGG TAATGGAGAG GCCTGGGAGC ACAGAGCTCC TAGGCACTGC CATGGAATGT 027520 027521 GGGGACCTTA GGGAAGGATA TCTCAATTGA AGCTCTTCAG AGCCCCTGGG GTGGACTGTT CTGTACTCTC ATCCCCTAAC 027600 027601 CCATACCAGC CTGAGCTCAA TCATATCAGC CTGTGAAGGC TGCCCCACCA CACTGCTTCT GCACCCACCA CACCAGGCCC 027680 027681 CCTTGAGCTC CCACCTGGAG CCCACACACC CAGCTGGTGG GGTTCGTGGG GCAGTTCAAA AAGAAAAGCA GAAAAAAGCA 027760 027761 TTTGAGTATT TTGGACTGGA AGGAATTCAA TTTAACTTAA CAAATCAGGA CATGAACCTA AAGAAAACAC TGAAAAACAA 027840 027841 GCCCAACTTT GAAAGGCCCA AAGAGGGAGG ATTAGGTGGG AGAAGAAAGG TCCCCTGTGG GCAGAAGACA GCTGCTCAGT 027920 027921 CCAGACCAGG GACCAGGGGA GGATACTGGG CTTGAGTGCA GACCGGGCCA GGGTAGGGAG ACAAGCCCAA CATACACTCG 028000 028001 AGGACTTGAA GTCAGGGGTG CTAGCTGACT TTTTAGCCCA CTCTTTCTAC CCCAGATACA GAGACTAGCT GCCTGAGGAA 028080 028081 GCATAGCGGG GCCCACAGGC TGGCTGCCTG GTGCTGCCCA CCTCCTCTCC AGGGCTTGGC TCCCTGGGGC AGAAGGCTCA 028160 028161 GACCTATAAC CACAGTGGGG TTGCAGGGAT TTATTTGGGG GAAGAACCCT GACTGGGTCA GAATGATTAT GTGCATGCAT 028240 028241 GTATGTGTAT GTAGCTCCTT GTTCTCTGAA AAGCCTTGCC TACCACCCTA CTTCCCAAGT ACCCTCTATT GCCTTGCAAA 028320 028321 GTCACCCCTG CTCTCTGCCT CAGTTTCCCC AGCAGGGCAC CACAGGACAC TGCTGTGGCA AGGTTTATAC TTAGGGTGCA 028400 028401 GTGCAGTCTG ATCTTGTATA AATGCTCAGT GCCAAAGACT TAGGAGATAA GTCAGGCAGA GTCAAAATTA ACCTTTGAAA 028480 028481 AATCCCTTGA ATTGGCCCTA AAAATAATCC CTTTCTCAGA TCTTTGTGTA TATCCCCTGC TGGGTTGCTC TTCTGCCTGC 028560 028561 TAAAGTGGGA GAATCTCTGG GTGCACATCC AGAGTACCCT GGGAGAGGCA TGCCAGGTGT TCCTGTACCT TTTTCAGGAT 028640 028641 ATTCCCAGTG TCATCTTCAG AGGGAGCCTC TGAGGCTGCA GCCACACATG GGAAAAGATT ACTTATGGAG AAGATCAGAG 028720 028721 GCTAAGGGGC TGGGGATGGT GGGGACATCG GATTTTGAGG TCAGACCTGG ACTCCTGTCT ACCTCTGTCT CTCTACCTTT 028800 028801 TATTTTTCTT TCCTTTTCTC CTAACAAGGC CCTATTTCTA AGATGGCACC TCAGGCCTCC CATGGGACCA ACCAGGCCTG 028880 028881 ACAGACTAAC TGCTCAGACT AACTGCCAGA CTTCCTCCTG CTAGCCAGTC ACTACCAAGG ATGTGTGCCT CAGATACAGC 028960 028961 CCCTGCCCAG GACACCTACG TTGTCCCTAA CAGGGCCCAC ATATCTAAAG CATGAATGCC TAGCCAGGGG CTCTGGGGCA 029040 029041 CCATAAGAAG GCATGAAGCT GGGCCTGCCA ATTTGCATCC TGGGAGGGCA GGTCAGCCTT GTCCAGGCAA TCCAGGAGGC 029120 029121 TTCCCAGTGG CCCACTGGCC AGTGAGGACC TTTGACCTCC TTGGCTGGTG GCACCAGGTT TATGATGCAC ATAGAGGCTG 029200 029201 AACTTGAAGA ATTCTTATTG CAGAGGGCAG CCACAAGAGC CACTGGCCAG TGCCCAGATA ATATCTGCAG ACTGTTCCCT 029280 029281 CCTGCTCCAT GGGCCACAGA ATCCCTTTGT CTTGTTACTG CTACACTGCC TTCCTACCAA TCTTCAGGGT TCATCCTGGC 029360 029361 CTCTGCCATG CATATCCAGG CTCCCCCAGA GATTGTGTGT CTGGGAATGA GCCCTGGCTT CTGCTCCTAT CTCCCAGTGA 029440 029441 TACTGGCAAG TCCCTATCCT TCTTGAGGCT TCAATTTCCC CTTCTGTGAG CTGGGAGGAC AGGCCCACTA GATGCTCTCT 029520 029521 GAGGGACCTA CCAAGGATGT GGGCTGTGTG TCTCAGCCAA CAGCAGTATC TCCTAACCCC AACACAAGAA ATACACATAG 029600 029601 TAGGTGTCTG GTTAATGCTC TTGGAATTTC AGCCTATACT AACCATCTGA AAGCCACTGA GTCTGAACTC TGCTACCATA 029680 029681 TTTGAGATTA TCTCTCCATT GGGCACCTAT GGGTTGCCTA GAGACAAGCT ACCATGGTCC TCTTCCCTCG CCCGTCATGT 029760 029761 GCAGGGTCAA AGGCAGGTGA GCTACACAGC TCGCCCTGCT CTTCACTCTG CTTTAATGTG GGTGCTTGCC TTGGCAGATG 029840 029841 GGCCCGACAG TGATAAGAAC AAATGACAGA TGCATACTGG GGCACCTGTG ACTGCCATGA GACACAGTCC ACTGATTCTG 029920 029921 CCTCCAACCC CCTCCCCAGA GCAGAATAGT GAGTGCTAGG TTTCCGCCTG TACCTCCACG GGACCCCAAC AGCTCCTGAA 030000 030001 CCCCATTCCG AGATTTGAGG TTGTGACTTG GGGACCTCTA GACTTCCCTT CCCTCCACCT GACTCCAGAC TGTCCTGGAG 030080 030081 CTTGGGACTC TCAGGCCTCT AGGCACATCT TATTAAGGAC AGCAGCTGAC AGCCATATGT TGTGACCCCA TTTGTATCCC 030160 030161 ATGGTAACTC ATGACCTGGC AGTCTCAAAA GCTCTCAGGC CAAATAAGGA ATGTCCCCAC AGGATCTCCC ATCACAAAGA 030240 030241 GACATTCTAT GCTGGCTAAT ATTTTCAGGC ATTTCCCCGA GTCAGGTATG TGGCTGGATG CCTAACACCA TCTCCTCAAG 030320 030321 GCCTTACACT AATACTGTGA GATATACTCC CAATGTATAC AAGAGGAAAC TGAGGCTGAT AGAGATTAGG TGACTGCCCC 030400 030401 AGTGTCCTGT GGGCAGGATG AAATGACCCA AGCTGGCCAG GGCTCCCTGA CAGACCTTGT CCCTGGATTC AGCGAACATA 030480 030481 CATCAAACCA TTAGCTGACA AGGAATGAAT CTGACAAGCT GTTCATGACC ACCACACTGA AAACTACAGG GCAAGGTAAA 030560 030561 AGATATGAAA GTCAACCTAA ATAAACAAGG GACACATGAT GCCATGTTTC AGGAGCCCCA AAACTATAAG GATACCCATT 030640 030641 CTCCCATGCC CATCTAGAGG CTGCTGCGCC TAGAGGAGGC TTTCCATGGC AACTGGCATA TGTATGGTGA GGAGAAACCC 030720 030721 TGCAAAGACA GCAAAGCCAG TGATGGGGAA GGAGAAGCAG CCAGAGCCAG CAGGACCAGC TGTCAAAACC TGTTAGCAAA 030800 030801 CTACAGTGAG AAGGAAGCAA GGTCCTGGCC ACAAAGAACA ACTTGAATCT GACCAGTGGC ACCCAATAGG GTCCAGAAAC 030880 030881 AGAGCCACAC GTAGCCAGTG AGCTGATTGT AAAGACACTG ATACGGCAGG GTAGTTGGGA GAGGACGGGC CTTCCCATGC 030960 030961 CGGGTGCTGA GCTAGACTGG ATATCCAAGT AGGGGAAGAG TGGACCTTGA CCTCGGCCTC ACATTGGACA CAAAAATCAA 031040 031041 TCCCAGATGG AGTGCAGATC TACATGGGAA AGGTGAGCTA ATAAAGCTTT AGAATAAACC AGAATATCTT TATGACCTTG 031120 031121 GAGTAGTCAA AGTTTCTTAA ATAGGACACA AACAGCCCTA TCCAGAGAGG AAATGTTTGA TTAACTGGAC CACATGAAAA 031200 031201 TTAAGACCTT CTGTTCATCA AAAGACACCA TCAAGAGAGG AAGAAGGCAG CCTGCAGAGG GGGAGGCGAT ATTTGCAATG 031280 031281 TGTGTGTCTG TGAGAGAGTG TGAGTGTGTG TATCTCTCTC TCTGACAAAT GACTCCAGAA TATCTAAAGA TATATAGGAC 031360 031361 CATAAATAAA CATAAAACAG GCAGAAGATG TAGGCAATTT ATACAGAATG ATGTATCTGA CTAAATGATA ACATGGAAAG 031440 031441 GGACTCAACT TCATTAGTCA ACAGGTTACT GCAAATTAAA ATCACCATTT GATGCTGCTA GACATTCACC ATCATGGCTG 031520 031521 AAAAGGAAAC GACGGAAAAT GCCAAGTGTT AGGATGTGGA GCAGCCAGAA TGCTGCCTGT GGGAATGAAA ATTGGAATGA 031600 031601 CTCCTTTGGT AGACTGCTGG GTAGTATTCA CTAAGAGTAA ACATATGCCC ACCCAGGACC CTGCAGCTCC ACACATAGGC 031680 031681 ATATATTCCC CAGAAACGCA ACCTGATGCT CACCAAAAGC ATGTACAGAA TATTCTTAAA CAGCAACCTA CACCAGAAAC 031760 031761 TGCCTGCTGG CCACAGGTGG TAGAATGGAT GAATGATGTA GGCCATGCAC ACAATGGAGC ACCAGTCAGC AAGGAGCATG 031840 031841 AGGGAGCACT CTCCCTTCAG CCCCATAGAG AGGCTGCCAG ACATCAAATT GAGTGAGGGA CATTGGACAC AAAGGTGTAT 031920 031921 GAGTTGCATC ATTCCCACCG CATAAAGTTC AAATGTGGGC AAAGCTGGTC CTTGCTGCTA GCAGTTAGGC CTGTGGTTAA 032000 032001 TCTCAAGGTC AGTGACAGGA AATGGGAGCC TGAGAGGCTT TCTGGGGGTT CTGTTGCTTC CTCCGGGTGC TGCACACATG 032080 032081 GGTCCCAGGG ACTGAAGATG CCTCAAGCTG CGCACTTGAG ACCTGTGTAC TAATCTGTGT GCATGCACAT TACCCTTTAA 032160 032161 CTAAAAGTTT AACACCACCA CCCTATACCA GGGTAGCCCA GGTGAGCCTA ATTAGGTGGA TAGCCCTGGC CTTCAGGGCC 032240 032241 GCTAGGCCCA GCCCCATCCC ACTCCCTCAC TTAAGGGGAC ACGGCTTCCA GACTTCCTGA CTAGGTCACC TCCGTGCTTC 032320 032321 AGCCTCCAGA GGCTCTGCAG TTCAATCTCC CCTTTCAGGT ATCAGCAGAG CACACAAGAG ATCTATATGG GATGTGCCCC 032400 032401 CCGCCCAACC CCGCCCCGAC CCCCTGCCCC AACTGCCAGA AGTGTCTCCA TGACAATATC AGTGCAGTTG TGAAGTCCTT 032480 032481 TGCCCTCCAG CCACCTCTGT GGCGTGAATG TTCTCTCTGT CACATCCTCC AACACCATCT GCTTGGCTGA GGACCTGAGC 032560 032561 AGCATCATGG CTGGGAGTTC ACAAGTGGAG AGGGCTGAGC CTGGCCAGAG TGCACTGGGG CAGGGTGATT TGGATGGCCT 032640 032641 TTCCCTTGCA GAGGAAATGA GAAGCCTCAC TGCTTTCTTC TGGGCCATCC ACCTAGACAG TGCGGCCCTC TCCCCATAGC 032720 032721 AGCAGCCCTA GGCCAGCCGC TTCTTCCTCA CGTGCTCAGA CGGAGGAAGT GAAGTTTGGA AAGGTTAGGG GGCCACGGGG 032800 032801 GGCCGCCACA GCTGGGCTGA TGGCAGGCTG GAAGCCAGAT TGAGGGCATC TGATTCCCAA TCCCATCTCT TTCCCACTGA 032880 032881 GCCATTACGC CTCGGTTTTA ATTTAATTAG AAGAACATTT AATCCCCCCG TGCATTTCAG AGACGGGTTT GAGCCTGGCT 032960 032961 GGGGCTATGT GGGGCTCTGA CGGGGATCCT ATGACTCATG CAGCCCTGTA CAGCCCTCCC GGGCGGGCCC CCAGAGGGCT 033040 033041 TCCTTGGCAT CTCGTGCAGA CAGAGGTGGT CTGGAGCTTT GCAGAAGACA GGACACTGGT CTAGAAAGAC AAAATGGTCT 033120 033121 CATCTGTTCT TGACAAGCCC CTCACTCATC CTTCTGGACA CTGGTTCCCA GAATGTCCTT TCTGTCCTTT CCCACCAAAG 033200 033201 TTTACAGGGA GAGAAATATG GTGAGGAGCT TAGACACTCA CAGAGCTGCA GTGCCTGGTA CCCTGGGGTC TGTGGGAGTA 033280 033281 GGTCACAGTG GACCTGGATG TCTCCAAAAT GTCCCAGGCC AAGCTGGTCC CATCAAAAGA GCTAGCCCCT TGGTCCATGA 033360 033361 AGCCAAATTT GGGGCCACCC TTGTGACGTT TGCCCTTATT TCCAGACAGC ACAGACTGGC CCTGTCCTTG CTGACAAATG 033440 033441 CAGAATTCAG GAGACATTAG TAGTGATGTG GATGAAAGCC AGGCCACAGC GGCCTTGCTG GAAAAGAGCA ACTCGAATGT 033520 033521 CTTGGCGTGA GATTCTGCAG GGTCCAGGAG AAAGTTGAAG ACATGGAAAT TCTAATTAAC GCACACGGGG CTGTTTTTGC 033600 033601 TCAAGGATTT GCGAAGCTGT CATGTCACAA GAGGCCAGGC AAGCACATGC TTGCCAGGGA GGTGCTCACA GTCACCTGGT 033680 033681 GGGGGTCTCT GCAGCTTTCC CTCTGCCTTC TTTCCACCCC CTCTGCCCAG CCTCGGGGGT CCTGGTCCTC CCCCATGCCC 033760 033761 ATCTCAATGG GCCGGGTGCT CCCTGAGTGT CCCTCTGGAG AGTGGGACTG AGGGCGGTAT CTGTTAACCT CGAGCTGGGG 033840 033841 CTTGCCCATC TAAGATGCCA AAACAGAAGA GACAGGGGCC CTTCAGAGAA ACCACATGAC TGGGCTGGGC AGAGCCATAG 033920 033921 GCTGCAGGGC TTATGGGCCT GTCCTCTTGG GCCGTCTATC TCAGGTATCC ATGTGCAACC AATGGGGCAG ACGTGTGAAT 034000 034001 TCCAGGCCAG TCCTGGCTGG CTTGGCAGTT GGGGATGCAG TGTGAGGGAG GATTTCACAA AAATGATTTC AGCCTCCCAG 034080 034081 GGTTGCTTGG AGAAGCTCAC CCAGGCCACA CCTGCACACA GCCCCCAAGT TCAGAGCCGC AGATCCTCAG GCCCCTAGCC 034160 034161 CTGTGCCTCA GCACTGGCAC AATGTGTCTG CAGTCCTTGC TTCATCTTAG GCAGGGTTGA GTGAGCAGCA ATCCTAGGGC 034240 034241 TTCTCCATGC CTGGGGCTTT GGGGGTTCTG GGGAGGAAGA GACCAAGAGG GCTATACATG CCCTTCTCCC TCCTGGCACC 034320 034321 ATTCGAAAGG CTTAGGGAAC TGGTACTGAG GGCTTTGAGA GCCAAAGGAG GACACAGCCG TACAGCCTAA GTGTGTCCTG 034400 034401 GGGGGTTTAC TGAGCAGACG TTGGAAAGAT GAATGGAAAT CTGGTGGCTG CAGATGGGTG ACAAGGGCAT TCTAGATGGC 034480 034481 AGGTTACCAC ACGCAAGGCA CAGGGATGCA CACAGGCATG GCACCGTCCC CACCCACTGT CGTGCCAGTG ACCCTTGGTG 034560 034561 AGCAGAGGAT AGTGAGTGGG TCAGAATCCC AGGAACTCAT CCTGGCTCTT GGGGTACAGG GCTCCTCTTG TCATGGGGGT 034640 034641 GCTCCCCAAC TGCCCATGCA GGCCTACAGT CTCTACTTCC CACCTTTCTC TCAGAAGCCC TGTCATATGG TTCTGGGTGG 034720 034721 GAGACACAGG CTCAGGGAGT TTGAGGCTGG CAGGGACTCT CTTGTGCCCC ATTCAACCTA GGAAGACAGC TTCTGCCTGA 034800 034801 AAGGTGTGTT CGAGGCTGAG TCCTGGCCGC CCAGAGCTGG TTGAGGGTCC TGAGGCTGAG CAGTAGGGCC CACCTATAGG 034880 034881 CTGGGGTGCA GCGACGCCAC TCTTTATCTC CTGGGTACCC CGTGCCTCAG CTTGTCATGA CTCCCTAGCT TGCATCAGGC 034960 034961 CTGCTCACCC CCCACCCCAC CTCTGGCTAA CAGGCCCCGG AAAGAGGAGC TTCGCCCAGC CCCAGGGACC TTCCCGTAAT 035040 035041 CAAGGCTATA GTGACCTCAC CTCTCTGGGG CCCTGCGGGC GGGGAGAGCT CGAGATGGAA ACAAAATGTG TCTTTATTTA 035120 035121 TGTTTTTAAT TTGAATTCTG GAACTGGCCC AGCATGGTAA TACATTTAAC ATCAGTAGAA TGCTGAAGAA AAATGGAAAT 035200 035201 GTTTTTTGGT AACTGCCTCC CACCCACTCT GCCCCCTGTG AGACCCCAGC ACACATCCCT GTCCCTCACA CACACCAGGG 035280 035281 CGTGTGCCTC TCTTCCCAGT TCAGGGTCCA TGGGGCCAGG CTGCCCACAG GAGCTTCGCT GCATCCCTGA GCAGCTGGAG 035360 035361 CCGAATTTAA TTATGGGCAT CACTGGGCGG GCTGTGCAGG AGGTGGAGGA ATGCAGCCCC AATGCGGGCA GAAGACCTGC 035440 035441 ACGGCCCCCA CACCCCTGCC GCCAGGCGGT TTGGGCCCTG AGGAAACAGG GTGCCCACTG CTGCCAGCCT TCTCCCCCAG 035520 035521 ATGGAGTGGG GCCTCTACCC AGCCTGTATC CCAGAGGAGC CTGGGTTCCT AGGCCCTGAC ACTGTACGTG CCCACTCTCC 035600 035601 CCTTCAGGCC TCTCTGGAGG GACCGTACCC TGACTTCTGA GGATGCAGGA ACCCAGCTCC CCTGAAGCCT CAGCCCTGAG 035680 035681 TCTTCCCTGA CCAGAACACA ATGCCTCAAG GTGGCCCCTT TGCAGCAACC TCCTTGTTTT TCCCTCTCCC AGTCCCCTCT 035760 035761 TCAGATCCCT CACCCCAAGC CCCATGCCTG GGCTCCTTCC TGCCTTCCCA GGCTGGCTCA TATCTAGCAG CCACTTTTGG 035840 035841 AACAGCCTGC TCTGAGAGAG GCCTTGGTAA GTTACAGGGC AGGGACCTGG TTGGGTAATG ACTGGAGTCT CTGACCTGCC 035920 035921 TGGGCCCACT TATCACTGGA GGCCATGGGA GTGCCAACCT GAAAAGGCTG CAGGATCTTG CAGAATGGTA ATGTGCCAGA 036000 036001 CCCAAAGTGG GCAGAGAGCT TGGGGATGGA TGTTCAGGTC TCTCAGGCCC TGTCATCCTG GAGTGGAACA AGAAACAGCC 036080 036081 CAGTGTCCTA GATGACACAG CCACACTGGC TTGGGGTCAC CCTTGGGCAG GTGGGTAACC TCTGGCTCCA GGGAGCTTGG 036160 036161 CATGTGCTGA TACCAGCACT GGCAGCCCTC ACCCCCATAG TGGTGATTTA CTGGGCAGCT GCAAGTTTGG CTGTGATCCA 036240 036241 CATAAGTGCC TGGTCTCTCA CCACCTTCAC CTGCAGGGGC CTTGCAAGAC CCAAGAGTTG GTAAGGCCTG GCTGCCCAGC 036320 036321 TAGATGGACT GTGGGTGATG GCCCTCTCCT CCCAGTAGGA CTTTTTGCAT GTCTGGATGC TGGTCCGTGA CCAAGAGAAC 036400 036401 CAAGGTGAGC GAGAGCTCCA ACAGGAGAAG CAAGCAGCCA GAAGGATGAG AAGGGACAGT CCCCTCTCTG AGGGGACAGC 036480 036481 CAAGAGGCAA TACAGGCACT GCCACCTGTA TTGCACACAA CATGAGCCAC TAAACTAACA CTGATCACTT TGGAGGTCCA 036560 036561 TCATATCCAG GACTTGGTAC AGGCCTTGGC CACAGTGTAA GCCATCATTC TGCCTTCTGG TGCTGACCTG TACCTGGGCA 036640 036641 GCCCATCTGG CTACCAGCCT GCTCACACCT CTGCTCCTGC CTTTTTACCC AGCCAGGAGG GGCCCAGAAG CTCAGAGCCC 036720 036721 TATTCTCAGG GTGTCCATGA CTAGTCACCC CTGCTTTCCA GTGATCTGCT GGCTCCCTTG GAGCCTCTTC ACACCCTACC 036800 036801 CACCATGAGG TACTGCCAAC CTCTCTGTGA ACTGGGGGGG CCTGGAAAGA CAGTGGGCAG GTCCTGTCTG ATCATAATTA 036880 036881 CCCCTTAAGA TAGCCACTCC TTCCCTGGAG GTGGCCTCAT TCTGGCTACC CAACCCTGCC AGTTCTCTGG TTACACCTGC 036960 036961 AGCCCCCAGC ACCATGGGTC CCGATTTCCT CAGTGATTTG CAAGGCCAGG CCTTGCACCT GGCTGGCTGC AAAGGCAGGA 037040 037041 GGCCCAGGGC CTCACTACGA CAAAGACACA CATGGCTCAG GACAACCTCC TGACCCCCAG AGAGTCCAAA GAACAAAACA 037120 037121 CCCTTTAGAA AAATGTTGGT AGAGAGAAGG AGAGTTTCCA CAAGTGACCC TCAGAAGGGC CGCGAGTGTC ACTCACAGAT 037200 037201 CTTGACACAA AGACATTTAT CAAGGGGAAT CCCCAACGGG TTAGCAGCCA GAATGGGACT GTGGCCAGAA TGGACTTGGG 037280 037281 TGCCCCACTG ACCCCGCTGC ACGGCTGTCA CCGCTGGGCA CCCCAGCGGG GAGTCACATG TCGCAGGGGA ATCACACCGT 037360 037361 GGCCGGGCAC CGGGGATTGG CCTGGCCATG CCGTGACGGC GGGGGAGGAC GGGCATGCAT CCCAGGCCAG CTGTGCCTCA 037440 037441 GGGGAAGGCC AACTGGAAGG CGTGGAAAAT CAGCCATTTC CTCCACCTGA AGGAGCCCCT GAGGACAGCA GCAGCAACTG 037520 037521 GCAGACTGCA CCCGGCATCT GCCCCATGGC TTTGGCCAGG GTTCCATGGG GAAATGCTAA AAAACAAAGT CGTCTCTTTT 037600 037601 TTGGGGGGCA GGGGAGGGGG CTGGGGGAGA GAAAAACAAT CTCAGACTCT CAAAGCATGA AAACAAGTGG AAAATGATCA 037680 037681 GTCTGGTTTT CCATAAGTCA AAACAAGAGG ATCATGTTCC CAGGCTCAGT GGGAAGTGCC CTTGCTCTCC TCTCTTGCCT 037760 037761 GGTGCCTCCG TGTTGGGGCC AGGCAGACGG CAAGTGGTGG GCACTAGGCG AGTAGATAGC ACTCTGGCCA GAGAGCAAGG 037840 037841 CTTCCCCAGC ACCAAGTCTG ACTCCTTGAG CTCCAGTCCC CTCCAGCCCA GCCCTTCACG CACATGTAGG CACTCACTGT 037920 037921 GAGATGTGGG TGATGGGTGT CAGCAGAGTC TCCCCTTCCA GGTCCAGGTC CTCGGCGAAG CTGTTGGTTC TCATGAAATG 038000 038001 GGGCATGCTC ACTTCCAGCA GTGTTGGGCT CTTCCTTACT GAGGAGAAAG TGTGGGGACA GCACGTTAGG CCTCCCACCC 038080 038081 AACCTGCCAG TGCTGTGGAG CCAGGCCTGT GAGCTCCCAG GGCCAGGTGA GGAGTGGAGC TTGTGCCTGG AAGCTCCAGC 038160 038161 CCTGACAATC AGTTTTATAG TTGGGTGTTG GGGTGGGTGG GTGTTTAAGA TGGCCCCAAA GTGCCTGACA CCTCAGTGTC 038240 038241 TGAGGAGAAT AAAGGCCAGT GAATCATCTT CGGAGTGGTA ACTGTGCCTG GGGCTGTGCT CAGGTGTCCA AGACTCTCCC 038320 038321 CACCTCAGGT TCTGGGCCTC TTCCCATGTT CACAACTGAC ACTTGGGTCA AGAATAAAAC AGAGGTGACA GGCACAGGCC 038400 038401 TGGTAAGGGA CAACAGCTCC CACCACCATA CATTGTCACA CTCATACATT GACAGAGTAG TGGGTCAGGA AAGATGGGGT 038480 038481 GATAGGACCT CTGACCCATG AGGAATGGCA AGCCTGGGAG GTGGGGGCAG CCACAGAACT CCTTCCTCAA AACACGATGC 038560 038561 TACATCAACC AGTTGTACCC CCAATGAGGC ACAGGAGTCC CTCCAACAGC TGGCTTCACA TTATGATTCC TGGGCCCACC 038640 038641 TCTGCAACTT TGACACAGGA GCTCAGGATA CTGATCCTTA TCACTCCCCA CTCTCTGTTG ACACTATCAG TATTTGCTCT 038720 038721 TGGCTTATAT TTGTCTTCAT TTAAATATTT TATTGCAAAA GGATTAAGTA CTCATCTGTG AGAAGTGGAA TAATTCAAAG 038800 038801 ATTCACAATG GCTTTCCTCC CCCAAGGTCA TCAGTGTTAA CTGCCAACTA GATCCCTAGC CCACCCTCTC TGCTCATCCG 038880 038881 AGCAGCAGAT GCCAGGTGGG AGTTGCTTTT ATGCACATGG GATGTCACTG TGACTCTGTT CCTGTCACTC TGTAACATAA 038960 038961 GCTCATTTCA TTTTTCTCTA GGTATATAGG CATGGATTTA ATTATTTTAG TCATTACATA ATAGTCCACA GTTTAGATTG 039040 039041 GCCACAGCTA ACCATTCTGT ATATCATGGA CATTCAGGCT CTTATAGTTT TAAGCTGCTT AATTATTCAG ACTATGATGC 039120 039121 CATATTCATC TTTATTCTTA AAAGCTGACA TACTGGAGCA GGGTGAGAGG GTGTGTCCTT AGTAATTTTA ATAAATGTTG 039200 039201 CTAGATTGCT TTCCCAAGAA GTTGTAGCAA TTCAGGCTCC CCCAGCTTTC CCACATCCAT GCCTGAATGA AGTGTTGAAT 039280 039281 GAAGCCCGAA TGAAGGTTGT CAGCACCTTT TGCAGGGACT ATCAAGCATG GATGAAAACT GAGGCATTGC TGTTATTTCC 039360 039361 ATCTGTGTTG AATACCTTTT ATGGGCTTGG CATCTGTTTG GGTTTCCTCT TGCAGAATTG CCTGTTCATG TCCTTTGCTC 039440 039441 ACTTTTGCTT ATCACTTTGT AGGAATTTTC TATACATTAC AGACATTAAC TCCTTGTTAT ATGAGGCATA GATAGCTTCC 039520 039521 CCAGTCTGTT TTTTCACCTG AATTATGTTG CTTTTATCCT AGAAAATGTT TTATGTTTTT AAAGTGATAC ATCTTTTGCT 039600 039601 TTATAAAAAA GGAAGGTTTT CCCACATCAG CGTAATACAA TTCTCTCTTA AATTTATTCC TAATTTCACT ATTTGAATGT 039680 039681 GTTGTATGTA TACATATGTA TGTGTGTAAA AGTTTTAATG CATTTAGTAT CTATGCCTGA TAGGACAGAT GATCAACAAT 039760 039761 TAGAAAATGA AAATTTAAAG GGTACTACAT ACAAACTTAC TGAAAAAAAA TCTAAAATAA AACATAAAAC CATAAAATAT 039840 039841 CTTGAAGAAA ACATAAGAGA AAATCTCCAG GACCTTGGAT TTGGCAGTGA ATTCTGAAAT ACGAAACCAA AAGTTTAACT 039920 039921 CGTAAGAGAA AAAGAATCAA CAAATTGGAC TTTATCAAAA TTAAAAGCTT TTGCTGTGCA ACAGACACTG CTAATGGAAT 040000 040001 GAAAAGACAA AGCACAGACT TGGAAAGAAT ATTTGCATAT CACCTATCAG GTCAAGGACT TGCACTCAGA ATATATAAAG 040080 040081 AATGCTTACA ACTTGACAAT AAAGTGAACA ATCCAATTTT AAAAATGGAT TATAAATAAG CACATGAAAA GATACATAAT 040160 040161 TAACATAAAT ATGGAAATGC AAATTAGAAT CACAATGAAA TTCCATAAAT TAAAAAAAAA ATTCAAAACC TGACAATACC 040240 040241 AACCACTCTT GAGGATGTGG AACATGTAGA ACTCTCATAT GTTACTGGTG GGAATGCAAA ATGGCACAGT GACTTTAGGA 040320 040321 AATAGTTTAG CAATTTCTTA TTAAGTTAAA CATACACATA CCACATGACC TATCGGTTCC TTTCCCACCC AAGTGAATTG 040400 040401 AATTTTTATG TTCGCAAAAA CCTGTACATA AATGTGTATA GTAACTCTGC TCATAATTAC CAAATACTGG AAACAATGAA 040480 040481 GATGTCCTTC AACAGGTGAA TGCATAAACA AAATGTATAT ATTCATGCAA TGGAATACCA CCCAGCAATA AAAAGAAATT 040560 040561 AACTAATGAT TTATGCAACA ACATGGATGA ATCTCAAATG CATTTTGCTA AGCAGTGAAA GAAGCCAGAT GCAAAAGAAT 040640 040641 ACATATTATA GGATCCCATT TATAGGACAT TCTAGAAAAA CAAAACTACA GGGACATAAA ACAGATCAAT AGCTGCCAGT 040720 040721 GGTTAGGGGA GAAGTACTTG ACTTCAAAAG ACTCACCCCA GGGTATTTTT AGGGGTATGG AACTTCTGTG AATGATACTG 040800 040801 GATTGTGGAC ACATGACTCC AGACATCTGT CAAAACCCAC AGAACTGAAT CTCAAAGAGT GGATTTTACT GTATGCAAAT 040880 040881 TTAAAAAATT AACCCGGATG TTGGAGGACC CTACGATGAA AAGCAGACTA TGATGAGCGT GTTACAAACA AATGACATAG 040960 040961 CAGTGAAAGG AAAGGAGGAG GAGGAGCTGG CATATGTTGC TTTCAAAAAC ACTGTTTTGA CTGGACACTC TATGGTTAAA 041040 041041 GCAAAAGTCT GTCCTAAACA CTCTAATCTA GTAGGTAAAT TTGCTTCACA TAGGGTACTA CGTGTACAAT AGGGTTACAC 041120 041121 AAATAAGTAA ATGAACTGTA GGTAATGGGA GCCAGGTTTC TAGCTGTCAG AGAAAAAGCT ATAAATAAGT TGTGGGGGAG 041200 041201 GGGGCAAGGA TGAACTCTGG TCAGAAATGT CAGTATGAAC TCATGGTTAG CTTTATATAG ATACAGATAT GTAAAGATGT 041280 041281 ATGTGTACTC AGGTTACATA CATACATATA TTTCCTAGCT CTGTCCACTG AGAGGAGACT GAAGCAATGA TACCCTAGTA 041360 041361 GCCACGAGCA TACCCCGTGC CTAGATCCAG GTTTTCTATT CATTCTCCAG GGAGCCAGGG CTCTCTGGAT GAATGGATGA 041440 041441 TTCTAGGGCT AGGGTAGGGA AAATAAAAGA TGAGCCTGAA GTATTGTCAA GTGCTAGAAA AGAAATGCTT AAAAATAAAT 041520 041521 GAAAAGGATG GCGGGGGGCA CATCAAAAGG ACACATGAAC CCACCAGTGG CCACAGCTTG AACAATTTGA GCAACAAAAT 041600 041601 AAATAATATT GGACTATAAC TCAAAAAATA AATACTCCCA AATCCACACT GATAAAATTA AATAAACAAT TGGAGGAGAG 041680 041681 GGACAAATCT TCCTTATAAA GGAATTCCAA ATAAAAAATG TAGAAGGAAT GAGGAAAATA GAAGTACATC ACGGTAATAT 041760 041761 TTGCTGCAGG AAAACGATCC ATGAATGAAT GCTGAAATTA GTTAGTGAAA CTCAGAAACT TCACAGTTTC TTCCTTGAAA 041840 041841 TGTATTTTAA TTGCTGTGGT AGTTTTAACA TATTTGCAGA TTTTTTTTGA TACTCTCCTG CAGGAGGTAG AGTTGAACCC 041920 041921 CTCCCTTCCC CACCTTGAGT GTGGGCTATA CTTAGTGACT CGCTTCTAAA GACTAAGCTA TGGAAAGGGA AAAACAGCTA 042000 042001 TTCACTTACA GTGGAGGAGC CTGGCCGACA CCACTTTAAA CGAGTGGCTC AAGGTTAATA TTACCAGTGA TAAACCATGT 042080 042081 TGATGTCATG TTCCACAATG AGGAAAGCAT CTCACCTCAC TGGCCTCCTT CCCCTAAACC TATAACCCTG GTCTAGTCCT 042160 042161 GAGAAAACAC CAGACAAATC CAAACTGAGG GACAATGACA CCTGACTGGT ATTCTTCAAA AGTGTCAAGT TAATGAAGAA 042240 042241 CAAGACTGAG AAGCCCGTCA CCGATCAGAG ATGACAATAA ATGTAATGAT CGATCCTAGA TGGGATCTTG GAACAGAAAA 042320 042321 AGGACATTAG TAGTTAAACT GGGGAAATCC AAATAAATTT ATAACTCTAG CTTAATAGTG TACCAATGTT AATTTTTTAG 042400 042401 TTTTGGTCAA TGTACCATGG TTATATAAGA TGCTAACATT AGGGGAAGCT GGTGAAAGGG ATGTGGGTAC TCGGTACTAT 042480 042481 TTTTGTTTCT CTTCTGTAAA TAAAAAATGT GAGGTAACAA GAGAAAACAG AACCTGTATA CAATAGCACA AAAGAATATT 042560 042561 AATTATCTAA CTAAGTATAT GCAAGAACTC TGGAGAAAAT TGTAAAACTT TAGTAAGAGA CAATGAAGAA GATATAAATG 042640 042641 GAGAAATATG CCTTCATTCC AATGACTAGA AGACTCAATA CTGAAAAGAT TATCTCAAAA TCTGAATAAA TCTCTCCAAA 042720 042721 TCTTAATAAA AATCTCAAGG CTTCTGTGTG AGAACTTTGG CAAGCTGATT CTAACTGCGA CTTGGAAGTG CAAAAAGCCA 042800 042801 AGAATTGGCA ATATTCTTGA AGAAGAACAA GGTGGGAGAA CTTGCTGTAC CAAACATCAG TACTTCTTCC AAGGCAGTGG 042880 042881 TCATTAGGGC AATGTGGTAT TGACACAGGG AGAGACAAAT AGGCCAATGG GACAGGATTG AGCATTGGGA AACAGCCCAC 042960 042961 ACAAATATGG AAGCTTGCTG TGTATCAGAG GTGGCCTGCA CATCCTGGGA AGAGCATGGA CTTTTCAATC AAATGTTCAG 043040 043041 GAGCAGTTGG ATACCCACAC TGGAAAAACA TTAAGTTGGA CCCTTAATTA CCTCACATCA TATACCAAAA ATTCATTCTT 043120 043121 GTCATTCTAG GGGATTGAAG ACCTAACTAT GAAAAGCATA ACTATAAAGG TCACATGACT GAATATAGAA GAATATCTTA 043200 043201 ATGACATCAG CATTAGGATG GTTTTTTTTA AAAGAAGCAA TAACCATGAG AGAGAAGACT GAGTAATTTG ACATTAGAGT 043280 043281 TAAGACCCAA TCATCAAAAT ACACCTTAAA GAGTGAAAAG ACAGTGCCCA CAAAATGCAA AGGACTCCTA CAAATCAATA 043360 043361 GGAAAAATAT AAATGACTTA ATAGAAAATG GGCAATAGAC AAAGTAGCAC ATCACAAAAG AGGAATCCAA AAGGCTGATG 043440 043441 AGCATGTGGA AAGGTGTTGC GCCTGACTAG CAATCAGGGA AATGTAAATA AACTCAGGAG CTCATGGCCC GTGGGGGCGA 043520 043521 GTGGCAGACT TCCAGCAGGA AACCACACAG ACATTACTTA GTCACAGCCA GGAGAAGGGC TCAGAGTGAA AGGGCTCTGT 043600 043601 GCCCATGACA TCCTTAGAGA GACCAGGGAA GGACCTGTAA GGCTTGAAGA ATGTGCAGAT TTGGAGACCC ACAGGTCTGG 043680 043681 GACCTGGCAG AAGCATGTTA CTGCCCCCAT TTTAGAGATT TGGGGCTGAG ATTCAAGTAC CCTAGGTTAT ATAATGCAGT 043760 043761 TGTCAAGTGA CAGAGCTAAA ACTTCATCCA GGATTCAATT TTTTTTAAAG GAAGGAAGAA AGAAAAAACA TATTTTGATG 043840 043841 TTTGCATCAC TTGTATGTAG AAGGAACGAT GGAGCACAGG CTAGAACGTA GAGTTGCTTT CCAAACACCC ATGATGACAA 043920 043921 GTGCCCATCT CCAAAGCCTG AGGGCCAAGG GTGAGCCACC TGACCCCTGA GGAAGGTTCT GTCCTGGTGT TTTAGGAAAT 044000 044001 TAAAATGTGC ACATCAGTTG GCTGCCCAGA GTGGGTGGGA CCTGCACCTG CCAGAGAGGA ATGTGTGCTT TTTGGTTTAA 044080 044081 TCCTGGGAAC GGCATATGGG GCCCCTATAA CAAGGGGCAG AGAAGGCCTC CACAGATTTG TTTTTCCAAT TCAAGAGGAG 044160 044161 AGGTTATTGT CTGCTGGCTT GTGTGTTGGA GACTGTGGGG CGTGCTTTCT CCACCACAGG GAGGCAGTGA CCAGAGCTGC 044240 044241 CACCTCTTCC CTGTTTTCAC CTGTGGTCGT AGCCAGGTCA GGCATCTAGG AGAGCATGGA GGGGAGCTGG GGGTGGGTGG 044320 044321 GTGGGGATTC AGCTCTTTCC AGACACACTG GTGCTGCCTC TTTCAGGCCA GGGCTTGAGG GCAAGTGCTG TGCCCTAACA 044400 044401 GGTCTTGCTT GTCACCCCCA CCTCTGAAGT GGGTATTTCA CAGCCTGAAC TCACAGCTGC AGAGAAGGTT GAGCCCATGG 044480 044481 TGTACTTGAA AGGGCAGTTC ATCTGGATAT CCAGGCTCTG CAGGAGGTAC CGGAGCAATG CCAGGTGCCC TTTGCTGAAC 044560 044561 TGCCTAGAGT GGCTGGCCCT GGGGACAAAG AGCACAGCAT CCTGGTGACA ATGAAGTCAC ACTTTCCTAA GACAGTCCTG 044640 044641 GTTTTTGATG CTTTAATTCT TTGGCTGCCT TTGCTTTGTC AAGGCCAGGA TCTGGGCCTA AATTTTCAGG GCAGAACAAA 044720 044721 ACAATTTTGT TTTCTAGGAA AGTGGGAGGT CTGGGATGGC AAAGGCAGCC TCGGGCGTGG CGACTACCCC AGCTGGGGAC 044800 044801 GCTGGCTGCC AAGTCTCACC CTCTCAAGAG AACAGGAATC AAACTCAGCA CAGCATCCTC CTTTCTAGTC AGTGGTCCTG 044880 044881 CTCGATAGGG GGATTTGAAT TTTATTTTTT TAAAAATACA GGCACAGAAA AAAGACTAGA AGGAAACAGA TCCAAATGTT 044960 044961 AACTTTGTCT TTGGGTGATT TTCATTTCCT TCCTTATTGT GTCTGTGTTT TCTATTTTGC ATGATACTTT TCCAAGTCAA 045040 045041 GAAACAATAA TTTGTGGAAG TCTCCTGTAT CTGTGCCTTG CTCTCTGGCC CACGACCTTG CACATCTTAT CCTAGAGTTG 045120 045121 CCAGAATATG TCCCTCCACC TGGCCTGGAG CTGCCCATGA GGCTACATAG AGCTCTCCTA TCATGAAAGT CTTTGAGGCT 045200 045201 TTCTGTTCCC AAGAAATTCT GGTCTCACTT CCTCTGCCTT CTCATCGAGC CCCAGACCCC TCCCTGCCCA GATTAGGTCA 045280 045281 GCATTCAAGC CCCAAGTCCA GCCTATGACA AAGCTCAAAG CTCCAGCCCA TCTCTGCTGC CCTCTGCCCT CAAGAGACTC 045360 045361 TCGCCAGTGT CTGGGCCCTT CCTAGTAACT TCACCCAACC ACTCACCCCC TGCCCTTCCC CTCCTGATTG ATTAAAATCC 045440 045441 GGCCTAATCT CCCAGGTGTA ACCCAAGCCC TCTTCCACAA GCTTTCCAGG GCTCCGGAGA TTGCCCCCTC CCCTGTACGG 045520 045521 CTGCAGGGCT TATGTGTGCC TGGCGCTCAG CACGGGAACC TTGCCTTCTG CCTCACCCAT GTCTCCCCAG GGTTTGGCAC 045600 045601 AGGCGAGTTC CCTGAGCCAG CCTACTTCAC AAGGATGAAC AGAAGCTCTC CCTATCCTTT GCAAGTAGAA GCCCCCTCCC 045680 045681 TGGCCCCCTC AAGAAATCTC CCCCTCTCAG TGGATTCACC AAAGCCCTGC GGATCCTGCA CTGTGAAGGA GAAGCCCTCC 045760 045761 CCAGGGGCAT CCGGACAGCT GCAGCCAGGC CCTGCGTGAC ATTGCTGAGC CGCAGCCCCA CAGCCTGTGC CAGCTGCCCA 045840 045841 TGCCCGGCTC ATAGACCCTG AGCCAGAGTG GCCCCGCCAC CACCTGTGTC TCCACTCAGA GGCGAGAAGT AAGGGACATG 045920 045921 GATGGAAAGT GTAAAAGCCA TTCCCACAAC AGCTGCCAGG AACAAGGCGA GGAATGGAGT GAAAATGTAT ATTCACAGCT 046000 046001 GGCACCCAGT TCCGCTTAGG AAAATACCTT GCTTGAGTGG ACACCTGTTG TTTTTGCCTG CCAGCAGCCA GGCCTGGCTT 046080 046081 CTGGGAACAG CTTCTCAAAT CTTCCTTAGG GGGCTCTTCC TTTCCCACTC CTAGTGTGCA GTGTTTAGGT ACCCTCTGGC 046160 046161 CATCCCCAAA GGGGTCCCTG TGGACCTTGC CTCAGCCATC GGAGGTACAG CTGCAGGTCC AAGGATGGCT TGTACCCCAG 046240 046241 CTGAGGCCAA TAAGAACCTG GCCTTAGATT CTGGCAGGAA TCCTGGAAGA GATGACCTCG TTCTGCTGGG CTTCCTGAGC 046320 046321 TGTTGAATGC AAGCTGGTGG CCATTTTGCC CCTTTTAGAA AGTAGCTGCC TAAGGATACA GCCATCCCAT GGGGCCAATG 046400 046401 GATAGAGAGC AAGGGAAAGG GAGAACAAAA GAGGGAACGG GAAGGGAGAA GGGGAGTGCA AGAGGGGAGA GTGAGAGCAA 046480 046481 GTGAGCAAGA TCATCTCAGC TCTGGGGTCC AGCTGTGTCT GAAACAGCTG GGTCCAGCTG TGTGAGCCAA AAAATGTCCC 046560 046561 TTTTGTGCTT AAGCTTGTTT GAGTTGGGGT TCCATCATTT GTTACCAAGA GAGTCTTCAG GAATGTGCAT GACAAAGTTG 046640 046641 GGGGTGAGGT GTGAGCCTAC GGACATGGGC CTGGGGGCAG TCAAGGTTAC AAAATAGCTA AACTGGTCTG CACTGCCCCC 046720 046721 ACTAGTTTTC AGGGCAGAGG GCAGGGAGAA GGCTTGTGGG AAAGAAGCTG GCCTGAGGCC AAGGCCCTGG CCCTAGCCCT 046800 046801 GCAACAGCAC AGGGAACTCT TGGAAAGGGA TTTCCTAAGG TGGGACATTG GCTTTCTACT GCTGTGATGC AAGTCCTCAT 046880 046881 CTCCCCAAAC CTTCAGTGAG CCTCTCTCCA CACCCTGCTG TATGAGGATG TTTGATGCAA ATTATGGAAC ATGTTGGATC 046960 046961 TCACATTGGA TCAAAGGTGT GCAGAATAGA TTTGCCTCAA GCATGACAGT GATGTGACAC AGTCAAAGAT GACTTCCGGA 047040 047041 ATCCTGAGAA GTCCCAGGGA GGATGCTGGG CTTTCCAAAA CCTAAGTTTA GGATACTGAG GACCACACCC CACACCCCAA 047120 047121 ACACTTCTCC TTAGAATAAG TATAGCAAGC CTCAGCATAC ACAAATCTCA GAGTGAACGG AAATGTCTCT GCAGGCCCAA 047200 047201 GGGTGGGGTC TGAGTAGCGG GGGCGCTGAG GAAGACAGGC AGTGACAGAG CCAGGACAGG GTCAACCCTG AGCGTGAGTG 047280 047281 AGCCCAGGAA ACGGAAAGAG AGCAACACAG CCACCCACAC AACTAAAATC GACCCACCCG GGTCTCCATG CTGCAGGAAG 047360 047361 TCACTGTCTA GGTCTCCCAA GACACATTTT CAGGGGAAGG TTCCAGGCAG CAAGAGCAGC CCTAGGAAAC TTTAATATAC 047440 047441 AATGGAATCT GGGTTAAGCA CTATCTTCTC CAAGAGTTGA GCTCACAGGA CATTCCCCAG AAACCTCTGG AGAGGTGGGG 047520 047521 AGGAAAGTTT CTGGAGGTCT TTGGATGGAG AAAACAAAAA AGTGGCCTTG ATTTTCAAGA CAAAATTACA CAGGAAGAAA 047600 047601 AAAATGTTTT TAATCTAATT AAGAGCGATC TTTTCACCTT CATCACAACA TCGCGGAAAT GTGCCAGTTC TTAACTTCAC 047680 047681 ACAATAATCA AAGCAATTAG TGAGGGAGAA GCCTTGGAAA CCGGTGCAGA TGTTCTCAGA ATGTTTAATG GGGAAATGAG 047760 047761 TTGCAGGCCT CATTCTCAGC ATCCGGCTCC AGGCCCTGGC TACCAAATCC AGACATCTGC TGGGGCCCCA CCCCCAGGCC 047840 047841 CCGAGGGCGC GGGCTTGAGA AACACAGGTC CCTTCCCAGG CCACCTCCCA GCCAGGCCAG AACTGGGGCC GAGAGGCTCC 047920 047921 CCATAGCTTC TCAAATTGGA GCCTGGACAC AGTCAGAGCC ACCCCAGAAC TGGGGGGAGG CTCAACATCA AAATTATGTT 048000 048001 AACAACTGAT GTCAAAAGTA ATCAACTCAG CTTGGCTCCC CCACTGCTGC TGGCTGCAGG AGGGCTGTGA GTAGGAGGAG 048080 048081 AGCAAGCGGC CCCAGAGGGA CCCTCGGCTA TGACCCCCTC AGCCTGAACA CTACTTCAAG AAAAGATGTG GTGGCATCTG 048160 048161 TCTGGTATGG TCCTGTGGGC TCCATTCCAA TGCTAATGGA CTCTTAAGGG GCCCAGGAAT CAAAATGGTC AACACTTGAG 048240 048241 GAATTTCCAG TAATCAGAGA AAACGTATAG AAATGAGGAT GATGCTTACT TAGGAAATGG CCTATTACAG GAAACAGAGG 048320 048321 GCCACGTGGC TAATGTCAGT GAGCTGTGGG AGAGACAGAG ACCCCAGGTG GGGCAGGCAG ATCAGCAAAT CTTGGAGGAC 048400 048401 CTGCTATGTG GCAGGCACTG GAGACATGGA GGTAAAGAAC ACAATATCCA TGTTCTCAGG GACACACTCA TATGCCCTTA 048480 048481 GCATTCACGT TCTTCACACT GACAGCTTCT TAATGCAAGC CCACCAGATA CTTTCATAAG CACTACCTCT GACTTCAGGC 048560 048561 ACTTGCTGAG CTGCACACAG GGCAGGCCAA AAGGAATGGA AAGTGAGCCA CCACCGGGGC AGCACTCACT AGTGAAAGAT 048640 048641 AAATACCCCA GCTCTCTCAG CCGCTTGTAG AACTCTGAGG AGTGTTCTGT GCAGCTTCCC AGCTGCCCAC CATGAAGCTC 048720 048721 TTTCTCAATA AGTGACCAGC ACAGCTTAAT TCCTGAATTA AGCTGTGTGT GCTGTGAGAC TGACACAAGA CAGGGTGACA 048800 048801 GGAAGCTGTC GGAACATTTG AGTAGGGAAG CAGCAAGATC CACTGTACAT TTAAAGAACT CCCTTGAGCT GTTATGTGAA 048880 048881 GAATGGAGTA CAGGAAGCAA GAGTGGAAAT CAAGAGACCA GTAATGAGGT ATGGACAACA ATGTAGGCAG AGAAATGGTG 048960 048961 GTGGTTTTAA CCAGGGAGAT AGCTGGAGAG ACTAGGTGTG GGCAAATCCA GAGAGTTGAT AAGACATACT GATAGATTAG 049040 049041 AAAGGGGTAC TAAGAAAAAA GGATAATTTA AAAAAGACTT TCAGCCAGGC TTGGAGAAAA ATAGCATGCT GCTCCTCATC 049120 049121 CCCTCTGACT ATAAATCATC TCACTCATCC TCCCCTAAAA GCATAAAATC AGTAAGTGCA AATAAAACCA CATGACCCAT 049200 049201 GCTGTTAGCA GTATTAGGAG AAAGAATACC TTCAAATTGC CTGTGGGTAG CAAAGTGAGC CAAATTCCAA TAGCATTCTA 049280 049281 GTCCCCTGCC CAGCACTGCA AAACTGCATA CAGAATCAGA GAAGAGGCTT AAAATGCTTT GTCAAAAAGT TTGAAGGTAG 049360 049361 TTAGCAACAT CAGCAAAAAT AGAGGAGTAA GTACCTCTAA GGAGCCTTCT TGCCTTCACA GACATCCTAA GCACCAAGCA 049440 049441 GCCTAAGCCA CTGATGAACT TGCAGATACC ACTGATGTGG ATTATAGTCT AATTAATTGT AGAGACACCA CACTTCTGCA 049520 049521 CTGAACCAGA ACCAAAGCCA AAGCACCCTA CCCAAATGAT ACTACAGACG CGTGTACAGG AAAAGTCCTT ACTAAGGCTA 049600 049601 CTCCATAAAA TTGGAAGTCT CTGTTATTCC AGATATGCAG ATATCAACTT GGGGACACAA AAAACTTGGG GGGAAAAAAA 049680 049681 CAAGAAAACA TGACTTGCCA AAAGAACACA ATAATTCTCC AATAATAGAC TCCAAAGTAA AGGAAATCTT AAGGAAACCC 049760 049761 AATGAGATAC AAGAGAACAC AAATAGACAA TACAAACATA TCAGGAAAAC AATTCATTAT CTAAATGGGA AATCCAGCAG 049840 049841 AGTTAGATAT GAAAAAGAAC CAAACAAAAA TCCTGGAGGT GATAAATTAA ATGAATGAAA TAAAAAATAC AATTGAAAGC 049920 049921 TTCAAAAGCC GGCTAAGTCA AGCAGAAGAA ATAATTTCTA AATTTGAAGA CAGGTGTTTT GCAATAAACC AGACAGATTT 050000 050001 AAAAAATAAC AATAAAAAAG AATGAAGAAT GCCTGCGTGA CATATGAGAC ACTATTAAGC TAACAATATT TCACATTTTG 050080 050081 GGAGTTCCAG AAGAAGTGTT GGGATAAGGA CCAGAAAATC TATTTAAGAA GATAATACCT GAAAACTGCC AAAGTTTGGG 050160 050161 AGAGAAAGAG ACTAACAGAT AAAGGAAGCT CACAAATCCC TAAATAGATT CAACCCTAAA AGGGCCTCTC TGAGGCACAT 050240 050241 TTTCATCAAA CTGTCAAAAA TCAAAGAGAG AATTTAAAAA ACAAGAGAGA AGCATGAAGT CACATATAAG GGAATCAACA 050320 050321 GCAGATTAAC AGATTTTTCA GCAGAAACCT TCTAGGCCAG GAAAGAATTG AATGCCATAT TAAAAGTGCT GCAAGGTGGG 050400 050401 GAAAAGCTCA CAAAATTGCT AGCCACAAAT ACTATACCCA GCAAAGCTAT CCTTCAGAAA TGAAGCAGAA TGAGGGAAGA 050480 050481 AATTTTGCCT CCCTCAGACA AGCAAAAACT GAGGGAATTC ATTACTACTA AATCAGCCCC ACAAGAAATG CTTAAGGGAG 050560 050561 TACTACATCT GGAAGTAGGA GGATGATATC TACCATCATG AAACTACAAA AGCATAAAAC ACTAGTAGAG CAGATACACA 050640 050641 AATGAGAAAG GAAAAGGAAT AAAAGATTAT CACTACAGAA AACCAAAAAA TTGCAAAGAA AAACAATGAG AGGAAACAAA 050720 050721 AGTATACAAA TCAGTCAGAA AACAATAAAA TGACAGGAGT AAGTCCTCAC CTATTGATAA CAATCTTGAA TGTAGGTAAT 050800 050801 TTAAATTTCC CAAATGAAAG ATAGATACTG GCTAAATGAA TTAAAAAAAT AAAACCCAAT TACATGCTGC CTATAAGAAA 050880 050881 CTGACTTCAC CTGTAAAGAC ACCCATAGAC TGTAAGGGAA TGGATAGAAA AAGATATTCC ACACAAACAG ACACCAAAAG 050960 050961 CATGCAGGAG TAGACAGACA AAAAATACTG AGTCAAAAAA AAAAAAAAAA AAAAAAAGAA AAAGAAAAAA GAGACAAAGG 051040 051041 AGGTCATTAT ATAATTATAA ATGGATCAAT TCAGCAAGAA GATATAACAA TTATATATGC AACCAACAAC ACTGGAGTAC 051120 051121 CCAGGTATAT TAAACAAATA TTATTAGTGC TAAAGAGATA GACCCCAATA CAATAATAGT TAGGGATGGC AACATTTCAT 051200 051201 ACTCAGCATT GGACAATTCA TTTGGATGGA AAAATATCAA CAAGGAAATA TTAGATTTGA ACTGCTGCTT CGTTAGCACA 051280 051281 CAGCACATTC TCCAGGATAT ACCATATGTT AGGACACAAA ACGGGTCTCA ATAAATTTTT AAAAGTCAAA ATCTTATCAA 051360 051361 GTATCTTCTC AGACCACAAT GGAATAAAAC TGGAAATCAA TAACAAGAGG AACTTCTGAA ATTGAACAGA TACACGGAAA 051440 051441 TCAAACTACA TGTTCCTGAA TGACCACTGT GTCTATGAAG AAATTGATTT TAAAAATTTA AAAATTCTTT GAAACAAATG 051520 051521 AAAATAGAAA CACAGCATAC AAAAATGTAT AGGGTACAAC AAAAGAAGTG CTATGAGGGA CATTTATTTC AATAAACACC 051600 051601 CACATCAATA AGGTAGAAAG TTTTTAAACA AATAACCTAA TAAACGCATC TCAAGGAACT AGAAAAGCAA GAACAAATCA 051680 051681 AACCTAAAAT TAGAAGGAAA TAAATAGTAA AGATCAGAGC AGATCTAAAT GAAATAGAGA TAAAAGGTAA AAAAGACAAA 051760 051761 AGATCAATGA AATGAGGCCT CCCCCCCACC CCCCGAGACA CGGTCTCACT CTGTCACCCA GGCTAGAGCG CAGTGGTGTG 051840 051841 ATCTTGGCTC ACTGTAACCT CTGCTTCCTG GGCTCAAGCA ATCCTCCTGC CTCAGCTTCT GAGTAGATGT GCAGCACCAC 051920 051921 ACCTCGCTAA TTTTTTTTTT TTTTTTTGGT AGAGATGGGG GTTTGCCATG TTGCTCAGGC TGGTCTCAAA CTCCTGGACT 052000 052001 CAAGCGATCG GCCTGCCTTG GCCTTCCAAA GTACTGGGTT TACAGGTGTG AGCCAACAAA CCCAGCCAAA AAACTGATTT 052080 052081 TTTGAAAAGA GAAAATCAAT AAACCATTAG CTAGACTAAC CAAGAAGACC CAATAAATAA AATCAGAAAT GAAAAAGGAG 052160 052161 ACTTACAATG GACACCACAG AAATACAAAA GATTATTAGA GACCATTATG AACAACTATA TGTCAACAAT TAGAAAACCT 052240 052241 AGAGGAAAGA GATAAATTCC TGGACATATA TAACCTCCCA AGATTGAACC AGGAAGAAAA AAAATCTGAA CAGAGCAATA 052320 052321 ACAAGGAATG AGATTGTATC AGTAATAAAG TCTCCCAGTA AAGAAAACCT CAGGATTGCA CGGGTTTTCT ACTGAATTCT 052400 052401 ACCAAACCTT TAAAGAACTA ACATGAATTC TTCTCAGACA ATTCCAAAAG ACTGAAGAGA AAGGAATTCT CCCTAACTCA 052480 052481 TTCTGTGAGG CAAGCAGTAT CTTGATACCA AAACCAGATA AGGACACAAT AACAGCAAAA AAGAAAACTA CAGGCCAATC 052560 052561 TCCCTGATGA ACATAGATGC AGAATCCTCA GAAACAAAAC ACACACACAG ACACACAAAC TAGCAATCTG AATCCAATCG 052640 052641 CACATCAAAA AGATAATACA CCATAATCAA GTGGGATTTA TCCCAGGGAT TCAAGGATGG TTCAACATAT ACAAATCAAT 052720 052721 AAATGTGATA CATCACATTA ACAGAAGGAA GGACAAAAAA ATACATGATC ATCTCAATAG ATGCAGAAAA AGCATCTGAT 052800 052801 AAAATTCAAA ATCTCTTCAT GATAAAAAAA AAAGCTCATC ACATAATGTC TAGAAGGAAC ATAACTCAAT GAAGGTCATA 052880 052881 TATGACAAAC CCACAGCCAC CTGGGGAAAA GCTAAACACC TTCTCTCTTA GAACTAGAAC AAGACAAGGA TGCCCACTTT 052960 052961 CACTATTCTT ATTCAGCAGA GTAAGAAAAG TCCTCACCAG AACAATTAGG CAAGTAAAAG AAAAAGGGTA TCCAAATTGG 053040 053041 AAAAGAGAAT GTCATATTGT CCTTTGCAGA TGGCATAATC TTATACATAG AAAAACCTAA AGATTCCACC AAAATCTTTT 053120 053121 AGAACTGGTA AAGGAATTCA ATAAAGTTGC AGGATAAAAA AATCAACAAA CAAAAATTAG TAGGTGTGGA CATGATGGCT 053200 053201 CATGCTTGTA ATTTCAGCAC TTTGAAAGGA TGAGGCGGGT GGATTGCTTG AGCCCAGGAG TTTGAGACTG TCCTGGGCAA 053280 053281 CATGGCAAAA CCTCATCAGT ACAAAAATGA GCTGGGCGTG GTGGCCTGCA CCTGAAGTTC AGCTACTCAG GAGGCTGAGA 053360 053361 TGGGAGGATC ACTTGAACCT CGGAGGTGAA GGTTGCAGTG AGCAGAAATT GCACCATTGC ACCCCAGCCT GGGCAACAGA 053440 053441 GTGAGACCCT GTCTGCACTC CCCTGCCTCC CCCAAAAAAT CAGTAGCATT TCTGTGAAAC AGCAAATTAG CCAAAAGAGA 053520 053521 AATGAAGAAA GCAATCCCAT TTGCAATAGC TACAAAAAAA AGCAAAGCTT AACCAAGGAG GTGAAAGATT TCCACAATGA 053600 053601 AAACTATAAA ATACTGATAA CAGTAATTGA AGAGGCTACA AAATTTTTTG AGACATCCCA TGCTCATGGA TTGAAAGAAA 053680 053681 AATGTTAAAA TGATCATATT TACCTATAGC AATATACAGA TGCTATGAAA TCCCTATCCA GATATCAGCA GGGGCTTCAA 053760 053761 GATGGCTGAC TAGAGGCATC TGGCACTCAC CTCCTCCACA AAATATAGCA AGTAGGTAAC CACAGTTTAT ATAGATCGCC 053840 053841 TCTGAGAGAA TGCTGGAATT CAACTGAGAA GTAATAAGAA AAACCCAATG CAAGGGATAA GAGGGGAGTC AGGCAGTCTG 053920 053921 CTTCTATGGG ACTGGCTGGG ATCATGAAGA GACTCCTCGA TGTGCAGAAA GGTAAGTAAG TGAGCCCCTA GTGGTCCACA 054000 054001 TTCCCACAGC AGACTCCTGA AATCCTAGTC AGAGAACCCC CTGACCCATA GATGCCTTGA GACTAACAAG AGGCTACCTA 054080 054081 CAGACTGTGA AATGGCAATG AACAGCTCCC AGAGAGGGAG ATCACCCTGA ATCCTCAGGC AATTCACACA TCCCCTGAAT 054160 054161 CCTCAGGCAA CTTCAGGAAA GTCCCATTTT GATAGCCCAA CCCCCACCAG ACTGCATCTG CTGTGGGCCC CACATCCCTC 054240 054241 TATCTCATCC CTGGAGCCCC ATGGACATCC CTTACACAAA GCTGGTTGCC ACTCCTGACT GCTCCCTCCA GGCCAAAGCA 054320 054321 TGAGCCATTG GCAATACTCT GCTACCTCCG AAGCAAGGCT GCCATGAGGA AAGGTGACCC TGCCCATAGT CACCACCTGG 054400 054401 GGCCGAAGCA TGCATTGCCC AACTGCCTGT TTATAGCTGC TGCCACTGAA AGCAATCCCA CTCAACTTCC CCAGGAGTAG 054480 054481 GGCTGCAATA GAGTTGCTGC TGCCCCAACA TGAGCATTCA GCAGGGTATA CAGGGATCTT CCTGTGCCTG CCTACCACAG 054560 054561 TCAGTACATT CTTGCATTAC TGGAGGGCCT CAGGACAGGC CCACCTGGCC TGGTCCCACC CTCTTTTCTC CCAGTGCCAG 054640 054641 CGCATACCAT CTCTGGGCCT AGGGATCACC CTGCCCTATC CAGTATTGTT GGCACCTGAG CACTCCTGGG GGCTTGAGGA 054720 054721 CTGCCCTACC CAACTGACCA TTACCACCAC AACTGGCATT CACTTGAATT TGCCACCTGT GGGCCTTGGG ACAAGCTCAT 054800 054801 CCAGCTTATC CCAGCCATCC CAATACCAGC ATGGACACCT TGGGAGGCAG AAGATTGTTC TGCCACTGCT ACTGCCATTG 054880 054881 CCCAAGCCAT ATCTGCTGCT CAGAGCTCAA GGACCTACCC ACCCTGTGGC CCAGCTCTGT CATCATTGGC ACCTGAGCAA 054960 054961 GTTGCCTGGA GGCCCAAAAT TGGTTTCCCT GGACTTGCTA ACACTGGTAC CAGCATACAC TACCATTGGG CCCAAGGATA 055040 055041 AGCATTCGGG GCCAGCCACT GCTGCCACTG GGGCCTGAGG ACTGGCCCAG CTGGTGTCCC TATCCCCAGC CAGACTTTAC 055120 055121 CACAGCCTCC ACCAACAACT GCATCCTAAA CTACAGAGGA ACTCCCAGAC ACTACTGGTG CTGTTTACAG CTGAAAAAAA 055200 055201 TTCCATGGAG ATCACACTAC TGCAGGCACC CAGAATCAAA ACCAAAGTGC CCTGCCCAAA GAACACCATA GATATATCTT 055280 055281 CAGGAACAAG ACTCTCTTAG GAAAGACAGA TCAAAAAATT GGAAGAAACT ACTGTTACAC CAGATGTGCA GATACCAGTG 055360 055361 TAAGCACACA AGAAACATGA AAAGGCAAAA CATGACAACT CCTAAGGAAT GCAATAATTC TCCAACAGAT TCCAGTGAAA 055440 055441 AAGAAATTGA TGAAACCTTG AAAAATTCAA TATAATATTA AAGAAGATCT GATAGACTAT ACAAAGAAAT CAGAAAAAAC 055520 055521 AATTCGGGGT ATGAATGAGA AATTTGCCCA AGAGATAGAT ATAAAAAGAA CCAAACAGAT ATTCTGGAAT TGAATAATAG 055600 055601 ATTGAATGAA ATAAAAAACA TATTTGAAAG CTTCAATAAC AGACCACAAC AAGCAGAAGA AAGAATTTCA CACCTTGAAG 055680 055681 ATAAGTCTTT TGAAATGACT CAGACAAAAA TATAGAAAAA ATAGAAAAGA ATGAACAAAG GCTATGTGAC TATAGGATGC 055760 055761 CATAAGGTGA CACCTTCAGT GTCCCAGAAG GTGAAGAGCA AACCAAAAGA TTATAAAACC TATTTAATGA AATAATACCT 055840 055841 GAACACTTCC CAATCTCCCA AGAGATTTAG ATCCAAATAT AGGAATCTCA GAACCCTAAA TAGATACAAT TCAGAAAGGT 055920 055921 CTTTTCCACA GCACATTATA GCAAATTGCC CATCCCAAGA CAAAGAGAGA ATCATAAAAC CAGCGATAAA AGAGGTTGTA 056000 056001 GACACTTACA AGGGAACAAC CTGCAGACTA ACAGATTTTT CAGCAGAAAC TTTACAGGCC AGGAGGATGG GATTATATAC 056080 056081 GCAGAGTGCT GAAAGAAAAA ACAAAACCAA AAACCTGCCA GCCAGGAATA CTGTACTTAG CAAAGTTATA TTCGTCAGAA 056160 056161 ATGAAGGAGA AATAAAGTAT TTCCCTTAAA AGTAAAAGCT CAGGGAATTA ATTGCCACTA CACTGGCACT ACAAAAAATG 056240 056241 CTTAAGGGAG TCTTACAGGA AGAAGTGAAA GGACAACTTC ATGAAAGCAC ACAAAATAAT CAGAAATCAA TTAATGACAG 056320 056321 GAATAAGCCC TCACATATCA ACAATAACCT TGCATATAAA TAGATTAAAC TTTCTACTTA AAAGACAGAC TGGCTGAATG 056400 056401 GACTTAAAAA CATGACCCAT CTAAATGCTA TCTACAAGAA ACGCATCTCA CCTGTAAAGA CACATAGTTG AAAGAAAGGA 056480 056481 ATGGGAAAAG ATATTACATG CAAAAGGAAA CAAAAACCAA ACAGGAGTAG CTATACTTTC ATCAGATAAA ACAAAGGTTA 056560 056561 AGCTAAAAAC ACTAAAAAGA GACGAAGTCA TTATATAGTG ACAGAGGGAT CAATTGACCA AGAGGATATA ACAATTCTAA 056640 056641 ACATATATGC ACCCAACACC AAAGCACCCA GATATATAAG GCAAACATCA AATCTGAAGG GAAAGGTAGA CTTCAACACA 056720 056721 ATAATCTTGG GAACTTCAAT TCTCCATTTC CAGTATTAGA CAGATCATCT AGACAAAAAA TTAACAAAGA AACATTGGAT 056800 056801 TTAAACTGCA CTTTATACCA AATGGACCTA ACAGACATTT ACAGACCAGT TCATAAAACA GCTGCAGAAT ATACACTCTT 056880 056881 CTCATCAGTA CATGGAACAC TCTCCAGGAT ACATTATATG TTAGGACACT AAGTATGATT TTAAATATAT ATATATTTTA 056960 056961 AATTGGATTC ATATCACATA TCTTCTCAGA CCACAATAGC ATAAAACTAT AAATAAATAA GAGGAGCATT CAAAACTGTA 057040 057041 TAAATAAATG GAAATTAACA TGTTCCTGAA TGACCAATGG GTCAAAGAAG AAATTAAGGC AGAAATAAAA AATTTACTGA 057120 057121 AACAAGTGAA AATAGAAGCA CAACATTCTG AAACTTAAGG GATACTGCAA AAGCAATGCT AAGAGGAAAG TTTATTGTAA 057200 057201 TAAATGCCTC CATTAAAAAA GGTAGAAAAG ATCTTAAATA ATCTAATGAT ACACCTGAAG GAACCAGAAA AGCAAGAACA 057280 057281 AACCATACTA AACATAAAAT TAGTAGAAGG AAAGAAATAA CGAAGATCAG AGCAGAACTA AACAAGAAAC TAAATAAATA 057360 057361 TAAAGGATCA ATGAAATGCA AAATCGGTTT TTGAAAAGAA ACAAAATAAC CAGTGGCTAA ACTATCCAAG AAGAAAAGAG 057440 057441 AGAAGACCTA CATGAATAAA ATCAAAAATG AAAAAGGGGA TATTACAACT CATACCATGA AATACAAAAA TCAAAACTCT 057520 057521 TCAGTCTGAT CAATAAATTG ATTACAGTTA CAGGATTTAA AAATCAGGCT TATTTCTATA TACCAATAAA GAACCAGCTG 057600 057601 AGAAAGAAAT CAAGAAGGCA TTATCTTTTA CAACCACTAC AAAAAATCTA GGAATGAGTT TAACCAAAGA GGTGAGAAAC 057680 057681 CTCTAACAAG GAAAACTACA AAAGTCTGAT GAAAGAAATT GAAAAGAACA CACAAAAAAC ATCCCATTCT CATGGATTGG 057760 057761 GAGAATTAAC AAAATTAAAA TGACCATACT ACCCAAAGCA ATCTACAGAT TCAATGCAGT CTCTCTCAAA ATACCAATGC 057840 057841 CATTTTTCAT GGAAATAGAA AAAATCCTAA AATTCAGATG GAACCAAAAA AGAGCTGGAA TAGCCACAGC AATTCTGAGC 057920 057921 AAAAATAACA AAGTTGGATG CATCACACTG CCTGATTTAA AAATATAAGG CTATAGCATT AAAAGCAGCA TGGTATTGGA 058000 058001 ATAAAAACTG ATAGACCAAT GGAACAGAGT AGAACCTGGA AGTAAATCCA TGTATTTACA GCCAACTGAT TTTTGACAAA 058080 058081 GATGCCAAGA ACATACACTG GGAAAAGAGC ACCCTCTTCA CTTAATGGAG CTGGGAAAAT AAGATATCCA TGTGAAAAAT 058160 058161 GAAACCGTTT CTATCTCTTG CTATACTAAA ATCAACTCAA GATGGGTTAA AGACTTAAAC ATGAGGCATG AAACTATAAC 058240 058241 ATCACTATTA ATGAAGGAGA CATTGGGGAA ACACTTTAGG ACATTGGTCT AGGGAAAGAT TTTATGGATA AGACCTCAAA 058320 058321 AACACAGACA AAAACAAAAA TAGACAAATG GGACTATATT AAATGATAAA GCTTGTACAC AACAAGGGAA ACAATCACCA 058400 058401 GAGTGAAGAG ACAGCCTGTT GAATGGGAGA AAATATTTGC AAACTACTCA TCTGACAAGG TACTAATACC AGAATATACT 058480 058481 AGGAACTCCA ATAACTCAAT AGTAAACAAC AAATTAATTC CAATAAAAAG TGAGCAAAAG ACATGGATAG ATATTTCTCA 058560 058561 AAAGAAAACA TACAAGTAGC CAACAGGTAT ATTTAAAAAA AAAAGCCCAA CATCAGTAAT TATAAGGGAA ATGCAAGCCA 058640 058641 AAACCATAGT GAGAATGGCT ATTTTAAAAA GACAAAAATT AACCAATGCT GGAGAGGATG TGGAGGGAAC TCTTATACAC 058720 058721 TGTTGGTGGG AATGTAAATT AATACTATAG AAAACAGTTT GATTTCTGAA AAACCTAAAA AGAGAAATAT GACATAATCC 058800 058801 AGCAATCTCA CTACTGGATA TTTATCTAAA GGAAAAGATA TCAGTATACT AAAAATGTAC CTGCATCCCC GTGTTTATTG 058880 058881 CAGCACTATT CACAACAGCA AAGATATGGA CTCAGGAACC TAAGTGTACA TCAGTGGATA AATGGAAAAA GAAAATGAGG 058960 058961 TAAATATATA CAATGGAATA CTAATTGACC AAAGAAGAAT GAAATCATGT CCTTTGCAGC AACATGAATG GAGCTGGAGG 059040 059041 TCATTATTTT AAGCCAGGCA CAGAAAGATA ATTATCTTAT GTTATTATCA TATGTGGGAG CTATAAAAGT TGATCTCATG 059120 059121 GAGGTAGAGA GTAGAAGGAT AGATACCAAA GGCTGTGAAA GGTATGTCTG GAGGGTGAAG AGAGGTTGGT TAGTGGGTAA 059200 059201 AAATACACAG CTAGTTAGAA TAAATAATTT ATAATGTTTG ATAAGAGTTG GTTGACTATA TTTAACAATA TAATGTATAT 059280 059281 TTCAAAATAA AAAAGAGGAC TTGAAATGTT CCTAACTATA GAGATGATAA ATTGAGGGTG ATGGATACCC TGACTTGATC 059360 059361 ATTACACATT CGATGCATGT AACAATAGCA CATGTACCCC ATAAGTATTA TGTATCGGTC AAAAAAAAAA AAAAAAGGAA 059440 059441 ATCCCAGTGC TTTGGGGGGC C |
Annotation (From lncRNAdb)
| Section | Description |
|---|---|
| ID | Kcnq1ot1 |
| Name | Kcnq1ot1: Kcnq1 opposite transcript 1,LIT1: long QT intronic transcript 1 |
| Characteristics | 91 kb, unspliced; imprinted (paternally expressed), it is transcribed from intron 10 of the maternally expressed Kncq1 (KvLQT1) gene from a CpG island that is the imprinting control region (IC2) ((Smilinich 1999)). This imprinted region contains at least eight genes that are expressed exclusively or preferentially from the maternal allele ((Kanduri 2011)). |
| Expression | Nuclear localised. Expressed in most human tissues. Mouse RNA found to be highly unstable with a half-life <2 hr in N2A (neuroblastoma) cells ((Clark 2012)). |
| Function | PSummary: Kcnq1ot1 has a role in the organization of a tissue/lineage-specific nuclear domain involved in epigenetic silencing of the Kcnq1 imprinting control region. Genes imprinted by kcnq1ot1 include Kcnq1, Cdkn1c, Slc22a18 and Phlda2, which are ubiquitously imprinted and Cd81, Osbpl5, Tssc4, Tspan32 and Ascl2, which are only imprinted in placenta (reviewed in (Kanduri 2011). An expansion of the Kncq1ot1 imprinted domain to include splice variants of Th and Ins2 was recently described ((Jones 2011)). Kcnq1ot1 silences genes by coating chromatin and recruiting repressive chromatin remodeling complexes such as G9a, PRC1 and PRC2 ((Terranova 2008), (Pandey 2008), (Umlauf 2004), (Zhao 2010)) . Kcnq1ot1 transcript has a modular structure, the silencing element (that mediates the epigenetic silencing and directs the imprinted locus to a heterochromatin environment in the perinucleolar region) appears to be a short <1kb conserved sequence near the 5' of the transcript ((Mohammad 2008)). Kcnq1ot1 forms a silenced subdomain ((Terranova 2008))((Redrup 2009)) commonly localised to the perinucleolar region during S phase ((Mohammad 2008)). The silenced subdomain may be important to the maintenance of transcriptional repression. Kcnq1ot1 interacts with Dnmt1 and recruits it to somatically acquired differentially methylated regions (DMRs) of imprinted genes ((Mohammad 2010)). In vivo knockout study shows that paternal inheritance of a deletion encompassing an 890-bp (Delta890) silencing domain downstream of the Kcnq1ot1 promoter leads reduced interaction with DNMT1 and to selective incomplete relaxation of the imprinting of imprinted genes in a tissue-specific manner ((Mohammad 2010)). Delta890 showed altered DNA methylation at somatically acquired DMRs but not in histone modifications of the ubiquitously imprinted genes. Thus, it has been proposed that the ubiquitous and placental-specific imprinting of genes within the Kcnq1 domain might be mediated by distinct mechanisms, and Kcnq1ot1 RNA might mediate the silencing of ubiquitously imprinted genes by maintaining allele-specific methylation through its interactions with Dnmt1 ((Mohammad 2010)). |
| Conservation | Patches of highly conserved repeats in 5' side of transcript, which contains the silencing domain ((Mohammad 2008)). Promoter control elements are highly conserved between mouse and humans, including CCAAT elements that are targets of NF-Y regulation ((Pandey 2004)), as well as the position of CpG islands in the imprinting control region ((Paulsen 2004)). |
| Misc | (Syndromes and diseases associated, eg Beckwith-Wiedemann syndrom, and cancers (see references list): Associated with multiple balanced chromosomal rearrangements in Beckwith-Wiedemann syndrome (BWS) and an additional break-point in embryonal rhabdoid tumours; in particular, aberrant methylation of the CpG island associated with Kcnq1ot1 promoter is strongly associated with cancer risk and specific birth defects in BWS ((Smilinich 1999))). For review on Kcnq1ot1 mechanism of action see ((Kanduri 2011)). |
