Difference between revisions of "GCASPC"
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==Annotated Information== | ==Annotated Information== | ||
| + | [[File:GCASPC decreases the protein level and activity of PC by inhibiting its protein stability.jpg|right|thumb|400px|'''GCASPC decreases the protein level and activity of PC by inhibiting its protein stability'''<ref name="ref1" />]] | ||
| + | [[File:GCASPC is a target of miR-17-3p.jpg|right|thumb|400px|'''GCASPC is a target of miR-17-3p'''<ref name="ref1" />]] | ||
===Approved Symbol=== | ===Approved Symbol=== | ||
GCASPC | GCASPC | ||
===Approved Name=== | ===Approved Name=== | ||
gall bladder cancer associated suppressor of pyruvate carboxylase lncRNA | gall bladder cancer associated suppressor of pyruvate carboxylase lncRNA | ||
| − | |||
| − | |||
===Synonyms=== | ===Synonyms=== | ||
"TCONS_00011605, RP1-56L9.7-001, lnc-SOD2-1" | "TCONS_00011605, RP1-56L9.7-001, lnc-SOD2-1" | ||
===Chromosome=== | ===Chromosome=== | ||
6q25.3 | 6q25.3 | ||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
===Disease=== | ===Disease=== | ||
gallbladder cancer | gallbladder cancer | ||
| + | ===Characteristics=== | ||
| + | GCASPC is a long noncoding RNA and it is located within the intron of insulin-like growth factor 2 receptor (IGF2R).<ref name="ref1" /> | ||
| + | Subcellular fractionation analysis reveals GCASPC is mainly located in the cytoplasm of gallbladder cancer cells.<ref name="ref1" /> | ||
| + | ===Expression=== | ||
| + | Compared with the non tumor tissues, GCASPC is down-regulated in gallbladder cancer tissues.<ref name="ref1" /> | ||
| + | ===Function=== | ||
| + | Gain and loss of function studies in gallbladder cancer cells shows that GCASPC can suppresses gallbladder cancer cell proliferation.<ref name="ref1" /> | ||
| + | GCASPC decreases the protein level and activity of PC by inhibiting its protein stability.<ref name="ref1" /> | ||
| + | ===Regulation=== | ||
| + | GCASPC can be directly targeted by miR-17-3p.<ref name="ref1" /> | ||
| + | ==Labs working on this lncRNA== | ||
| + | * Department of General Surgery, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Institute of Biliary Tract Disease, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Department of Gastric Cancer and Soft Tissue Sarcoma, Fudan University Shanghai Cancer Center, Shanghai, China. | ||
| + | ==References== | ||
| + | <references> | ||
| + | <ref name="ref1"> Ma, M.Z., et al., Long Noncoding RNA GCASPC, a Target of miR-17-3p, Negatively Regulates Pyruvate Carboxylase-Dependent Cell Proliferation in Gallbladder Cancer. Cancer Res, 2016. 76(18): p. 5361-71. | ||
| + | </ref>(1) | ||
| + | </references> | ||
Latest revision as of 15:35, 22 October 2017
Contents
Annotated Information
GCASPC decreases the protein level and activity of PC by inhibiting its protein stability[1]
GCASPC is a target of miR-17-3p[1]
Approved Symbol
GCASPC
Approved Name
gall bladder cancer associated suppressor of pyruvate carboxylase lncRNA
Synonyms
"TCONS_00011605, RP1-56L9.7-001, lnc-SOD2-1"
Chromosome
6q25.3
Disease
gallbladder cancer
Characteristics
GCASPC is a long noncoding RNA and it is located within the intron of insulin-like growth factor 2 receptor (IGF2R).[1] Subcellular fractionation analysis reveals GCASPC is mainly located in the cytoplasm of gallbladder cancer cells.[1]
Expression
Compared with the non tumor tissues, GCASPC is down-regulated in gallbladder cancer tissues.[1]
Function
Gain and loss of function studies in gallbladder cancer cells shows that GCASPC can suppresses gallbladder cancer cell proliferation.[1] GCASPC decreases the protein level and activity of PC by inhibiting its protein stability.[1]
Regulation
GCASPC can be directly targeted by miR-17-3p.[1]
Labs working on this lncRNA
- Department of General Surgery, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Institute of Biliary Tract Disease, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Department of Gastric Cancer and Soft Tissue Sarcoma, Fudan University Shanghai Cancer Center, Shanghai, China.
