Difference between revisions of "LINC01567"

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<ref name="ref1"> Yu X, Mi L, Dong J, Zou J. Long intergenic non-protein-coding RNA 1567 (LINC01567) acts as a “sponge” against microRNA-93 in regulating the proliferation and tumorigenesis of human colon cancer stem cells. BMC cancer. 2017, 17(1):716. </ref>(1)
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Revision as of 05:47, 18 December 2018

LINC01567, is a long non-coding RNA with the ability to competitively inhibit miRNA, and acts as molecular “sponge”.

Annotated Information

Name

LINC01567: long intergenic non-protein coding RNA 1567 9HGNC nomenclature). Synonym: LOCCS [1].

Characteristics

LINC01567 gene is located on chromosome 16 (positions 24,661,422–24,671,062 on the reverse strand), contains three exons and produces one transcript (2907 bp) [1].

Function

LINC01567 or LOCCS, has an upregulated expression in colon cancer stem cells. Knockdown of LOCCS reduces cell proliferation, invasion, migration, and generation of tumor xenografts [1]. Also, microRNA-93 (miR-93) and Musashi-1 mediated the tumor suppression of LOCCS knockdown [1]. Reciprocal repression has been observed between LOCCS and miR-93. A predicted miR-93 binding site is identified in LOCCS. This provides important roles of the lncRNA–microRNA functional network in human colon cancer [1].

Regulation

NA

Diseases

  • Colorectal carcinoma (CC) [1]

Expression

LINC01567 is highly upregulated in in colon cancer stem cells [1].

Experiment Forward primer Reverse primer
qRT-PCR 5'-TGCTGGGGAAAGGAGATTGG- 3' 5'-AGCAGAAGTAAGGCACGAGG- 3'[1]

Labs working on this lncRNA

  • Department of Gastroenterology, Huadong Hospital Affiliated to Fudan University, West Yan’an Road 221, Shanghai, 200040 China. [1]
  • Drug Clinical Trial Organization Office, Huadong Hospital Affiliated to Fudan University, Shanghai, 200040 China. [1]

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 Yu X, Mi L, Dong J, Zou J. Long intergenic non-protein-coding RNA 1567 (LINC01567) acts as a “sponge” against microRNA-93 in regulating the proliferation and tumorigenesis of human colon cancer stem cells. BMC cancer. 2017, 17(1):716.

Sequence

>gi|400511|ref|NR_122072.1| Homo sapiens long intergenic non-protein coding RNA 1567 (LINC01567), long non-coding RNA

000001 AGTGCTGTCG GAGGGTTGCT GGGGAAAGGA GATTGGCTGG CGAGGAAGAT GAGGAATGTG CTGCCAGGAG ACTGGGATCA 000080
000081 CGGCCAGATG CTAATTACGA TGGCCTGGGG GTGCTGGTAC CCCCTGTCAG CATCATATCA GCCTCTCCAC TTCAAATCCT 000160
000161 GCCCCTCTGA TGTTAGAATC TGGCTGCAAC CATCCCGTGA TTCTGTGGAG CCTCGTGCCT TACTTCTGCT GGCTTCTGTC 000240
000241 TGTCGTCACT TCCGTTCTCC ACCACCCTGG CCTCAATCAA ACACGTTTTC TCTGATGCAA AACTCGACCT TCATTTACAG 000320
000321 AAAGGGTTAT CTCAAGAGGC TTGGGATGGT TAAACCCTGC ACATCTCAGA GGAAGGACTG GCTCTTCACC TGTTCCTGCA 000400
000401 GGATAACTGC TAACGGCTTA AAATATTCTG CCTGATAAGA GGGCTTCTGT ATATCTGGGG CCTTGGGCCA TGCCGGGTAG 000480
000481 TTGATGCTAA CAACATGATT TATGGTGGGT GCCTGCGGTC ATGCTGTATC AGCCTGACCT CTGGAGGGGC TGGACACTGG 000560
000561 GTAACTGATC CCCAAGAAAA GCCATGGACA CTAAGGCTCA GGTGAGTTCC CCTGGTTGGC AGTGTTTTGC GTGTGTTGTC 000640
000641 ACACATCATT GCTGGGAGAC TTAAGCACTG CACATATGAC TATCTAGGAG GGTACAGCTG CAAGCTCCTG CCTGGATTCT 000720
000721 GCCCTGAGCA CCTTTTTCCT TTGCTGATTT TGTTTATCTA TTTATTTATT TTTGAGATGG AGTCTCACTC TGTCACCAAG 000800
000801 GTTGGAGTGC GGTGGCTGGA TCTCGGCTCA TTGCAACCTC CACCTCCCAG GTTCACGTGA TTCTTCTGCT TCAGCCTCCC 000880
000881 AAGGAGCTGG GATTACAGGT GCCAACCACC ATGCCTGGCT AATTCTTATA TGTTAGTAGA GACGGGGTTT TGCCATGTTG 000960
000961 GCCAGGCTGG TCTCGAACTC CTGAGCTCAA GTGACAAGGC CGCCGGCCTC GACCTCCCAA AGTGCTGGGA TTACAGGCAT 001040
001041 GAGCCACCGC GCCTGGCCCC TTTGCTGATT TTTAATCCGC ATCCTTCCAC TGTGTTAAGC TGTAACTGTG AATACAACAG 001120
001121 CTTTTTTGAG TTCTGCGATT CTTTGCAGCA AATCGTCATA CCTGAGCGTG TCTTGGGGAC TCCCCGACAC ATCTTCCCAC 001200
001201 TCCCTCTTCT GTTTTCTCAC TTCCTCTGGA GTAAACTGAA AGAGGCCCCT GCTTGCCTCT TGCAAGGCAG TTCTGAACAC 001280
001281 ACTGAGATCA TTTGTGATCT CATATCCTCT TCTAAGCAAT TCATCAAGAA ATTTCTTTCA AATAAACCCA GTGCTCTTCA 001360
001361 TGGAGGTGAT GCTGATGAAA ATGACTTTCT CCAGCTTATT ACACGTTTGC AGAAGCTCCT GTTTAAGAGT TTGAGCATGT 001440
001441 ATGTGTGTGT GCATATACAC CAGCACACAC ATGCATGCCC ACAGCTGTCA TGCCTTCACC AGAACCAGGA CGAGGAGTTA 001520
001521 TTCTATTGCC AGAATTGAAG AACCATTTCC ACATATTGTA AGGTCAGTGA AAGTACAATG AAAAATACAC CTGCTAGCAT 001600
001601 GCCTATGCAT GGCCTCTCTG CAAATAAGAT GAAGGTCCCT TCACCACCTG CTTGCACTGC TAATGGCCCT GTAGATTCCA 001680
001681 CTGGATGGAT TTGTAATTTT CTCAACCATT TCCCCTAATG CTGGATATTT GGGTTATTTC CAACATTTTT ACGCTTCCAA 001760
001761 ATAAGGCACC CATAATGATT CTTGCAGAGT AATCATTAGG CTCTTCTATA ATTATCTAAT TATCCTTTTT TTTTTGTTTT 001840
001841 TTTCTGAGGC AGGGTCTTGC TCTGACACCC AGGCTGGAGT ACAGCGGCAC GATCATGGCT CACTGCAGCC TCAGCCTCCC 001920
001921 ACGCTCAAGT GATTCCACAG TCTCAGCCTC CTGTGTAGCT GGGATCACAG GTGTGCGCCA CCACGCCTGG CTAACTTTTT 002000
002001 GTACTTTTTA TAGAGACGGG GAGTTTTTTT GTATTTTTTT AAATAGAGAC GATGTCTCAC CATGTTGCTT AG